Inhibitory Effect of Chitosan Oligosaccharide on Human Hepatoma Cells in Vitro

Liu, Likun; Xin, Yi; Liu, Jia; Zhang, Ershao; Li, Weiling

doi:10.21010/ajtcam.v14i4.30

Cited by 18 publications

(6 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Many in vitro studies conducted so far have also revealed the inhibitory effect of this biopolymer on a significant reduction in cancer cell growth and tumor mass. An example is the inhibition of the growth of human hepatoma cells (HepG2) by increasing the expression of the caspase-3 protein, which thus induced cell apoptosis [ 180 ]. Treatment of human colon cancer cells (HT-29) with a low dose of chitosan resulted in an increase in the production of some antioxidant enzymes, including glutathione, glutathione S-transferase and quinine reductase, indicating the antitransformative and chemopreventive effects of chitosan [ 181 ].…”

Section: Applicationsmentioning

confidence: 99%

“…In the initial phase, the polymer inhibits COX-2 expression and NF-kB also inhibits inflammation, while increasing the level of the antioxidant enzyme, and AMPK activity prevents the transformation of normal cells into abnormal cells [ 182 ]. As the tumor develops, chitosan reduces tumor mass growth by inhibiting the expression of proteins related to cellular metabolism, including mTOR, catenin B, pyruvate kinase, and ornithine decarboxylase, as well as activation of the caspase-3 and IL-12 pathways, inducing cell apoptosis [ 180 ].…”

Section: Applicationsmentioning

confidence: 99%

See 1 more Smart Citation

Chitin and Chitosan as Polymers of the Future—Obtaining, Modification, Life Cycle Assessment and Main Directions of Application

et al. 2023

View full text Add to dashboard Cite

Natural polymers are very widespread in the world, which is why it is so important to know about the possibilities of their use. Chitin is the second most abundant reproducible natural polymer in nature; however, it is insoluble in water and basic solvents. Chitin is an unused waste of the food industry, for which there are possibilities of secondary management. The research led to obtaining a soluble, environmentally friendly form of chitin, which has found potential applications in the many fields, e.g., medicine, cosmetics, food and textile industries, agriculture, etc. The deacetylated form of chitin, which is chitosan, has a number of beneficial properties and wide possibilities of modification. Modification possibilities mean that we can obtain chitosan with the desired functional properties, facilitating, for example, the processing of this polymer and expanding the possibilities of its application, also as biomimetic materials. The review contains a rich description of the possibilities of modifying chitin and chitosan and the main directions of their application, and life cycle assessment (LCA)—from the source of the polymer through production materials to various applications with the reduction of waste.

show abstract

Section: Applicationsmentioning

confidence: 99%

Section: Applicationsmentioning

confidence: 99%

Chitin and Chitosan as Polymers of the Future—Obtaining, Modification, Life Cycle Assessment and Main Directions of Application

et al. 2023

View full text Add to dashboard Cite

show abstract

“…Chitosan nanoparticles have a wide range of promising applications in anti-tumor effects, including hepatocellular carcinoma, gastric cancer, colorectal cancer, and lung cancer [ 5 , 41 ]. As indicated in Figure 5 , chitosan has anti-proliferative activity against tumor cells, and Liu et al showed that chitosan induced apoptosis in tumor cells by decreasing Bcl-2 and increasing Caspase-3 expression [ 42 , 43 ] ( Figure 5 A). Carboxymethyl chitosan (CM-COS) enhances macrophage viability, infiltrates heavily into the tumor microenvironment, produces cytokines such as TNF-α and IL-1, enhances phagocytosis and upregulates NO levels.…”

Section: Chitosan In Biomedical Applicationsmentioning

confidence: 99%

Application of Chitosan and Its Derivative Polymers in Clinical Medicine and Agriculture

