Inhibitory Effect of Pelargonidin on Secretory Group IIA Phospholipase A2

Lee, In-Chul; Bae, Jong‐Sup

doi:10.1177/1934578x1801300811

Natural Product Communications

2018

DOI: 10.1177/1934578x1801300811

|View full text |Cite

Inhibitory Effect of Pelargonidin on Secretory Group IIA Phospholipase A2

In-Chul Lee

Jong‐Sup Bae

Abstract: The expression of secretory group IIA phospholipase A2 (sPLA2-IIA) has been shown to be elevated in various inflammatory diseases, and lipopolysaccharide (LPS) up-regulates the expression of sPLA2-IIA in human umbilical vein endothelial cells (HUVECs). Pelargonidin (PEL) is a well-known red pigment found in plants, and has been reported as having important biological activities that are potentially beneficial for human health. Here, PEL was examined for its effects on the expression and activity of sPLA2-IIA i… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2019

2023

Publication Types

Select...

Article2

Relationship

Self Cite0

Independent2

Authors

Journals

Cited by 2 publications

References 34 publications

(43 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

Anti-Septic Effects of Cudratricusxanthone A Against HMGB1-Mediated Septic Responses

Yang

Lee

et al. 2019

Natural Product Communications

View full text Add to dashboard Cite

Cudratricusxanthone A (CTXA), a natural bioactive compound extracted from the roots of Cudrania tricuspidata Bureau, is known to possess hepatoprotective, antiproliferative, and anti-inflammatory activities. Inhibition of high-mobility group box 1 (HMGB1) and restoration of endothelial integrity is emerging as an attractive therapeutic strategy in the management of severe sepsis or septic shock. Here, we examined the effects of CTXA on HMGB1-mediated barrier disruptive responses and survival rate in a mouse sepsis model. The anti-inflammatory activities of CTXA were monitored by the effects on lipopolysaccharide-or cecal ligation and puncture (CLP)-mediated release of HMGB1. In addition, treatment with CTXA reduced CLP-induced mouse mortality in vivo. Our results indicate that CTXA could be a candidate for a therapeutic agent for various severe vascular inflammatory diseases via the inhibition of the HMGB1 signaling pathway.

show abstract

Anti-Septic Effects of Cudratricusxanthone A Against HMGB1-Mediated Septic Responses

Yang

Lee

et al. 2019

Natural Product Communications

View full text Add to dashboard Cite

show abstract

Single anthocyanins effectiveness modulating inflammation markers in obesity: dosage and matrix composition analysis

Fragoso-Medina,

López Vaquera,

Domínguez-Uscanga

et al. 2023

Front. Nutr.

View full text Add to dashboard Cite

Anthocyanins (ACNs) are phytochemicals with numerous bioactivities, e.g., antioxidant and anti-inflammatory. Health benefits from consuming ACN-rich foods, extracts, and supplements have been studied in clinical trials (CT). However, the individual effect of single ACNs and their correlation with doses and specific bioactivities or molecular targets have not been thoroughly analyzed. This review shows a recompilation of single anthocyanins composition and concentrations used in CT, conducted to investigate the effect of these anti-inflammatory derivatives in obese condition. Single anthocyanin doses with changes in the levels of frequently monitored markers were correlated. In addition, the analysis was complemented with reports of studies made in vitro with single ACNs. Anthocyanins' efficacy in diseases with high baseline obesity-related inflammation markers was evidenced. A poor correlation was found between most single anthocyanin doses and level changes of commonly monitored markers. Correlations between cyanidin, delphinidin, and pelargonidin derivatives and specific molecular targets were proposed. Our analysis showed that knowledge of specific compositions and anthocyanin concentrations determined in future studies would provide more information about mechanisms of action.

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Inhibitory Effect of Pelargonidin on Secretory Group IIA Phospholipase A2

Cited by 2 publications

References 34 publications

Anti-Septic Effects of Cudratricusxanthone A Against HMGB1-Mediated Septic Responses

Anti-Septic Effects of Cudratricusxanthone A Against HMGB1-Mediated Septic Responses

Single anthocyanins effectiveness modulating inflammation markers in obesity: dosage and matrix composition analysis

Contact Info

Product

Resources

About