Inhibitory Effect of Chitosan-Containing Lotion on Scratching Response of Hairless Mice with Atopic Dermatitis-Like Dry Skin

Fujii, Masanori; Shimizu, Tatsuo; Nakamura, Takeshi; Endo, Fumio; Kohno, Shigekatsu; Nabe, Takeshi

doi:10.1248/bpb.34.1890

Cited by 9 publications

(7 citation statements)

References 17 publications

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“…We previously treated distal radius fractures in limbs containing shunts in dialysis patients with skin fragility using volar locking plate as well as this case [ 9 ]. In patients with skin fragility, conservative treatment by splinting or casting is difficult [ 10 , 11 ]. In addition, percutaneous pinning or external fixation may increase aggravation of skin lesions and infection [ 12 ].…”

Section: Discussionmentioning

confidence: 99%

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Minimally Invasive Plate Osteosynthesis for a Distal Radius Fracture with Forearm Skin Problem

Naïto

Sugiyama

Kinoshita

et al. 2018

Case Reports in Orthopedics

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In this study, we performed osteosynthesis for a distal radius fracture using a minimally invasive approach for a patient with skin disorder of the forearm and obtained favorable results. This case report may provide new findings confirming the usefulness of this surgical approach for distal radius fractures. Blister formation on the right forearm was observed in a 53-year-old female who was diagnosed with a distal fracture of the right radius and underwent splinting in a local hospital, and she was referred to our hospital 2 days after the injury. Minimally invasive locking plate osteosynthesis was performed, and there was no skin lesion at this incision site. Postoperatively, there were no complications in soft tissues and the operative scar was almost unrecognizable. We reported volar locking plate osteosynthesis using the minimally invasive approach in a patient with skin disorder of the forearm. Such patients are rarely encountered. However, this minimally invasive approach is extremely useful for utilizing the advantages of volar locking plate fixation without being affected by the soft tissue environment.

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Section: Discussionmentioning

confidence: 99%

“…We speculated about the development of the skin disorder in this patient. Some patients with skin disorders due to splinting and casting have been reported [ 10 , 13 ]. Blister formation and burns at moderate temperatures are widely known and have recently been applied to the production of animal models of burn injury [ 14 ].…”

Section: Discussionmentioning

confidence: 99%

Minimally Invasive Plate Osteosynthesis for a Distal Radius Fracture with Forearm Skin Problem

Naïto

Sugiyama

Kinoshita

et al. 2018

Case Reports in Orthopedics

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“…The application of chitosan strongly inhibited itch-related scratching in hairless mice associated with barrier-disrupted dry skin. 48 The inhibitory mechanism could be explained by recovery of skin barrier function.…”

Section: Reduction Of Erythema Induced By Nicotinatesmentioning

confidence: 99%

Development of an Amphiphilic Chitin Derivative with Lipid/Peptide-Type Side Chains Having Skin Protective Ability

Aoi¹

2015

JNHFE

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“…However, the mechanism of itch has not been fully discovered, but lots of elements including genetic, environmental and immune factors are the dangerous elements of pruritus [6]. In particular, dry skin, which is associated with incomplete cuticle and disrupted epidermal barrier, could be one of the triggering factors of pruritus [7]. Thus, the method of alleviating skin dryness and rebuilding the skin barrier is thought to be an important therapeutic treatment for pruritus.…”

Section: Introductionmentioning

confidence: 99%

Effects of Silk Fibroin Moisturizing Cream on Acetone/Ether-Induced Dry Skin Pruritus in Mice

He¹,

Tong²

2019

JCDSA

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Objectives: The morbidity of dry and itchy skin was high during a person's lifetime and it had a significant negative impact. This study aimed to investigate the positive effect of silk fibroin moisturizing cream on dry skin pruritus induced by acetone/ether-water (AEW) method in mice. Method: We established a dry skin model in mice with AEW treatment, and the control group was treated with ultrapure water. The mice in AEW model group were locally administrated with silk fibroin moisturizing cream (SilkArmor) ®. The transepidermal water loss (TEWL), scratching behavior, condition of skin erythema, skin histology (by hematoxylin-eosin staining) and the results of electron microscopy were measured to evaluate the positive effect of SilkArmor on dry and itchy skin in mice. Results: The TEWL value, spontaneous scratching behavior and erythema score were significantly increased after AEW modeling compared with the control group. There was no significant difference in the TEWL value, scratching behavior and erythema score between the Sil-kArmor group and the control group (P > 0.05). Compared with the AEW group, the value of TEWL, scratching behavior and the erythema score of mice in the AEW + SilkArmor group were improved, with statistically significant differences (P < 0.05). Skin histopathology and electron microscopy also showed that SilkArmor had certain improvement and repairment on AEW-induced skin pathological changes. Conclusions: A dry skin model was successfully established in this experiment, showing that SilkArmor brought an obvious alleviation to AEW-induced dry and itchy skin in mice.

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Inhibitory Effect of Chitosan-Containing Lotion on Scratching Response of Hairless Mice with Atopic Dermatitis-Like Dry Skin

Cited by 9 publications

References 17 publications

Minimally Invasive Plate Osteosynthesis for a Distal Radius Fracture with Forearm Skin Problem

Minimally Invasive Plate Osteosynthesis for a Distal Radius Fracture with Forearm Skin Problem

Development of an Amphiphilic Chitin Derivative with Lipid/Peptide-Type Side Chains Having Skin Protective Ability

Effects of Silk Fibroin Moisturizing Cream on Acetone/Ether-Induced Dry Skin Pruritus in Mice

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