Inhibitory Effect of an Extract of Leaves of Rosmarinus Officinalis L. On Tumor Initiation and Promotion in the Skin of Cd-1 Mice

Huang, Mou Tuan; Ct, Ho; Wang, Z.Y.; Stauber, Kathe; Georgiadis, Constantino; Laskin, Jeffrey D.; Conney, Allan H.

doi:10.1533/9781845698256.4.209

Cited by 14 publications

(13 citation statements)

References 7 publications

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“…In addition, ursolic acid has showed a broad spectrum of activities to influence cancer progression and development, including interfering tumorigenesis, metastasis and angiogenesis, and inducing tumor cell apoptosis and differentiation [3][4][5]. Studies using in vivo animal models have confirmed the chemo-preventive ability of ursolic acid [6][7][8][9]. Further, ursolic acid inhibits experimental metastasis of esophageal carcinoma [5,10].…”

Section: Introductionmentioning

confidence: 99%

Ursolic acid induces ER stress response to activate ASK1–JNK signaling and induce apoptosis in human bladder cancer T24 cells

Zheng

Jin

et al. 2013

Cellular Signalling

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Section: Introductionmentioning

confidence: 99%

Ursolic acid induces ER stress response to activate ASK1–JNK signaling and induce apoptosis in human bladder cancer T24 cells

Zheng

Jin

et al. 2013

Cellular Signalling

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“…OA is ascertained to have anti-diabetogenic [3] and hepatoprotective activities [4]. UA is used as a significant antitumorigenesis [5][6] and antioxidant [7] agent.…”

Section: Introductionmentioning

confidence: 99%

A comparative study of the separation of oleanolic acid and ursolic acid in Prunella vulgaris by high-performance liquid chromatography and cyclodextrin-modified micellar electrokinetic chromatography

Du¹,

Chen

2009

JICS

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A high-performance liquid chromatographic (HPLC) method and a cyclodextrin-modified micellar electrokinetic chromatographic (CD-MEKC) method were developed to separate and determine oleanolic acid (OA) and ursolic acid (UA) in Prunella vulgaris. HPLC separations were carried out on a Hedera ODS C 18 column with methanol -H 2 O-acetic acid (85:15:0.3, v/v/v) as mobile phase at a flow-rate of 0.8 ml min -1 . CD-MEKC analysis was performed on a CL1030 capillary electrophoresis system with a 6% (v/v) methanol solution (pH = 9.0) containing 10 mM disodium tetraborate, 10 mM sodium dihydrogen phosphate, 50 mM sodium dodecylsulfate (SDS), 15 mM 2-hydroxypropyl-ȕ-cyclodextrin (2-HP-ȕ-CD) as background electrolyte. The analytical results of HPLC and CD-MEKC were compared with each other. CD-MEKC has better analytical efficiency for two components, and the analytical time (15 min) was shorter than that of HPLC (35 min).

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“…1) in a murine two-stage skin carcinogenesis experiment 30–32 , the same mouse model was used to explore the efficacy of four pentacyclic triterpene natural products with ursolic acid-like structure and oxidative pattern: maslinic acid 5 , 3- epi -maslinic acid 6 , corosolic acid 7 , and 3- epi -corosolic acid 8 (Fig. 2).…”

mentioning

confidence: 99%

Synthesis of oxygenated oleanolic and ursolic acid derivatives with anti-inflammatory properties

Nelson

Camelio

Claussen

et al. 2015

Bioorganic & Medicinal Chemistry Letters

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The scalable syntheses of four oxygenated triterpenes have been implemented to access substantial quantities of maslinic acid, 3-epi-maslinic acid, corosolic acid, and 3-epi-corosolic acid. Semi-syntheses proceed starting from the natural products oleanolic acid and ursolic acid. Proceeding over five steps, each of the four compounds can be synthesized ongram scale. Divergent diastereoselective reductions of α-hydroxy ketones provided access to the four targeted diol containing compounds from two precursors of the oleanane or ursane lineage. These compounds were subsequently evaluated for their ability to inhibit inflammatory gene expression in a mouse model of chemically induced skin inflammation. All compounds possessed the ability to inhibit the expression of one or more inflammatory genes induced by 12-O-tetradecanoylphorbol-13 acetate in mouse skin, however, three of the compounds, corosolic acid, 3-epi-corosolic acid and maslinic acid were more effective than the others. The availability of gram quantities will allow further testing of these compounds for potential anti-inflammatory activities as well as cancer chemopreventive activity.

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Inhibitory Effect of an Extract of Leaves of Rosmarinus Officinalis L. On Tumor Initiation and Promotion in the Skin of Cd-1 Mice

Cited by 14 publications

References 7 publications

Ursolic acid induces ER stress response to activate ASK1–JNK signaling and induce apoptosis in human bladder cancer T24 cells

Ursolic acid induces ER stress response to activate ASK1–JNK signaling and induce apoptosis in human bladder cancer T24 cells

A comparative study of the separation of oleanolic acid and ursolic acid in Prunella vulgaris by high-performance liquid chromatography and cyclodextrin-modified micellar electrokinetic chromatography

Synthesis of oxygenated oleanolic and ursolic acid derivatives with anti-inflammatory properties

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