Inhibitory Effects of Bakuchiol, Bavachin, and Isobavachalcone Isolated from<i>Piper longum</i>on Melanin Production in B16 Mouse Melanoma Cells

Ohno, Osamu; Watabe, Taeko; Nakamura, Kazuhiko; Kawagoshi, Masaru; Uotsu, Nobuo; Chiba, Tomohiro; Yamada, Masayoshi; Yamaguchi, Kohji; Yamada, Kaoru; Miyamoto, Kenji; Uemura, Daisuke

doi:10.1271/bbb.100221

Cited by 59 publications

(34 citation statements)

References 24 publications

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“…). Bakuchiol is a purified meroterpene phenol found mainly in the seeds of the Indian plant Psoralea corylifolia (babchi), but it is also found in other plant sources including Psoralea glandulosa , Pimelea drupaceae (cherry riceflower), Ulmus davidiana (Father David elm), Otholobium pubescens and Piper longum (long pepper) . The compound has been found to have antiproliferative, anti‐inflammatory, antioxidant and antiacne activity…”

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confidence: 99%

Prospective, randomized, double‐blind assessment of topical bakuchiol and retinol for facial photoageing

et al. 2018

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Prospective, randomized, double‐blind assessment of topical bakuchiol and retinol for facial photoageing

et al. 2018

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“…5,18,19) Dong et al 20) have reported that bavachin, a phytoestrogen purified from natural herbal plants such as Psoraleae corylifoliae 21) and Piper longum, 22) has estrogen-like activity in estrogen-receptor-positive human breast adenocarcinoma MCF-7/BOS cells. Therefore, we hypothesized that bavachin may have chondroprotective effects as a result of anabolic or anti-catabolic activity in articular cartilage.…”

Section: Discussionmentioning

confidence: 99%

Biological Effects of the Herbal Plant-Derived Phytoestrogen Bavachin in Primary Rat Chondrocytes

Lee

Cho

Kang

et al. 2015

Biological & Pharmaceutical Bulletin

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The aim of this study was to examine the anabolic and anticatabolic functions of bavachin in primary rat chondrocytes. With bavachin treatment, chondrocytes survived for 21 d without cell proliferation, and the proteoglycan content and extracellular matrix increased. Short-term monolayer culture of chondrocytes showed that gene induction of both aggrecan and collagen type II, major extracellular matrix components, was significantly upregulated by bavachin. The expression and activities of cartilage-degrading enzymes such as matrix metalloproteinases and a disintegrin and metalloproteinase with thrombospondin motifs were inhibited significantly by bavachin, while tissue inhibitors of metalloprotease were significantly upregulated. Bavachin inhibits the expression of inducible nitric oxide synthase, a representative catabolic factor, and downregulated the expression of nitric oxide, cyclooxygenase-2, and prostaglandin E 2 in a dose-dependent manner in chondrocytes. Our results suggest that the bavachin has anabolic and potent anticatabolic biological effects on chondrocytes, which may have considerable promise in treating articular cartilage degeneration in the future.Key words Osteoarthritis (OA); articular cartilage; chondrocyte; phytoestrogen; bavachin Osteoarthritis (OA) is a representative degenerative disease associated with aging and is the most common type of arthritis.1) The clinical symptoms of OA are defined as chronic joint pain, stiffness, and loss of mechanical joint function caused by progressive cartilage degeneration.2) Moreover, the prevalence of OA is largely age-dependent and is increased significantly in people over age 65.1) Although the prevalence of OA is less in those under 40, prevalence is increasing in these populations because of obesity, individual heredity, mechanical injuries, and surgical trauma of joints.1) The socioeconomic burden associated with OA is increased by both direct medical expenses and indirect costs caused by decreased productivity in the workplace.2) Although various studies on the pathophysiological etiologies of OA are ongoing, many of the factors causing this disease are still unknown. Hence, clinical treatments of OA have been mainly focused on relieving chronic joint pain by suppressing inflammation in the degenerative joint more so than on cartilage regeneration.Homeostasis of articular cartilage is precisely regulated by the balance between synthesis (anabolism) and degradation (catabolism) of the extracellular matrix (ECM), which is mainly composed of collagen Type II and proteoglycan synthesized from chondrocytes to maintain mechanical function in response to a compressive overload on joints.3) However, perturbations in chondrocytes with normal metabolic properties induce the progressive destruction of ECM through the up-regulation of cartilage-degrading enzymes such as matrix metalloproteinase (MMP)-13, MMP-3, MMP-1, a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS)-4 and ADAMTS-5.3) Recent research has focused on cartilage regenerati...

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“…With the exception of Coccoloba uvifera, inhibitory effects on melanocyte α-MSH production have not been demonstrated for other polygonaceous plants or stilbene compounds [20,21,37]. However, medicinal plants from other botanical families have been shown to inhibit melanin biosynthesis via inhibition of α-MSH production in melanocytes [38-40]. …”

Section: Discussionmentioning

confidence: 99%

Photoprotective and antioxidant effects of Rhubarb: inhibitory action on tyrosinase and tyrosine kinase activities and TNF-α, IL-1α and α-MSH production in human melanocytes

Silveira

Seito

Eberlin

et al. 2013

BMC Complement Altern Med

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BackgroundExposure to ultraviolet (UV) radiation causes various forms of acute and chronic skin damage, including immunosuppression, inflammation, premature aging and photodamage. Furthermore, it induces the generation of reactive oxygen species, produces proinflammatory cytokines and melanocyte-stimulating hormone (MSH) and increases tyrosinase activity. The aim of this study was to evaluate the potential photoprotective effects of Rheum rhaponticum L. rhizome extract on human UV-stimulated melanocytes.MethodsThe effects of Rheum rhaponticum rhizome extract on tyrosine kinase activity, and on interleukin-1α (IL-1α), tumour necrosis factor α (TNF-α), and α-MSH production in human epidermal melanocytes were evaluated under UV-stimulated and non-stimulated conditions. Antioxidant activity was evaluated by lipid peroxidation and 1,1-dyphenyl-2-picryl-hydrazyl (DPPH) assays, while anti-tyrosinase activity was evaluated by the mushroom tyrosinase method.ResultsRheum rhaponticum L. rhizome extract showed in vitro antioxidant properties against lipid peroxidation, free radical scavenging and anti-tyrosinase activities, and inhibited the production of IL-1α, TNF-α, α-MSH, and tyrosine kinase activity in melanocytes subjected to UV radiation.ConclusionsThese results support the inclusion of Rheum rhaponticum L. rhizome extract into cosmetic, sunscreen and skin care products for the prevention or reduction of photodamage.

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Inhibitory Effects of Bakuchiol, Bavachin, and Isobavachalcone Isolated fromPiper longumon Melanin Production in B16 Mouse Melanoma Cells

Cited by 59 publications

References 24 publications

Prospective, randomized, double‐blind assessment of topical bakuchiol and retinol for facial photoageing

Prospective, randomized, double‐blind assessment of topical bakuchiol and retinol for facial photoageing

Biological Effects of the Herbal Plant-Derived Phytoestrogen Bavachin in Primary Rat Chondrocytes

Photoprotective and antioxidant effects of Rhubarb: inhibitory action on tyrosinase and tyrosine kinase activities and TNF-α, IL-1α and α-MSH production in human melanocytes

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