Inhibitory effect of zinc-containing desensitizer on bacterial biofilm formation and root dentin demineralization

Saad, Ahmed; Nikaido, Toru; Abdou, Ahmed; Matin, Khairul; Burrow, Michael F.; Tagami, Junji

doi:10.4012/dmj.2018-352

Cited by 24 publications

(18 citation statements)

References 36 publications

(45 reference statements)

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“…For caries, Rahman et al reported that if calcium in hydroxyapatite crystals is replaced by zinc, the solubility of hydroxyapatite crystals will be increased [7]. On the other hand, Saad et al [9] reported in their in vitro study that zinc inhibited the formation of biofilm and dentin demineralization.…”

Section: Discussionmentioning

confidence: 99%

Effects of Zinc, Iron, and Copper on Bovine Enamel Erosion Evaluated Using Transverse Microradiography

Yamada¹,

Watanabe²,

Hara³

et al. 2020

Health

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Objective: This study aimed to clarify the effect of trace elements on enamel erosion due to citric acid eliminating other factors that can affect enamel erosion. Method: Forty enamel specimens were obtained by embedding bovine enamel blocks into a quick cure resin. Half of the enamel surface of the specimens was covered with nail varnish. The specimens were randomly divided into control (Ct), zinc (Zn), iron (Fe), and copper (Cu) groups and immersed in 1% citric acid solution, 1% citric acid solution with 10 mmol/L zinc, 1% citric acid solution with 10 mmol/L iron, or 1% citric acid solution with 10 mmol/L copper, respectively, at 37˚C for 5 h. After immersion, the demineralized lesion depth was measured using transverse microradiography (TMR) and compared between groups using one-way analysis of variance and Tukey's test. Results: The lesion depth was significantly higher in the Zn (218.9 ± 88.5 µm) group than that in the Ct group (116.3 ± 22.1 µm) (p < 0.01). Conclusion: It was suggested that zinc has decalcification properties when consumed with citric acid, while iron and copper don't have such properties.

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Section: Discussionmentioning

confidence: 99%

Effects of Zinc, Iron, and Copper on Bovine Enamel Erosion Evaluated Using Transverse Microradiography

Yamada¹,

Watanabe²,

Hara³

et al. 2020

Health

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“…Although the SS group exhibited nearly the same failure mode as that in the Cont(#4000), it is not currently known why the bond strength was lower. In the CS group, it is thought that deposited calcium fluoride or calcium phosphate or released zinc ions [24][25][26][27] may have suppressed the etching effect of the acidic monomer of the bonding resin 26) , thereby decreasing the bonding strength, demonstrating the failure at the interface between the dentin and the bonding resin. However, the NS group exhibited nearly the same bond strength and failure mode (cohesive failure inside the bonding resin, cohesive failure inside the resin and cohesive failure inside the dentin) as in the Cont(#4000) group, and the interfacial failure was found in some specimens.…”

Section: Bond Strength Immediately After Application and 7 Days Latermentioning

confidence: 99%

Effects of Various Desensitizing Agents on the Microtensile Bond Strength of a Hypersensitive Dentin Model Produced <i>in vitro</i> Using a One-step Self-etch System

Batzorig

Nakano

Murata

et al. 2021

J. Hard Tissue Biology.

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In the treatment of dentin hypersensitivity accompanying tooth substance defects such as wedge-shape defects, hypoesthesia can be achieved by applying a desensitizing agent before carrying out restoration using resin composite. However, almost no research has investigated the adhesion of resin to dentin coated with the latest desensitizing agents. Therefore, this study investigated the effects of various desensitizing agents on the adhesion of resin to dentin in combination with a 1-step self-etch system by using a hypersensitive dentin model in which the dentinal tubules were opened without etching and there was almost no smear layer on the intertubular dentin. Specimens with a #4000 polished dentin flat surface were ultrasonically cleaned for 60 min (15 min × 4 times). Then, the bond strength, failure modes, and micromorphology of surfaces coated with desensitizing agent to which resin was bonded immediately afterward and surfaces coated with desensitizing agent to which the resin was bonded after storage for 7 days in water were compared against a control to which no desensitizing agent was applied. The desensitizing agents used in this research did not promote adhesion of the resin immediately after application, but rather suppressed or completely obstructed it. Although deposits of microparticles and thin film material, which were observed immediately after application, tended to disappear after 7 days of storage in water, some of the desensitizing agents exhibited the same bond strength as the control, whereas other desensitizing agents did not show recovery of adhesion strength. Therefore, care is required when performing resin restoration immediately after application of a desensitizing agent, depending on the agent used, and caution must be exercised in the selection of desensitizing agents in the clinical setting.

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“…It acts as a desensitizer by inducing chemical occlusion of dentinal tubules and contains a novel functional filler which releases not only ions like calcium or fluorine but also zinc. Zinc is reported to reduce the demineralization of enamel and dentin, and inhibit dentin collagen degradation, plaque growth and biofilm formation (12,13).…”

Section: Introductionmentioning

confidence: 99%

The efficacy of a novel zinc-containing desensitizer CAREDYNE Shield on dentin hypersensitivity: study protocol for a pilot randomized controlled trial

Mizutani¹,

Mae²,

Ohira³

et al. 2020

Preprint

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Background: Dentin hypersensitivity (DH) is a condition characterized by short and sharp pain which will arise in response to tactile, chemical, thermal, evaporative or osmotic stimuli. The painful symptoms cause discomfort to the patients and decrease their quality of life. Recently, a novel zinc-containing desensitizer CAREDYNE Shield is developed. It is a new type of desensitizer which acts as a desensitizer by inducing chemical occlusion of dentinal tubules, and releases zinc ion for root caries prevention. However, the clinical effectiveness of CAREDYNE Shield on DH is still unclear. Therefore, the aim of this study is to evaluate the effectiveness of CAREDYNE Shield on DH by comparing with that of another desensitizer Nanoseal commonly used in Japan.Methods/Design: This study protocol is a two-arm parallel pilot randomized controlled trial. Forty DH patients will be randomly allocated into 2 groups. Participants in the intervention group will be treated with CAREDYNE Shield; participants in the control group will be treated with Nanoseal. Primary outcome is the reduction of pain intensity in response to air stimuli measured with 5-points verbal response scale from baseline to 4 weeks after the intervention and Fisher's exact test will be used for analysis.Discussion: CAREDYNE Shield can be casually applied to subgingival areas and proximal surfaces because it reacts with only tooth substance. Moreover, zinc is reported to reduce the demineralization of enamel and dentin and inhibit biofilm formation, plaque growth and dentin collagen degradation. Therefore, CAREDYNE Shield may be expected to become a novel useful desensitizer which act not only as a desensitizer but also as a root caries inhibitor.

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Inhibitory effect of zinc-containing desensitizer on bacterial biofilm formation and root dentin demineralization

Cited by 24 publications

References 36 publications

Effects of Zinc, Iron, and Copper on Bovine Enamel Erosion Evaluated Using Transverse Microradiography

Effects of Zinc, Iron, and Copper on Bovine Enamel Erosion Evaluated Using Transverse Microradiography

Effects of Various Desensitizing Agents on the Microtensile Bond Strength of a Hypersensitive Dentin Model Produced <i>in vitro</i> Using a One-step Self-etch System

The efficacy of a novel zinc-containing desensitizer CAREDYNE Shield on dentin hypersensitivity: study protocol for a pilot randomized controlled trial

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