Inhibitory Effect of Extracts of Platycodon grandiflorum (the Ballon Flower) on Oxidation and Nitric Oxide Production

Jang, Joo-Ri; Hwang, Seong-Yeon; Lim, Sangwoo

doi:10.11002/kjfp.2011.18.1.065

Cited by 27 publications

(5 citation statements)

References 17 publications

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“…Previous studies conducted with other natural products, such as sowthistle ( Ixeris dentate Nakai ), 31 Dahurian rose ( Rosa davurica Pall . ), 32 and balloon flower ( Pladycodon grandiflorum ), 33 also exhibited the high antioxidant activities of the ethyl acetate and butanol solvent fractions. The ethyl acetate fraction of Dendropanax morbifera Léveille , in particular, contains a high amount of catethin; therefore, it showed high antioxidant activity.…”

Section: Discussionmentioning

confidence: 99%

Antimicrobial, Antioxidant and Cytotoxic Activities of Dendropanax morbifera Léveille extract for mouthwash and denture cleaning solution

et al. 2016

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PURPOSEThe purpose of this study was to analyze the antimicrobial, antioxidant activity and cytotoxicity of Dendropanax morbifera Léveille extract for assessing whether Dendropanax morbifera Léveille can be used for the development of natural mouthwash and denture cleaning solution.MATERIALS AND METHODSThe extract was obtained from branches of Dendropanax morbifera Léveille. The solvent fractions were acquired by fractionating Dendropanax morbifera Léveille extract using n-hexane, ethyl acetate, chloroform and butanol solvent. Paper disc test was used to evaluate the antimicrobial and antifungal activity of Dendropanax morbifera Léveille extract and solvent fractions against Streptococcus mutans and Candida albicans. The analysis of antioxidant activity was carried out through DPPH radical scavenging assay. The cytotoxicity of Dendropanax morbifera Léveille extract was analyzed through MTT assay using normal human oral keratinocytes.RESULTSDendropanax morbifera Léveille extract showed antimicrobial activity against Streptococcus mutans and especially Candida albicans. The solvent fractions of Dendropanax morbifera Léveille showed strong antimicrobial activity against Streptococcus mutans and Candida albicans in n-hexane and butanol solvent fraction, respectively. Dendropanax morbifera Léveille extract also showed outstanding antioxidant activity. Butanol, ethyl acetate, and chloroform solvent fraction of Dendropanax morbifera Léveille tended to have increased antioxidant activity as the concentration increased. Dendropanax morbifera Léveille extract showed high cell survival rate in cytotoxicity test.CONCLUSIONDendropanax morbifera Léveille extract turned out to have antimicrobial, antioxidant activity and cytophilicity. Based on these results, it is expected that Dendropanax morbifera Léveille is applicable as an ingredient for natural mouthwash and denture cleanser.

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Section: Discussionmentioning

confidence: 99%

Antimicrobial, Antioxidant and Cytotoxic Activities of Dendropanax morbifera Léveille extract for mouthwash and denture cleaning solution

et al. 2016

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“…Nitric oxide is a substance that mediates intercellular action and is produced by immune stimulation in macrophages or hepatocytes [ 20 ]. In this study, we investigated the effect of UPT enzyme extracts on NO production on LPS-induced RAW 264.7 cells for 0–48 h. As a result, the amount of NO secreted by LPS stimulation was 15.55 ± 1.30 μM, and the NO production was highly suppressed by the UPT enzymatic extracts treatment.…”

Section: Resultsmentioning

confidence: 99%

Characterization of Undaria pinnatifida Root Enzymatic Extracts Using Crude Enzyme from Shewanella oneidensis PKA 1008 and Its Anti-Inflammatory Effect

Jeong

Lee

et al. 2020

Journal of Microbiology and Biotechnology

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This study investigated the characterization and functionality of Undaria pinnatifida root (UPT) extracts, degraded using a crude enzyme from Shewanella oneidensis PKA1008. To obtain the optimum degrading conditions, the UPT was mixed with alginate degrading enzymes from S. oneidensis PKA 1008 and was incubated at 30°C for 0, 3, 6, 12, 24, and 48 h. The alginate degrading ability of these enzymes was then evaluated by measuring the reducing sugar, viscosity, pH and chromaticity. Enzymatic extract at 24 h revealed the highest alginate degrading ability and the lowest pH value. As the incubation time increased, the lightness (L *) also decreased and was measured at its lowest value, 39.84, at 12 hours. The redness and yellowness increased gradually to 10.27 at 6 h and to 63.95 at 3 h, respectively. Moreover, the alginate oligosaccharides exhibited significant anti-inflammatory activity. These results indicate that a crude enzyme from S. oneidensis PKA 1008 can be used to enhance the polysaccharide degradation of UPT and the alginate oligosaccharides may also enhance the anti-inflammatory effect.

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“…Chang et al [19] reported the constraining effect of NO production of Platycodon grandiflorum. Ko et al [20] reported that Platycodon grandiflorum would inhibit the secretion of inflammatory cytokine such as TNF-α, IL-6 and IL-8.…”

Section: ] No Generation Inhibition Ratementioning

confidence: 99%

Antibacterial and anti-inflammatory effects of Platycodon grandiflorum extracts

Kim¹

2014

Journal of Digital Convergence

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An t ib a ct er ia l a n d an t i-in flam m a t or y effect s of P la tycodon gr a n difloru m ext r a ct s J u n g K im Dep t . of Dent a l H ygien e, Su won W omen's Univer sit y 도라지 추출물의 항균작용 및 항염작용 김 정 수원여자대학교 치위생과 Abstract This study investigated the impact on S. mutans와 C. albicans in order to reveal the antimicrobial activity of Platycodon grandiflorum extracts. In addition, it examined NO generation inhibition rate in accordance with the extract concentration from Raw 264.7 cell in order to find out anti-inflammatory activation. As for the study materials, domestically made 100% Platycodon grandiflorum powder was utilized. As for the experimental strain, S. mutans KCTC 3065 and C. albicalns KCTC 7965 were utilized. Consequently, this study obtained the following results. Growth inhibition rate of S. mutans became significantly higher with higher concentration of Platycodon grandiflorum extracts. Growth inhibition rate of C. albicans became significantly higher with higher concentration of Platycodon grandiflorum extracts. NO generation inhibition rate was found to be 29.2% and 26.1% respectively when adding Platycodon grandiflorum extract with the concentration of 10 and 20 μg/ml in Raw 264.7 cells. These results mean that Platycodon grandiflorum could be leveraged as antimicrobial and anti-inflammatory substance.

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Inhibitory Effect of Extracts of Platycodon grandiflorum (the Ballon Flower) on Oxidation and Nitric Oxide Production

Cited by 27 publications

References 17 publications

Antimicrobial, Antioxidant and Cytotoxic Activities of Dendropanax morbifera Léveille extract for mouthwash and denture cleaning solution

Antimicrobial, Antioxidant and Cytotoxic Activities of Dendropanax morbifera Léveille extract for mouthwash and denture cleaning solution

Characterization of Undaria pinnatifida Root Enzymatic Extracts Using Crude Enzyme from Shewanella oneidensis PKA 1008 and Its Anti-Inflammatory Effect

Antibacterial and anti-inflammatory effects of Platycodon grandiflorum extracts

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