Inhibitory Effects of Antithrombin III on Interactions between Blood Cells and Endothelial Cells during Retinal Ischemia–Reperfusion Injury

Nishijima, Kazuaki; Kiryu, Junichi; Tsujikawa, Akitaka; Honjo, Megumi; Nonaka, Atsushi; Yamashiro, Kenji; Kamizuru, Hiroshi; Ieki, Yoshiaki; Tanihara, Hidenobu; Honda, Yoshio; Ogura, Yuichiro

doi:10.1167/iovs.02-0493

Cited by 31 publications

(31 citation statements)

References 47 publications

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“…A relationship between neutrophil accumulation at inflammatory sites and platelets has become apparent in several tissues 8 -11 including other ocular tissues. 12,13 We found that antibody-induced depletion of circulating neutrophils significantly reduced platelet localization in the limbal vessels, and depletion of blood platelets reduced neutrophil accumulation. 6 In the current study, we investigate the contributions of T cells to the healing and inflammatory events after corneal epithelial abrasion.…”

mentioning

confidence: 77%

γδ T Cells Are Necessary for Platelet and Neutrophil Accumulation in Limbal Vessels and Efficient Epithelial Repair after Corneal Abrasion

Burns

Rumbaut

et al. 2007

The American Journal of Pathology

115

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Corneal epithelial abrasion in C57BL/6 mice induces an inflammatory response with peak accumulation of neutrophils in the corneal stroma within 12 hours. Platelets localize in the limbal vessels throughout the same time course as neutrophils and contribute to wound healing because antibody-dependent depletion of platelets retards epithelial division and wound closure. In the present study, T cells in the limbal epithelium were found to predominantly express the ␥␦ T-cell receptor (TCR). Corneal abrasion in wildtype, CD11a؊/؊ , and P-sel

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mentioning

confidence: 77%

γδ T Cells Are Necessary for Platelet and Neutrophil Accumulation in Limbal Vessels and Efficient Epithelial Repair after Corneal Abrasion

Burns

Rumbaut

et al. 2007

The American Journal of Pathology

115

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“…Therefore, it is possible that the number of IRIs could be reduced if production of these factors could be suppressed. Corticosteroids inhibit the production of various inflammatory molecules [17][18][19] that promote leukocyte adhesion and breakdown of the blood-retinal barrier [20,21] . In addition, Fan et al [22] reported that the mean number of doses was significantly higher with IRI alone than with IRI plus intravitreal triamcinolone acetonide.…”

Section: Discussionmentioning

confidence: 99%

Cytokines and Recurrence of Macular Edema after Intravitreal Ranibizumab in Patients with Branch Retinal Vein Occlusion

et al. 2016

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The aqueous humor levels of cytokines and growth/inflammatory factors were measured in 46 branch retinal vein occlusion (BRVO) patients with macular edema (ME) who were treated with intravitreal ranibizumab injection (IRI). Patients with recurrence of ME received further IRI as needed. The number of IRIs was significantly correlated with age, baseline best-corrected visual acuity, and baseline central macular thickness (CMT), as well as the baseline aqueous levels of 5 cytokines/factors (soluble vascular endothelial growth factor receptor-1, platelet-derived growth factor-AA [PDGF-AA], soluble intercellular adhesion molecule-1, interleukin-6 [IL-6], and IL-8). Multivariate linear regression analysis with stepwise selection confirmed that age, baseline CMT, and baseline PDGF-AA level were independent determinants of the number of IRIs. These findings suggest that inflammatory factors may influence the recurrence of ME in BRVO patients, and that PDGF-AA might be a useful indicator of the number of IRIs required to control ME.

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“…On the basis of the results of these experiments, many investigators have studied various agents that can attenuate tissue damage by suppressing leukocyte-endothelial interactions in the postischemic retina. Antithrombin III [83,84], tacrolimus (FK506) [85], argatroban (direct thrombin inhibitor) [86], statin [87,88], Rho-associated protein kinase inhibitor [89], superoxide dismutase [90], thalidomide [91], selectin ligands/inhibitor (SKK-60060) [92], triamcinolone acetonide [93], ischemic preconditioning [94,95], platelet depression [81], and 17β-estradiol [96] are reported to reduce leukocyte accumulation in the postischemic retina and thereby reduce neural damage.…”

Section: Leukocyte-endothelial Interactions In Pathological Conditionsmentioning

confidence: 99%

Evaluation of Leukocyte-Endothelial Interactions in Retinal Diseases

Tsujikawa

Ogura

2011

Ophthalmologica

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Purpose: We reviewed various methodologies for studying leukocyte-retinal endothelial interactions in vivo, and summarized the information obtained from studies employing these methods. Procedures: Fluorescence dye-enhanced scanning laser ophthalmoscopy facilitates study of leukocyte-cell interactions in the retinal microcirculation. Results: Various methods such as adaptive optics scanning laser ophthalmoscopy (AO-SLO), acridine orange digital angiography, and intravital microscopy provided evidence of the mechanisms of leukocyte recruitment in the retina and of their importance in the pathogenesis of various retinal diseases. Conclusions: Leukocyte behavior can be easily examined in the retina in vivo because the optical media is transparent. SLO substantially contributes to visualizing leukocyte-endothelial interactions in retinal vessels, although most of the methods employing SLO could only be used for animal studies. AO-SLO noninvasively demonstrates the movement of each leukocyte in the parafoveal capillaries in humans. Message: AO-SLO could be useful in investigating the leukocyte-retinal endothelial interactions in various diseases in humans.

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Inhibitory Effects of Antithrombin III on Interactions between Blood Cells and Endothelial Cells during Retinal Ischemia–Reperfusion Injury

Abstract: This study demonstrates the inhibitory effects of AT III on leukocyte and platelet recruitment to the postischemic retina, which may account for the neuroprotective properties of this alpha-2 globulin against retinal ischemia-reperfusion injury.

Cited by 31 publications

References 47 publications

γδ T Cells Are Necessary for Platelet and Neutrophil Accumulation in Limbal Vessels and Efficient Epithelial Repair after Corneal Abrasion

γδ T Cells Are Necessary for Platelet and Neutrophil Accumulation in Limbal Vessels and Efficient Epithelial Repair after Corneal Abrasion

Cytokines and Recurrence of Macular Edema after Intravitreal Ranibizumab in Patients with Branch Retinal Vein Occlusion

Evaluation of Leukocyte-Endothelial Interactions in Retinal Diseases

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