Inhibitory Effect of Volatile Fatty Acids on GRF-Induced GH Secretion in Sheep.

Matsunaga, Naofumi; Nam, K. T.; Kuhara, Tetsuya; Oda, Shunsuke; Ohneda, Akira; Sasaki, Yoshiyuki

doi:10.1507/endocrj.40.529

Cited by 19 publications

(19 citation statements)

References 27 publications

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“…A simultaneous increase in both hormones seems to be a typical endocrine feature in pre-weaning ruminant animals, but this observation remains to be clarified. Butyrate (or SCFAs) injection in either the jugular blood circulation or the rumen reduced plasma GH concentrations in vivo (Matsunaga et al 1993(Matsunaga et al , 1999. These responses may be due to the suppression in basal and GH-releasing-hormone-induced cellular calcium ion concentrations in pituitary somatotrophs (Katoh 1995, Katoh et al 1996, Katoh & Ishiwata 1998, Ishiwata et al 2000, 2005.…”

Section: Discussionmentioning

confidence: 99%

Effects of Na-butyrate supplementation in milk formula on plasma concentrations of GH and insulin, and on rumen papilla development in calves

Kato¹,

Sato²,

Chida³

et al. 2011

Journal of Endocrinology

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Although the growth-promoting action of sodium-butyrate (Na-butyrate) used as a feed additive has been observed in calves and pigs, the precise mechanisms involved remain to be clarified. In this study, pre-weaning calves were given milk formula (MF) supplemented with butyrate for 6 weeks to investigate its effects on postprandial changes in the plasma concentrations of metabolic hormones, and, simultaneously, on growth performance, the weight of the digestive organs and rumen papilla development. Ingestion of MF increased (P!0 . 05) the plasma concentrations of GH and insulin as well as the glucose level, but decreased the non-esterified fatty acid concentration. Na-butyrate supplementation in MF or in lactose solution (with the same quantity of lactose contained in the MF, 5%) suppressed the increase in plasma insulin and GH concentrations, and the plasma IGF1 level was not changed. The length of the rumen papilla and the weight of the perirenal fat tended to increase in the calves fed with Na-butyrate-supplemented MF, but the weight of the liver, spleen, and stomach were not changed. In addition, there was no difference in the expression of mRNA for sodiumdependent glucose transporter-1 in the small intestinal epithelial tissues. We conclude that the accelerated growth performance related to the intake of Na-butyrate used as a feed additive reported previously in several species is partly due to improved insulin sensitivity and a better digestive functional development. These data could be applicable to animal and human nutrition.

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Section: Discussionmentioning

confidence: 99%

Effects of Na-butyrate supplementation in milk formula on plasma concentrations of GH and insulin, and on rumen papilla development in calves

Kato¹,

Sato²,

Chida³

et al. 2011

Journal of Endocrinology

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“…The actual rate of propionate and butyrate was 20.8,umol kg-1 min-1 in this infusion rate, but in our previous study, GRF-induced GH secretion was reduced by intravenous infusion of propionate or butyrate at the 10 and 30 ,umol kg-1 min-1 infusion rate [7]. This conflict might be attributed to the difference in the infusion route.…”

Section: Infusion Experimentsmentioning

confidence: 73%

“…In our previous report, because intravenous propionate and butyrate infusion suppressed GRFinduced GH secretion in sheep [7], it is possible that VFA absorbed from their rumen plays a role in decreasing GH secretion on their somatotroph in this species. But despite these effects on plasma GH, systemic plasma VFA, especially the propionate and butyrate concentrations, do not normally increase to levels that will affect the secretion of plasma GH, since propionate and butyrate are largely removed from the blood by the liver in a single passage [9].…”

Section: Infusion Experimentsmentioning

confidence: 82%

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Effect of Mesenteric Venous Volatile Fatty Acids (VFA) Infusion on GH Secretion in Sheep.

et al. 1997

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Abstract. The effects of mesenteric venous infusion of acetate, propionate and butyrate mixture (20.3, 40.5 and 81.0 ,umol kg-i mini over 4 h) on the secretion of GH was examined to investigate the effects of an increase in portal volatile fatty acids (VFA) on GH secretion in relation to inhibition of GH secretion after feeding in sheep. The mesenteric venous infusion at the rate of 40.5 tmol kg-i mini increased the portal plasma VFA concentration within the approximate physiological range after feeding. Plasma GH was noticeably suppressed only at the infusion rate of 81.0 tmol kg-i mini and the change in the mean concentration from the base line was significantly less than in the control. Although GRF injection rapidly increased plasma GH, the change in the mean concentration from the base line tended to suppress only at the infusion rate of 81.0 µmol kg-i min-i. Plasma FFA was suppressed in a dose-dependent manner after VFA infusion. The change in the mean concentration from the base line was significantly suppressed only at the infusion rate of 81.0 pmol kg' mini relative to the control infusion, but plasma glucose was unchanged by VFA infusion. It is concluded that because the increase in the portal plasma VFA concentration within the range of feeding did not suppress GH secretion, VFA absorbed by the digestive tract may not play a significant role in suppressing GH secretion after feeding in sheep.

