Prospective, randomized, double‐blind assessment of topical bakuchiol and retinol for facial photoageing

Dhaliwal, Sandeep; Rybak, Iryna; Ellis, Samantha R.; Notay, Manisha; Trivedi, Megha; Burney, Waqas; Vaughn, Alexandra R.; Nguyen, Mimi; Reiter, Paloma N.; Bosanac, Suzana S.; Yan, Hongxiang; Foolad, Negar; Sivamani, Raja K

doi:10.1111/bjd.16918

Cited by 87 publications

(106 citation statements)

References 45 publications

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“…This year, Dhaliwal et al reported a study testing a bakuchiol cream twice daily vs a retinol cream daily. Both significantly decreased wrinkle surface area and hyperpigmentation to a similar extent, but the retinol group users reported more skin scaling and stinging.…”

Section: Discussionmentioning

confidence: 99%

“…Bakuchiol, an extract of Psoralea corylifolia seeds, has been found to have similar efficacy to retinol, stimulating collagen in mature fibroblasts and upregulating genes involved in preserving the ECM and dermo‐epidermal junction, and decreasing wrinkles and hyperpigmentation in vivo, without the irritant side effects typical of retinol …”

Section: Introductionmentioning

confidence: 99%

“…6 Bakuchiol, an extract of Psoralea corylifolia seeds, has been found to have similar efficacy to retinol, stimulating collagen in mature fibroblasts and upregulating genes involved in preserving the ECM and dermo-epidermal junction, 7 and decreasing wrinkles and hyperpigmentation in vivo, without the irritant side effects typical of retinol. 8 Ascorbyl tetraisopalmitate is a lipid-soluble vitamin C derivative with broader pH stability than ascorbic acid, 9 that is converted to ascorbic acid in the skin, where it provides an array of antioxidant actions. 10 We report the results with this NFS from five clinical studies on anti-aging efficacy and tolerability, hydration kinetics, transepidermal water loss, efficacy in oily skin, and comedogenesis.…”

mentioning

confidence: 99%

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Clinical evidence of the efficacy and safety of a new 3‐in‐1 anti‐aging topical night serum‐in‐oil containing melatonin, bakuchiol, and ascorbyl tetraisopalmitate: 103 females treated from 28 to 84 days

Goldberg¹,

Robinson

Granger

2019

J of Cosmetic Dermatology

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Summary Background Topical melatonin is a potent antioxidant, yet there have been few clinical studies on its anti‐aging effects on the skin. Objectives To clinically assess the anti‐aging efficacy and safety of a new 3‐in‐1 night facial serum (NFS) combining melatonin with bakuchiol, a novel retinol‐like ingredient, and ascorbyl tetraisopalmitate, in all skin types. Methods Five clinical studies were performed, with a total of 103 subjects treated from 28 to 84 days. Under dermatologist supervision, a 3‐month efficacy and safety study evaluated anti‐aging properties by clinical scoring and instrumental evaluations. Two studies evaluated skin hydration properties for 12 hours after a single application of NFS. Two studies were performed in oily skin: a 1‐month efficacy and safety study and a 1‐month comedogenesis study. Results After 12 weeks, clinical evaluation showed a statistically significant decrease in wrinkles (11%), an increase in skin firmness (8%), a reduction in redness (70%; P < 0.01 for all), and an overall improvement in skin quality and complexion. The reduction in wrinkles and the increase in skin firmness were also supported by instrumental evaluations (Dermatop and Dynaskin). Hydration levels increased significantly from 30 minutes until 12 hours and transepidermal water loss significantly decreased after 4H and 6H. Subjects favorably evaluated the efficacy and cosmetic properties of the serum, and it was well tolerated in all skin types including oily skin. Conclusions This 3‐in‐1 NFS showed significant clinical anti‐aging effects when applied once daily and was well tolerated.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

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Clinical evidence of the efficacy and safety of a new 3‐in‐1 anti‐aging topical night serum‐in‐oil containing melatonin, bakuchiol, and ascorbyl tetraisopalmitate: 103 females treated from 28 to 84 days

Goldberg¹,

Robinson

Granger

2019

J of Cosmetic Dermatology

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“…17015‐60‐0) is a purified meroterpene phenol, and is found mainly in Psoralea corylifolia (babchi seeds), as well as in some other Asian plants, for example, Psoralea glandulosa , Pimelea drupaceae (cherry riceflower), and Ulmus davidiana (Father David elm) . In in vitro and experimental models, bakuchiol has shown various biological properties, including anticancer, antioxidant, oestrogen‐like, antimicrobial, antifungal, liver‐protective, antidiabetic and immune‐suppressive activity . This compound has been found to reduce photoageing and to have antiacne activity, similarly to retinoids .…”

