Inhibitory effect of liposome-encapsulated penicillin G on growth of Listeria monocytogenes in mouse macrophages.

Nanoengineered Drug Delivery Systems for Enhancing Antibiotic Therapy

“…The intracellular residence of bacteria may complicate effective treatment of bacterial infections. In subsequent studies, other research expanded this area, and reported specifically on intracellular killing of various classes of sensitive and resistant bacteria by liposomal formulations using drugs such as dihydrostreptomycin, cephalothin, penicillin‐G, vancomycin, and teicoplanin . In addition to intracellular targeting, liposomes have been studied for topical applications, with reports indicating that topical infections of soft tissues by Pseudomonas aeruginosa can be effectively treated by liposomal tobramycin–silver sulfadiazine …”