“…Consequently, several studies have proposed anti-metastatic agents, such as migrastatics (i.e., anti-migration drugs) 8 or matrix metalloproteinase inhibitors (MMPIs), 9 to intervene in the occurrence of initial metastasis. Notably, lanthanides, including europium (Eu) ions, have shown potential in exhibiting effects similar to migrastatics and MMPIs, 10,11 with Eu ions demonstrating particularly promising inhibitory efficacy. 12 However, our preliminary study suggests that the use of Eu ions dissociated from water-soluble Eu-containing compounds, administered via the intravenous route, may present challenges due to their poor tumor-targeting nature and potential hemocompatibility issues.…”