Inhibitory effects of [6]-gingerol, a major pungent principle of ginger, on phorbol ester-induced inflammation, epidermal ornithine decarboxylase activity and skin tumor promotion in ICR mice

Park, Kwang-Kyun; Chun, Kyung‐Soo; Lee, Jongmin; Lee, Sang Sup; Surh, Young‐Joon

doi:10.1016/s0304-3835(98)00081-0

Cited by 232 publications

(172 citation statements)

References 24 publications

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“…More recent studies have suggested that gingerols exhibit preventive activity against cancers of the skin [10] , pancreas [11] , gastrointestinal tract [12] , colon [13] , and breast [14] . Ginger can also effectively prevent nausea induced by cancer treatment [15] .…”

Section: Introductionmentioning

confidence: 99%

Pungent ginger components modulates human cytochrome P450 enzymes in vitro

Chen

Yue

et al. 2013

Acta Pharmacol Sin

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Aim: Ginger rhizome is used worldwide as a spicy flavor agent. This study was designed to explore the potential effects of pungent ginger components, 6-, 8-, and 10-gingerol, on human cytochrome P450 (CYP450) enzymes that are responsible for the metabolism of many prescription drugs. Methods: The activities of human CYP2C9, CYP2C19, CYP2D6, and CYP3A4 were analyzed using Vivid P450 assay kits. The mRNA expression of CYP3A4 in human hepatocellular carcinoma cell line HepG2 was measured using quantitative real-time PCR assay. Results: All three gingerols potently inhibited CYP2C9 activity, exerted moderate inhibition on CYP2C19 and CYP3A4, and weak inhibion on CYP2D6. 8-Gingerol was the most potent in inhibition of P450 enzymes with IC 50 values of 6.8, 12.5, 8.7, and 42.7 μmol/L for CYP2C9, CYP2C19, CYP3A4, and CYP2D6, respectively. By comparing the effects of gingerols on CYP3A4 with three different fluorescent substrate probes, it was demonstrated that the inhibition of gingerols on CYP3A4 had no substrate-dependence. In HepG2 cells, 8-gingerol and 10-gingerol inhibited, but 6-gingerol induced mRNA expression of CYP3A4. Conclusion: 6-, 8-, and 10-gingerol suppress human cytochrome P450 activity, while 8-and 10-gingerol inhibit CYP3A4 expression. The results may have an implication for the use of ginger or ginger products when combined with therapeutic drugs that are metabolized by cytochrome P450 enzymes.

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Section: Introductionmentioning

confidence: 99%

Pungent ginger components modulates human cytochrome P450 enzymes in vitro

Chen

Yue

et al. 2013

Acta Pharmacol Sin

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“…Several lines of evidence suggest that 6-gingerol is effective in the suppression of the transformation, hyperproliferation, and inflammatory processes that initiate and promote carcinogenesis, as well as the later steps of carcinogenesis, the angiogenesis and metastasis (Suzuki et al, 1997;Bode et al, 2001;Kim et al, 2005aKim et al, : 2005bLee et al, 2008). It is regarded as a promising chemopreventive dietary agent exhibiting inhibition of cyclooxygenase and lipoxygenase activities (Kiuchi et al, 1982(Kiuchi et al, : 1992Huang et al, 1991), apoptosis induction (Lee et al, 1998;Chauhan, 2002), and anti-tumorigenic effects (Park et al, 1998;Surh et al, 1999). The pungent vallinoids of ginger, [6]-gingerol and [6]-paradol, exhibit antiproliferation activity in liver, pancreatic, prostate, gastric, and leukemia cancer cells (Lee et al, 1998;Chen et al, 2007;Shukla and Singh, 2007).…”

Section: Introductionmentioning

confidence: 99%

“…It is regarded as a promising chemopreventive dietary agent exhibiting inhibition of cyclooxygenase and lipoxygenase activities (Kiuchi et al, 1982(Kiuchi et al, : 1992Huang et al, 1991), apoptosis induction (Lee et al, 1998;Chauhan, 2002), and anti-tumorigenic effects (Park et al, 1998;Surh et al, 1999). The pungent vallinoids of ginger, [6]-gingerol and [6]-paradol, exhibit antiproliferation activity in liver, pancreatic, prostate, gastric, and leukemia cancer cells (Lee et al, 1998;Chen et al, 2007;Shukla and Singh, 2007). Furthermore, [6]-shogaol has also been shown to exhibit anticancer activities against breast cancer through the inhibition of cell invasion reduction of matrix metalloproteinase-9 expression (via blockade of nuclear factor activation) (Ling et al, 2010), anti-proliferation activity (through disruption of microtubule network of non-small lung epithelium cancer) (Choudhury et al, 2010), and antiinvasion on human hepatocellular cell (Weng et al 2010).…”