Section: Disccusionmentioning

confidence: 99%

Bakuchiol—A new allergen in cosmetics

et al. 2019

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A 33-year-old female patient presented to our clinic with a 1-year history of erythematous and itchy plaques on the both eyelids, the perioral area, and the neck (Figure 1). She associated her symptoms with food, spices and coffee, but not with cosmetics, as she stated that she used only "hypoallergenic cosmetic products for sensitive skin". She has no other health problems or atopy. Prick tests with inhalant allergens and food gave negative results. Patch tests were performed with the European baseline series and a cosmetic series (Chemotechnique Diagnostics, Vellinge, Sweden), as well as with her creams (all "as is") Noreva Global Exfoliac 6 and Noreva Recovery Cream, and "semi-open" with Noreva Exfoliac Gel, Noreva Actipur Wash (all by Noreva Laboratoires, Paris, France), and ODA Wash (ODA, Elektrėnai, Lithuania). We performed patch tests by the use of Finn Chambers (SmartPractice Europe, Barsbüttel, Germany) covered with Mefix (Mölnlycke Healthcare, Göteborg, Sweden), and read them according to ICDRG guidelines on day (D) 2, D3, and D7. Positive reactions to Noreva Exfoliac Global 6 cream (+++), drometrizole, propyl gallate, dodecyl gallate, 3-(dimethylamino)-1-propylamine (all + reactions) were detected. All positive reactions were considered to be not clinically relevant to the present dermatitis, with the exception of Noreva Exfoliac Global 6 cream. The Noreva Laboratoires representative was contacted, and ingredients were kindly provided and patch tested. Tests were read on D3 and D7. A +++ positive reaction to bakuchiol 0.1% pet. appeared at D3. Ten controls were 398 MALINAUSKIENE ET AL.

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“…A 3‐in‐1 night facial serum (NFS) was developed, containing melatonin, bakuchiol, and ascorbyl tetraisopalmitate, based on the key targets of oxidative stress, inflammation, collagen stimulation, and pigmentation regulation.…”

Section: Introductionmentioning

confidence: 99%

Efficacy and safety of a 3‐in‐1 antiaging night facial serum containing melatonin, bakuchiol, and ascorbyl tetraisopalmitate through clinical and histological analysis

Goldberg

Mraz‐Robinson

Granger

2020

J of Cosmetic Dermatology

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Background Changes induced by intrinsic and extrinsic photoaging result in signs of skin aging including altered pigmentation and wrinkles. A 3‐in‐1 night facial serum (NFS) was developed to treat skin aging by antioxidative and retinoid‐like mechanisms. Objective To determine the clinical and histological effects of the 3‐in‐1 NFS on signs of skin aging, clinically and histologically. Methods & Materials Twenty‐four subjects applied serum nightly for 12 weeks, and 12 subjects continued an extension study to 24 weeks. Clinical assessment of skin quality was performed by dermatologists. Skin biopsy was performed at 12 weeks to assess histological changes. Results There was a global aesthetic improvement over the duration of the study: +1.21 points at 12 weeks; +1.25 at 24 weeks. Skin texture, pigmentation, erythema, skin tone, complexion, lines, and wrinkles all significantly improved (P < .05). There was also a significant reduction in photodamage, hyperpigmentation, and wrinkle scores, most notably horizontal forehead expression lines, and marionette lines (P < .05 for all). Dermal and epidermal thickness increased without reaching statistical significance. Conclusion The 3‐in‐1 NFS had clinically and statistically significant effects on signs of skin aging after 12 weeks, which became more pronounced after 24 weeks.

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Prospective, randomized, double‐blind assessment of topical bakuchiol and retinol for facial photoageing

Abstract: Our study demonstrates that bakuchiol is comparable with retinol in its ability to improve photoageing and is better tolerated than retinol. Bakuchiol is promising as a more tolerable alternative to retinol.

Cited by 87 publications

References 45 publications

Clinical evidence of the efficacy and safety of a new 3‐in‐1 anti‐aging topical night serum‐in‐oil containing melatonin, bakuchiol, and ascorbyl tetraisopalmitate: 103 females treated from 28 to 84 days

Clinical evidence of the efficacy and safety of a new 3‐in‐1 anti‐aging topical night serum‐in‐oil containing melatonin, bakuchiol, and ascorbyl tetraisopalmitate: 103 females treated from 28 to 84 days

Bakuchiol—A new allergen in cosmetics

Efficacy and safety of a 3‐in‐1 antiaging night facial serum containing melatonin, bakuchiol, and ascorbyl tetraisopalmitate through clinical and histological analysis

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