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“…The release of insulin induced by intravenous propionate infusion was blocked by atropine infusion while the release of glucagon was blocked by phentolamine infusion in rams (Sano et al 1993). The release of GH in response to growth hormone releasing factor was markedly suppressed by intraruminal infusion of a VFA mixture in sheep, and the suppression was mediated via the parasympathetic nervous system (Matsunaga et al 1993;. Therefore, the propionate produced in the rumen and absorbed from the gut possibly controls the release of insulin, glucagon and GH via the autonomic nervous system.…”

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confidence: 94%

Autonomic regulation of plasma insulin, glucagon and growth hormone responses to feeding in sheep fed a diet supplemented with calcium propionate

et al. 1999

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. 1999. Autonomic regulation of plasma insulin, glucagon and growth hormone responses to feeding in sheep fed a diet supplemented with calcium propionate. Can. J. Anim. Sci. 79: [449][450][451][452][453][454][455][456]. The role of the autonomic nervous system in the regulation of plasma insulin, glucagon and growth hormone (GH) responses to supplemental propionate was investigated in rams. The rams were fed alfalfa hay cubes supplemented with 10 mmol kg -1 d -1 of calcium propionate. Saline, phentolamine, propranolol, atropine or hexamethonium were separately infused for 135 min starting 15 min before feeding. During saline infusion, the concentrations of plasma insulin and glucagon increased (P < 0.05) after the initiation of feeding, whereas plasma GH concentrations tended to decrease. Plasma insulin responses to feeding tended to be reduced by atropine and hexamethonium infusions. Plasma glucagon responses were abolished by atropine, hexamethonium and phentolamine infusions. It is suggested that in rams fed a propionate supplemented diet, the release of insulin and glucagon increases in response to feeding. Insulin release is mediated by activation of the parasympathetic nervous system, although responses were not significant in this study, while glucagon release is mediated both by activation of the parasympathetic nervous system and by the adrenergic α-receptors of the sympathetic nervous system. This study does not support a role for the autonomic nervous system in the regulation of GH release.Key words: Autonomic nervous system, insulin, glucagon, growth hormone, propionate, sheep Sano, H., Mori, Y., Takahashi, H. et Terashima, Y. 1999. Régulation autonome des réponses de l'insuline, du glucagon et de l'hormone de croissance dans le plasma chez des moutons recevant une alimentation complémentée avec du propionate de calcium. Can. J. Anim. Sci. 79: 449-456. Nous avons étudié chez des béliers le rôle du système nerveux autonome dans la régu-lation des réponses de l'insuline, du glucagon et de l'hormone de croissance (GH) dans le plasma sanguin à la présence d'un supplément de propionate dans l'aliment. Les béliers recevaient du foin de luzerne en cubes, enrichi de 10 mmol de propionate de calcium par kg d'aliment, par jour. Un soluté salin (témoin), de la phentolamine, du propranolol, de l'atropine ou de l'hexaméthonium étaient infusés séparément dans la jugulaire pendant 135 min à partir de 15 min avant le repas. L'infusion salée donnait lieu à un accroissement (P < 0,05) des concentrations plasmatiques d'insuline et de glucagon des le début du repas, tandis que les concentrations de GH suivaient une tendance à la baisse. Les réponses de l'insuline plasmatique à l'ingestion d'aliments parraissaient atténuées par les infusions d'atropine et d'hexaméthonium. Ces deux bloquants et la phentolamine effaçaient toute réponse du glucagon. Les résultats donnent à penser que chez les béliers recevant l'aliment complémenté au propionate les décharges d'insuline et de glucagon augmentent sous l'effet de l'alimentatio...

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Inhibitory Effect of Volatile Fatty Acids on GRF-Induced GH Secretion in Sheep.

Cited by 19 publications

References 27 publications

Effects of Na-butyrate supplementation in milk formula on plasma concentrations of GH and insulin, and on rumen papilla development in calves

Effects of Na-butyrate supplementation in milk formula on plasma concentrations of GH and insulin, and on rumen papilla development in calves

Effect of Mesenteric Venous Volatile Fatty Acids (VFA) Infusion on GH Secretion in Sheep.

Autonomic regulation of plasma insulin, glucagon and growth hormone responses to feeding in sheep fed a diet supplemented with calcium propionate

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