Inhibitory effects and mode of antifungal action of isobavachalcone on Candida albicans growth and virulence factors

Yang, Longfei; Li, Wenmao; Zhong, Jianfeng; Liu, Xin

doi:10.1016/j.biopha.2024.117352

Biomedicine & Pharmacotherapy

2024

DOI: 10.1016/j.biopha.2024.117352

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Inhibitory effects and mode of antifungal action of isobavachalcone on Candida albicans growth and virulence factors

Longfei Yang,

Wenmao Li,

Jianfeng Zhong

et al.

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2024

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Isoalantolactone: a review on its pharmacological effects

Yang,

2024

Front. Pharmacol.

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Isoalantolactone (ISA) is a sesquiterpene lactone that could be isolated from Inula helenium as well as many other herbal plants belonging to Asteraceae. Over the past 2 decades, lots of researches have been made on ISA, which owns multiple pharmacological effects, such as antimicrobial, anticancer, anti-inflammatory, neuroprotective, antidepressant-like activity, as well as others. The anticancer effects of ISA involve proliferation inhibition, ROS overproduction, apoptosis induction and cell cycle arrest. Through inhibiting NF-κB signaling, ISA exerts its anti-inflammatory effects which are involved in the neuroprotection of ISA. This review hackled the reported pharmacological effects of ISA and associated mechanisms, providing an update on understanding its potential in drug development.

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Isoalantolactone: a review on its pharmacological effects

Yang,

2024

Front. Pharmacol.

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Inhibitory effects and mode of antifungal action of isobavachalcone on Candida albicans growth and virulence factors

Cited by 1 publication

References 53 publications

Isoalantolactone: a review on its pharmacological effects

Isoalantolactone: a review on its pharmacological effects

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