Section: Introductionmentioning

confidence: 99%

Cytotoxicity, Toxicity, and Anticancer Activity of Zingiber Officinale Roscoe Against Cholangiocarcinoma

Plengsuriyakarn¹,

Viyanant²,

Eursitthichai³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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Cholangiocarcinoma (CCA) is an uncommon adenocarcinoma which arises from the epithelial cells of the bile ducts. The aim of the study was to investigate the cytotoxicity, toxicity, and anticancer activity of a crude ethanolic extract of ginger (Zingiber officinale Roscoe) against CCA. Cytotoxic activity against a CCA cell line (CL-6) was assessed by calcein-AM and Hoechst 33342 assays and anti-oxidant activity was evaluated using the DPPH assay. Investigation of apoptotic activity was performed by DNA fragmentation assay and induction of genes that may be involved in the resistance of CCA to anticancer drugs (MDR1, MRP1, MRP2, and MRP3) was examined by real-time PCR. To investigate anti-CCA activity in vivo, a total of 80 OV and nitrosamine (OV/ DMN)-induced CCA hamsters were fed with the ginger extract at doses of 1000, 3000, and 5000 mg/kg body weight daily or every alternate day for 30 days. Control groups consisting of 10 hamsters for each group were fed with 5-fluorouracil (positive control) or distilled water (untreated control). Median IC 50 (concentration that inhibits cell growth by 50%) values for cytotoxicity and anti-oxidant activities of the crude ethanolic extract of ginger were 10.95, 53.15, and 27.86 μg/ml, respectively. More than ten DNA fragments were visualized and up to 7-9 fold up-regulation of MDR1 and MRP3 genes was observed following exposure to the ethanolic extract of ginger. Acute and subacute toxicity tests indicated absence of any significant toxicity at the maximum dose of 5,000 mg/kg body weight given by intragastric gavage. The survival time and survival rate of the CCA-bearing hamsters were significantly prolonged compared to the control group (median of 54 vs 17 weeks). Results from these in vitro and in vivo studies thus indicate promising anticancer activity of the crude ethanolic extract of ginger against CCA with the absence of any significant toxicity. Moreover, MDR1 and MRP3 may be involved in conferring resistance of CCA to the ginger extract.

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“…It is also an analgesic, (11) an antivirus, (12) an antimigraine remedy, (13) and a bile secretion regulator, (11) and it has positive inotropic (14) and antitumor effects (15). It also appears that ginger prevents the synthesis of prostaglandin E2 and thromboxane B2 and affects serotonin receptors (16).…”

Section: Introductionmentioning

confidence: 99%

Morphological Effects of Hydroalcoholic Zingiber Officinalis Extract in the Murine Hippocampus of Male Rat Offspring

Ghodrati¹,

Mahmoodi²,

Shahidi³

et al. 2016

Avicenna J Neuro Psych Physio

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Background: The hippocampus is responsible for memory. A diet full of antioxidants improves brain damage and cognitive function. Regard the antioxidant effects of zingiber officinalis (ginger) and its flavonoids components. Objectives: The aim of this study was to evaluate the effect of the extract of ginger on memory by using hippocampus tissue of the male offspring of rats. Materials and Methods: In this study, 60 rats, 15 males and 45 females, were used. We separated pregnant female rats from males on the first day of pregnancy (determined by vaginal plug), and during days 16 -18 of pregnancy, via intraperitoneal injection, three groups received hydroalcoholic extract of ginger, with low (200 mg/kg bw), medium (400 mg/kg bw), and high (800 mg/kg bw) concentration doses. The control group did not receive anything, and the sham group received normal saline during these days. Then at day 50, the males offspring in each group were sacrificed, their brains were removed, and the hippocampus sections were prepared for microscopic studies. Data was analyzed by SPSS 20 and by using one-way ANOVA and then a Tukey post-test (P < 0.05 considered as the significance level). Results: This research showed that the number and thickness of pyramidal and granular layers of the CA1 and dentate gyrus areas of the hippocampus had increased in male offspring according to the increase in the ginger extract dose. Conclusions: It seems as though ginger extract, which contains compounds such as gingerols, shogaols, and zingerone, can affect memory ability in rats through these compounds' antioxidant properties by affecting embryonic acetylcholine content and place cells.

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Inhibitory effects of [6]-gingerol, a major pungent principle of ginger, on phorbol ester-induced inflammation, epidermal ornithine decarboxylase activity and skin tumor promotion in ICR mice

Cited by 232 publications

References 24 publications

Pungent ginger components modulates human cytochrome P450 enzymes in vitro

Pungent ginger components modulates human cytochrome P450 enzymes in vitro

Cytotoxicity, Toxicity, and Anticancer Activity of Zingiber Officinale Roscoe Against Cholangiocarcinoma

Morphological Effects of Hydroalcoholic Zingiber Officinalis Extract in the Murine Hippocampus of Male Rat Offspring

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