Inhibitory effects of 25 spices on heterocyclic aromatic amines formation in cooked pork patties

Wang, Kexin; Wang, Huali; Shan, Yanqin; Xu, Yang; Niu, Shubin; Li, Jing; Wang, Hao

doi:10.1007/s11694-022-01651-4

Cited by 5 publications

(1 citation statement)

References 47 publications

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“…This synergistic effect of SYN and NEO on GO/MGO further guided practical applications in the diet of fruits or plant extracts rich in SYN and NEO, such as orange juice in baking products, Pericarpium Citri Reticulatae in processed food as a flavor, and citrus extracts used as a weight loss commercial preparation …”

Section: Resultsmentioning

confidence: 99%

Scavenging Glyoxal and Methylglyoxal by Synephrine Alone or in Combination with Neohesperidin at High Temperatures

Liang,

Du,

Zhao

et al. 2024

J. Agric. Food Chem.

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α-Dicarbonyl compounds, such as glyoxal (GO) and methylglyoxal (MGO), are a series of chemical hazards that exist in vivo and in vitro, posing a threat to human health. We aimed to explore the scavenging effects on GO/MGO by synephrine (SYN) alone or in combination with neohesperidin (NEO). First, through LC−MS/MS, we confirmed that both SYN and NEO could effectively remove GO and form GO adducts, while NEO could also clear MGO by forming MGO adducts, and its ability to clear MGO was stronger than that of GO. Second, a synergistic inhibitory effect on GO was found when SYN and NEO were used in combination by using the Chou−Talalay method; on the other hand, SYN could promote NEO to clear more MGO, although SYN could not capture MGO. Third, after synthesizing four GO/MGO-adducts (SYN-GO-1, SYN-GO-3, NEO-GO-7, and NEO-MGO-2) and identifying their structure through NMR, strict correlations between the GO/MGO-adducts and the GO/MGO-clearance rate were found when using SYN and NEO alone or in combination. Furthermore, it was inferred that the synergistic effect between SYN and NEO stems from their mutual promotion in capturing more GO by the quantitative analysis of the adducts in the combined model. Finally, a study was conducted on flowers of Citrus aurantium L. var. amara Engl. (FCAVA, an edible tea) rich in SYN and NEO, which could serve as an effective GO and MGO scavenger in the presence of both GO and MGO. Therefore, our study provided well-defined evidence that SYN and NEO, alone or in combination, could efficiently scavenge GO/MGO at high temperatures, whether in the pure form or located in FCAVA.

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Section: Resultsmentioning

confidence: 99%