Inhibitory Effect of Traditional Turkish Folk Medicines on Aldose Reductase (AR) and Hematological Activity, and on AR Inhibitory Activity of Quercetin-3-O-methyl Ether Isolated from Cistus laurifolius L.

Abstract

The inhibitory effects of 40 extracts prepared from 38 traditional Turkish folk medicines on human aldose reductase (h-AR) and hematological activity were investigated. Seven plants containing 5 species of Cistus genus exhibited a potent inhibition of h-AR. Ferulago amani (root) inhibited the platelet aggregation induced by sodium arachidonate, while C. laurifolius (fruit) was found to possess strong inhibition in the blood coagulation assay. An AcOEt extract derived from the leaf of C. laurifolius was purified to isolate three known flavonoids. The activity of one, quercetin-3-O-methyl ether, was found to be as potent as that of eparlestat, which is known to be a remedy for treating complications associated with diabetes.

Inhibitory Effects of Isorhamnetin-3-O-.BETA.-D-glucoside from Salicornia herbacea on Rat Lens Aldose Reductase and Sorbitol Accumulation in Streptozotocin-Induced Diabetic Rat Tissues

“…There are many flavonoids having an inhibitory effect on AR. [15][16][17][18] In a previous paper, we reported the antidiabetic activities of tectorigenin isolated from Belamcanda chinensis. 19) In fact, up to now there have been few reports on the antidiabetic activities in vivo of flavonoidal glycosides.…”

Identification of novel downstream targets of platelet glycoprotein VI activation by differential proteome analysis: implications for thrombus formation

“…Interestingly, inhibitors of AR have recently been described to influence platelet function in rats. 26,27 Therefore, we first focused on the role of AR for GPVI-induced platelet activation. We measured AR activity in platelets in response to GPVI ligation using a recently described assay.…”

Aldose reductase inhibitory activity of quercetin from the stems ofRhododendron mucronulatumfor.albiflorum

“…Thereby, AR promotes the generation of osmotic and oxidative stress. Among them, oxidative stress can cause diseases, including diabetes-related complication and disorders, including retinopathy, neuropathy, and nephropathy (Enomoto et al 2004;Jung et al 2007;Ha et al 2009;Jung et al 2011). The AR accumulation can cause numerous disorders and, therefore, the discovery of AR inhibitors is crucial.…”