Zhang

et al. 2022

Polymers

View full text Add to dashboard Cite

Chitosan is a biodegradable natural polymer derived from the exoskeleton of crustaceans. Because of its biocompatibility and non-biotoxicity, chitosan is widely used in the fields of medicine and agriculture. With the latest technology and technological progress, different active functional groups can be connected by modification, surface modification, or other configurations with various physical, chemical, and biological properties. These changes can significantly expand the application range and efficacy of chitosan polymers. This paper reviews the different uses of chitosan, such as catheter bridging to repair nerve broken ends, making wound auxiliaries, as tissue engineering repair materials for bone or cartilage, or as carriers for a variety of drugs to expand the volume or slow-release and even show potential in the fight against COVID-19. In addition, it is also discussed that chitosan in agriculture can improve the growth of crops and can be used as an antioxidant coating because its natural antibacterial properties are used alone or in conjunction with a variety of endophytic bacteria and metal ions. Generally speaking, chitosan is a kind of polymer material with excellent development prospects in medicine and agriculture.

show abstract

“…The modification of encapsulated curcumin micellar nanoparticles with a biodegradable polymer enhances curcumin's solubility, stability, Bcl-2 (Liu, Xin, Liu, Zhang, & Li, 2017). Such properties of chitosan have fascinated researchers for making a chitosan polymeric nanoparticle drug transport system (Geetha, Sivaram, Jayakumar, & Gopi Mohan, 2016) and proved that the system had a good drug capture capability and increased curcumin cytotoxicity for GC cells.…”

Section: Enhancing the Efficacy Of Curcumin By Loaded Drug Delivery S...mentioning

confidence: 99%

“…The amine group is protonated in acidic pH, the system disintegrates into individual polymer chains and then the drug is released. Moreover, chitosan has its own anticancer activity, for example, stimulation of caspase‐2 and caspase‐3 and inhibition of Bcl‐2 (Liu, Xin, Liu, Zhang, & Li, 2017). Such properties of chitosan have fascinated researchers for making a chitosan polymeric nanoparticle drug transport system (Geetha, Sivaram, Jayakumar, & Gopi Mohan, 2016) and proved that the system had a good drug capture capability and increased curcumin cytotoxicity for GC cells.…”

Section: Strategy For Improving Therapeutic Potential Of Curcuminmentioning

confidence: 99%

Pleiotropic nature of curcumin in targeting multiple apoptotic‐mediated factors and related strategies to treat gastric cancer: A review

Shetty

Prabhakaran

Srivastava

2021

Phytotherapy Research

View full text Add to dashboard Cite

Gastric cancer (GC) is one of the major reasons for cancer-associated death and exhibits the second-highest mortality rate worldwide. Several advanced approaches have been designed to treat GC; however, these strategies possess many innate complications. In view of this, the upcoming research relying on natural products could result in designing potential anticancer agents with fewer side effects. Curcumin, isolated from the rhizomes of Curcuma longa L. has several medicinal properties like antiinflammatory, antioxidant, antiapoptotic, antitumor, and antimetastatic. Such pleiotropic nature of curcumin impedes the invasion and proliferation of GC by targeting several oncogenic factors like p23, human epidermal factor receptor2 including Helicobacter pylori. The side effect of chemotherapy, that is, chemotherapeutic resistance and radiotherapy could be reduced combination therapy of curcumin. Moreover, the photodynamic therapy of curcumin destroys the cancer cells without affecting normal cells. However, further more potential studies are required to establish the potent efficacy of curcumin in the treatment of GC. The current review details the anticancer activities of curcumin and related strategies which could be employed to treat GC with additional focus on its inhibitory properties against viability, proliferation, and migration of GC cells through cell cycle arrest and stimulation by apoptosis-mediated factors.

show abstract

Inhibitory Effect of Chitosan Oligosaccharide on Human Hepatoma Cells in Vitro

Abstract: Background: Chitosan oligosaccharide, the degradation products of chitin, was reported to have a wide range of

Cited by 18 publications

References 15 publications

Chitin and Chitosan as Polymers of the Future—Obtaining, Modification, Life Cycle Assessment and Main Directions of Application

Chitin and Chitosan as Polymers of the Future—Obtaining, Modification, Life Cycle Assessment and Main Directions of Application

Application of Chitosan and Its Derivative Polymers in Clinical Medicine and Agriculture

Pleiotropic nature of curcumin in targeting multiple apoptotic‐mediated factors and related strategies to treat gastric cancer: A review

Contact Info

Product

Resources

About