Inhibitory effects and mechanisms of the anti-covid-19 traditional Chinese prescription, Keguan-1, on acute lung injury

Schaftoside inhibits 3CLpro and PLpro of SARS-CoV-2 virus and regulates immune response and inflammation of host cells for the treatment of COVID-19

“…administration of 2 mg/kg LPS ( Fig. 5 A) 40 . After 8 h LPS stimulation, histopathology of the lung tissue changed remarkably.…”

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Figure 5 The anti-inflammatory activities of schaftoside on lipopolysaccharide (LPS)-induced acute lung injury (ALI) mice. (A) Experimental scheme 40 . (B) Effects of schaftoside (10 and 20 mg/kg, i.g.)

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Traditional Chinese Medicine in Treatment of COVID-19 and Viral Disease: Efficacies and Clinical Evidence

“…After the virus infects the human body, immune abnormalities, cytokine storm, lung and cardiovascular injury would affect each other. Keguan-1 68 can reduce inflammation and pulmonary vascular endothelial injury. HSBDF and MXSG 66,69 can regulate inflammatory cytokines production and relieve lung injury through toll-like receptors signaling pathway.…”

Efficacy and safety of add-on Viola odorata L. in the treatment of COVID-19: A randomized double-blind controlled trial

“…COVID-19 causes a various range of symptoms from fatigue, myalgia, loss of appetite, diarrhea, fever, dyspnea, dry cough, and rhinorrhea to pneumonia or severe acute respiratory distress syndrome (ARDS)( Abebe et al, 2020 ; Figueiredo-Campos et al, 2020 ). Despite a large number of patients remain asymptomatic( Figueiredo-Campos et al, 2020 ), older people or patients with pre-existing high-risk health conditions such as respiratory or cardiovascular conditions, hypertension, diabetes, or immunocompromised states are at increased risk for developing severe complications like ARDS or uncontrolled inflammatory state leading to multiple organ failure, or death( Bai et al, 2022 ; Weiss and Murdoch, 2020 ). This situation demands widespread vaccination and innovation of new therapeutic methods ( Abebe et al, 2020 ).…”