Inhibitory Effect of Curcumin on Early Liver Regeneration Following Partial Hepatectomy in Rats

Seehofer, Daniel; Schirmeier, Anja; Bengmark, S; Carter, Jessica; Koch, Martin; Glanemann, Matthias; Nüssler, Andreas K.; Neuhaus, P.; Menger, Michael D.

doi:10.1016/j.jss.2008.09.011

Cited by 14 publications

(14 citation statements)

References 21 publications

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“…In our experimental conditions of microsurgical cholestasis, the expression of both the p65 subunit of NF-κB and iNOS increased significantly. However, according to Seehofer et al, 43 the total liver mass and function might not be significantly altered, which corresponds well with our results. This process was assumed to involve the transcriptional induction of various apoptotic suppressors.…”

Section: Discussionsupporting

confidence: 94%

“…38 As NF-κB upregulates iNOS, which is another inflammatory marker, we decided to determine the expression of both the p65 subunit of NF-κB and iNOS in the liver. 43 These processes could be associated with liver fibrosis. Numerous studies, however, have shown that NF-κB provides survival signals in the context of death receptor-induced apoptosis in the liver.…”

Section: Discussionmentioning

confidence: 99%

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The effect of curcumin on liver fibrosis in the rat model of microsurgical cholestasis

et al. 2015

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We aimed to determine the effects of curcumin on liver fibrosis and to clarify the role of nuclear factor-κB (NF-κB) and inducible nitric oxide synthase (iNOS) in a model of microsurgical cholestasis in the early stage of extrahepatic biliary atresia. Twelve-week-old Wistar rats were divided into four groups (n = 8): sham-operated rats (received olive oil after laparotomy); a curcumin group (received curcumin, 200 mg kg(-1) per day, after laparotomy); a biliary duct ligated group (BDL, received olive oil after operation); and a biliary duct ligated/curcumin group (BDL curc, received curcumin, 200 mg kg(-1) per day, after operation). After 3 weeks of treatment, curcumin did not modify blood plasma markers as well as the expressions of iNOS and NF-κB (p65) in the livers of the sham group. Interestingly, there was a significant increase in the extent of both liver and kidney fibrosis. On the other hand, despite a decrease in the expression of iNOS and NF-κB (p65), treatment with curcumin did not affect fibrosis enlargement due to bile duct ligation in the liver. In the BDL group, treatment with curcumin decreased the level of blood plasma markers investigated. In conclusion, treatment with curcumin was able to improve the functional properties of hepatocytes and to inhibit the upregulations of both NF-κB and iNOS in the BDL group; however, no beneficial effect was observed on the liver fibrosis developed in this model of cholestasis. Thus, in the studied model of microsurgical cholestasis, other factors different from NF-κB and iNOS are responsible for fibrotic processes in the liver.

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Section: Discussionsupporting

confidence: 94%

Section: Discussionmentioning

confidence: 99%

The effect of curcumin on liver fibrosis in the rat model of microsurgical cholestasis

et al. 2015

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“…Our group has shown in coeval experiments that even normal liver regeneration after 70% partial hepatectomy in rats is inhibited by application of curcumin, mainly at the level of the G2/M transition point [25]. This might also contribute towards the unchanged depression of liver regeneration despite improvements of the inflammatory response and oxidative stress.…”

Section: Discussionmentioning

confidence: 93%

Curcumin Attenuates Oxidative Stress and Inflammatory Response in the Early Phase after Partial Hepatectomy with Simultaneous Intraabdominal Infection in Rats

Seehofer

Schirmeier

Bengmark³

et al. 2010

Journal of Surgical Research

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“…It should be emphasized that before and after PH, increased mitotic cell activity (especially in groups 3-5) were supported by silymarin application and/or SDOA consumption (p<0.05), (Tables 2 and 3). It was reported by Kirimlioglu et al [35] and Seehofer et al [40] that PH increases mitotic cell activity of the liver and Akcan et al [41] noted that mitotic cells can be detected frequently at 24 and 48 h after PH, increasing especially at 24 and 36 h and decreasing to lower levels at 96 h of PH. In addition, silymarin administration similar histopathological findings as ameliorative effects were reported by El-Adawi et al [9].…”

Section: Comparing the Regenerative Effects Of Silymarin And Apricot mentioning

confidence: 92%

Comparing the regenerative effects of silymarin and apricot on liver regeneration after partial hepatectomy in rats

Yılmaz¹,

Hatipoğlu²,

Taşlıdere³

et al. 2018

biomedicalresearch

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This study is aimed to investigate and compare the regenerative effects of Silymarin (SLM); and Sun Dried Organic Apricot (SDOA) on liver regeneration after 70% Partial Hepatectomy (PH) in rats. Rats mean weighing was 238.1 ± 17.8 g, and they were randomly divided into the five groups. During the 17 d of the study period, the following feed and drug administration order was maintained: group 1 (sham) (n=6) and group 2 (n=8) were fed with standard rat chow, group 3 (n=8) was fed with standard rat chow and given additionally daily 100 mg/kg dose of silymarin extract by gavage, group 4 (n=8) was fed with 10% supplemented SDOA to chow and, in addition, they were given daily 100 mg/kg dose silymarin extract by gavage, and group 5 (n=8) was fed with 10% supplemented SDOA to chow. Water was given ad-libitum to all groups. After a week, group 1 had a laparoscopic procedure; the others underwent a 70% PH. On 18 th d of the study, all rats were humanely sacrificed. Taken liver tissue samples of all groups were used to histopathological and tissue biochemical examination. Approximately 10 ml blood samples were taken and the obtained serum samples were used for measurement of serum Aspartate Transaminase (AST) AST, Alanine Transaminase (ALT) and Alkaline Phosphatase (ALP) levels. The results of the present study revealed a remarkable protective effect of silymarin rather than SDOA based on the histopathological and Proliferating Cell Nuclear Antigen, (PCNA). PCNA findings and liver tissue/serum biochemical parameters. Therefore, before 7 and after 10 d of PH, silymarin administration have shown beneficial effect than SDOA consumption on liver regeneration of rats.

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Inhibitory Effect of Curcumin on Early Liver Regeneration Following Partial Hepatectomy in Rats

Cited by 14 publications

References 21 publications

The effect of curcumin on liver fibrosis in the rat model of microsurgical cholestasis

The effect of curcumin on liver fibrosis in the rat model of microsurgical cholestasis

Curcumin Attenuates Oxidative Stress and Inflammatory Response in the Early Phase after Partial Hepatectomy with Simultaneous Intraabdominal Infection in Rats

Comparing the regenerative effects of silymarin and apricot on liver regeneration after partial hepatectomy in rats

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