Antimicrobial, Antioxidant and Cytotoxic Activities of Dendropanax morbifera Léveille extract for mouthwash and denture cleaning solution

Abstract

PURPOSEThe purpose of this study was to analyze the antimicrobial, antioxidant activity and cytotoxicity of Dendropanax morbifera Léveille extract for assessing whether Dendropanax morbifera Léveille can be used for the development of natural mouthwash and denture cleaning solution.MATERIALS AND METHODSThe extract was obtained from branches of Dendropanax morbifera Léveille. The solvent fractions were acquired by fractionating Dendropanax morbifera Léveille extract using n-hexane, ethyl acetate, chloroform and butanol solvent. Paper disc test was used to evaluate the antimicrobial and antifungal activity of Dendropanax morbifera Léveille extract and solvent fractions against Streptococcus mutans and Candida albicans. The analysis of antioxidant activity was carried out through DPPH radical scavenging assay. The cytotoxicity of Dendropanax morbifera Léveille extract was analyzed through MTT assay using normal human oral keratinocytes.RESULTSDendropanax morbifera Léveille extract showed antimicrobial activity against Streptococcus mutans and especially Candida albicans. The solvent fractions of Dendropanax morbifera Léveille showed strong antimicrobial activity against Streptococcus mutans and Candida albicans in n-hexane and butanol solvent fraction, respectively. Dendropanax morbifera Léveille extract also showed outstanding antioxidant activity. Butanol, ethyl acetate, and chloroform solvent fraction of Dendropanax morbifera Léveille tended to have increased antioxidant activity as the concentration increased. Dendropanax morbifera Léveille extract showed high cell survival rate in cytotoxicity test.CONCLUSIONDendropanax morbifera Léveille extract turned out to have antimicrobial, antioxidant activity and cytophilicity. Based on these results, it is expected that Dendropanax morbifera Léveille is applicable as an ingredient for natural mouthwash and denture cleanser.

The Clinical Effects of Dendropanax Morbifera on Postmenopausal Symptoms: Review Article

“…Among them, DM is traditional medicinal plants found in South Korea and is mainly distributed in the Jeju Island, and near of the Korea coastline ( Table 2 ). 12 …”

Anti-osteoporotic effects of mixed compositions of extracellular polymers isolated from Aureobasidium pullulans and Textoria morbifera in ovariectomized mice

“…Textoria morbifera (TM) Nakai mainly grows in Jeju-do Island and along the Korean southwestern coastline [ 16 , 17 ]. It has been used as an ingredient for traditional medicine and tea for immunological enhancement [ 16 – 18 ].…”

“…Textoria morbifera (TM) Nakai mainly grows in Jeju-do Island and along the Korean southwestern coastline [ 16 , 17 ]. It has been used as an ingredient for traditional medicine and tea for immunological enhancement [ 16 – 18 ]. Previously, TM extracts have exhibited numerous immunological activities, including anti-diabetic [ 19 ], antioxidant [ 20 ], anti-cancer [ 21 ], anti-insecticidal [ 22 ], anti-complementary effects, as well as antibiotic and medicinal effects for liver diseases [ 23 ].…”

Antiosteoporotic effects of 3:1 (g/g) mixed formulation of exopolymers purified fromAureobasidium pullulansSM-2001 andDendropanax morbiferaleaf extracts in ovariectomized rats

“…Dendropanax morbifera Léveille (Araliaceae) is a tree that grows mainly on Jeju Island and some portions of the Korean coastline along the southwestern sea (Kim, Lee, Kim, Heo, & Son, ; Kim, Park, et al, ). Traditionally, it has been used to prepare tea and medicine for liver disease and immunological enhancement (Kim, Lee, et al, ; Kim, Park, et al, ; Kim, Yim, et al, ).…”

“…Dendropanax morbifera Léveille (Araliaceae) is a tree that grows mainly on Jeju Island and some portions of the Korean coastline along the southwestern sea (Kim, Lee, Kim, Heo, & Son, ; Kim, Park, et al, ). Traditionally, it has been used to prepare tea and medicine for liver disease and immunological enhancement (Kim, Lee, et al, ; Kim, Park, et al, ; Kim, Yim, et al, ). Dendropanax morbifera (DM) extracts have been reported to exert various effects, including immune activation against cancer cells, antioxidant effects (Hyun et al, ; Lee, Park, Hwang, Kim, & Lee, ), diabetes treatment and prevention (Moon, ), and insecticidal effects (Chung, Kim, Park, & Moon, ).…”