Inhibitory effect of visfatin and leptin on human and rat myometrial contractility

Mumtaz, Sadaf; Alsaif, Seham; Wray, Susan; Noble, Karen

doi:10.1016/j.lfs.2015.01.020

Cited by 48 publications

(42 citation statements)

References 65 publications

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“…One in vitro study found that myometrial strips from obese women contract with less frequency and amplitude than those from normal-weight women. 15 Furthermore, adipokines such as leptin and visfatin, 16,17 as well as low-density lipoprotein cholesterol 18 have been shown to inhibit the contractility of myometrial strips in vitro. Translating these in vitro studies into clinically relevant results, however, is challenging due to the many factors that contribute to a successful vaginal delivery.…”

Section: Labor Progressionmentioning

confidence: 99%

Intrapartum Management of the Obese Gravida

Carpenter¹

2016

Clinical Obstetrics &Amp; Gynecology

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Obese women are at increased risk for multiple labor abnormalities, including postdates pregnancy, failed induction of labor, prolonged labor, cesarean delivery, and postpartum hemorrhage (PPH). Prolonged labor among obese women is confined to the first stage of labor. In the setting of reassuring fetal and maternal status, increased time to progress in the first stage of labor should be allowed. Uterine atony occurs more frequently in obese women and vigilance in the prevention of PPH is critical. There is a lack of high-quality data to guide the management of induction, labor, and PPH prevention among obese women.

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Section: Labor Progressionmentioning

confidence: 99%

Intrapartum Management of the Obese Gravida

Carpenter¹

2016

Clinical Obstetrics &Amp; Gynecology

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“…A reduced frequency and amplitude of contractions in myometrium from obese women compared to myometrium from normal weight women have been demonstrated in vitro (55). It has also been shown that leptin has an in vitro cumulative inhibitory effect on human myometrial contractions (spontaneous and oxytocin induced) (92,94). The combination of these in vitro findings, the high leptin levels identified in obese pregnant women and the increased risk for a prolonged duration of labor led to our hypothesis.…”

Section: Leptin and Duration Of Labormentioning

confidence: 62%

“…However, several authors have analyzed the effect of leptin on myometrial muscle cells in vitro and have suggested that leptin may play a role in the regulation of myometrial activity and obesity related parturition complications (90)(91)(92)(93)(94). Moynihan el al.…”

Section: Leptin and Myometrial Contractilitymentioning

confidence: 99%

Maternal obesity, duration of labor and the role of leptin

Carlhäll¹

2018

Linköping University Medical Dissertations

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Background: The prevalence of obesity substantially increases in pregnant women. Maternal obesity is associated with adverse maternal and neonatal outcomes. The increased risk for cesarean section present in obese women has been related to potential impaired uterine contractility. The mechanism that underlies this theory is not clear. In vitro studies have shown that leptin, produced by adipose tissue and the placenta, exerts an inhibitory effect on myometrial contractility. The aim of this thesis was to evaluate the labor process in relation to maternal body mass index (BMI) and the clinical role of leptin in this process.

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“…Two independent German cohort studies provided evidence on the robust association among GWG, fetal-maternal leptin, and fetal development, along with the long-term consequences of hypo- and hyper-leptinemia during pregnancy (19). Leptin was demonstrated to have relaxing effect on isolated human and rat myometria (62,63). The dysregulation of leptin also can lead to infertility.…”

Section: Metabolic Regulation Of Human Myometrial Function During Prementioning

confidence: 99%

“…In addition, it promotes cervical collagen synthesis in late gestation, which can also result in delayed labor (50). Leptin also inhibits spontaneous and agonist induced uterine contractions on isolated human and rat myometrium (62,63). …”

Section: Uterine Contractility In Obese Womenmentioning

confidence: 99%

Obesity in pregnancy: a novel concept on the roles of adipokines in uterine contractility

et al. 2017

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Obesity is a global health problem even among pregnant women. Obesity alters quality of labor, such as preterm labor, prolonged labor, and higher oxytocin requirements in pregnant women. The most important factors to play a role in the altered gestational period and serve as drug targets to treat the consequences are female sexual hormones, calcium channels, adrenergic system, oxytocin, and prostaglandins. However, we have limited information about the impact of obesity on the pregnant uterine contractility and gestation time. Adipose tissue, which is the largest endocrine and paracrine organ, especially in obesity, is responsible for the production of adipokines and various cytokines and chemokines, and there are no reliable data available describing the relation between body mass index, glucose intolerance, and adipokines during pregnancy. Recent data suggest that the dysregulation of leptin, adiponectin, and kisspeptin during pregnancy contributes to gestational diabetes mellitus and pre-eclampsia. A preclinical method for obese pregnancy should be developed to clarify the action of adipokines and assess their impact in obesity. The deeper understanding of the adipokines-induced processes in obese pregnancy may be a step closer to the prevention and therapy of preterm delivery or prolonged pregnancy. Gestational weight gain is one of the factors that could influence the prenatal development, birth weight, and adiposity of newborn.

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Inhibitory effect of visfatin and leptin on human and rat myometrial contractility

Cited by 48 publications

References 65 publications

Intrapartum Management of the Obese Gravida

Intrapartum Management of the Obese Gravida

Maternal obesity, duration of labor and the role of leptin

Obesity in pregnancy: a novel concept on the roles of adipokines in uterine contractility

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