Inhibitory effect of d-allose on neutrophil activation after rat renal ischemia/reperfusion

D-Ribose Attenuates Ischemia/Reperfusion-Induced Renal Injury by Reducing Neutrophil Activation in Rats

“…5620960;. We also found that D-allose reduces I/R-induced renal injury by inhibiting neutrophil activation in rats (Ueki et al 2007). Since these results suggest that monosaccharides may have inhibitory action of activation of neutrophil, we screened some of monosaccharides, which have inhibitory action of activation of neutrophils.…”

“…Recently, several groups have focused their attention on the biological functions of monosaccharides in medicine (Hossain et al 2003;Ueki et al 2007). The monosaccharide D-allose was reported to inhibit segmented neutrophil production and lower platelet counts in vivo, without any other significant detrimental effects in rats (Arnold et al US patent no.…”

Protective Action of D-Ribose against Renal Injury Caused by Ischemia and Reperfusion in Rats with Transient Hyperglycemia

“…The biological effects of rare sugars such as D-allose have recently been investigated in detail (Hossain et al 2003;Hirooka et al 2006). We also reported that D-allose attenuates renal I/R-induced injury by suppressing neutrophil activation in normoglycemic rats (Ueki et al 2007). However, the use of these rare sugars for humans remains limited, since the biological function and bioavailability of rare sugars is still poorly understood.…”

“…Many clinical studies have documented the adverse effects of chronic hyperglycemia on patient outcomes (McCowen et al 2001). In this connection, intensive insulin therapy to maintain blood glucose <110 mg/dl has recently been reported to prevent acute renal failure and reduce morbidity and mortality among critically ill patients in a surgical intensive care unit (van den Berghe et al 2001). Furthermore, hyperglycemia is most probably a contributing factor in the development of ischemic acute renal failure in critically ill patients.…”

“…Rare sugars are defined as monosaccharides that exist in nature but are present only in limited quantities. We have reported that rare sugar D-allose attenuates renal I/R-induced injury by suppressing neutrophil activation in normoglycemic rats (Ueki et al 2007). Since these results strongly suggest that monosaccharides may exert an inhibitory action on neutrophil activation, we screened for familiar monosaccharides except for rare sugars with serum creatinine concentration after reperfusion.…”