Inhibitory effects of blue honeysuckle (Lonicera caerulea L) on adjuvant-induced arthritis in rats: Crosstalk of anti-inflammatory and antioxidant effects

Wu, Shusong; He, Xi; Wu, Xiaosong; Qin, Si; He, Jianhua; Zhang, Shirui; Hou, De‐Xing

doi:10.1016/j.jff.2015.06.007

Cited by 54 publications

(42 citation statements)

References 34 publications

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“…Some reports from both in vivo animal studies and in vitro cell line investigations showed that haskap berries may protect from inflammation and oxidation triggered diseases (Rupasinghe et al, 2015). Blue honeysuckle extract in rat model attenuated adjuvant-induced arthritis symptoms with crosstalk of anti-inflammatory and antioxidant effects (Wu et al, 2015). The application of L. caerulea berry extract protected liver against the damage caused by lipopolysaccharide which shows their potential in prevention of hepatitis (Wang et al, 2016a).…”

Section: Introductionmentioning

confidence: 99%

“…The most common anthocyanidins are petunidin, cyanidin, pelargonidin, delphinidin, malvidin and peonidin appearing in plants bound to glucose, galactose, arabinose, rhamnose or xylose. Due to its high content of cyanidin-3-glucoside the haskap berries might have antioxidant, anti-inflammatory, antimicrobial, cardioprotective and hepatoprotective activities (Lila et al, 2016;Myjavcová et al, 2010;Wu et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

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Bioactive compounds and antioxidant capacity of Lonicera caerulea berries: Comparison of seven cultivars over three harvesting years

Auzanneau

Weber

Kosińska-Cagnazzo

et al. 2018

Journal of Food Composition and Analysis

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This study aimed at characterization of bioactive compounds of haskap berries (Lonicera caerulea L.) cultivated in Switzerland and their antioxidant capacity. Seven cultivars i.e. 'Berry Smart Blue', 'Indigo Gem', 'Indigo Treat', 'Morena', 'Tundra', 'Uspiech' and 'Viola' were compared over three harvesting years. Cyanidin-3-glucoside was the main anthocyanin found in haskap berries and at the same time the predominant phenolic compound identified, its content varied between 12.5 and 87.5 mg/g of dry matter. 'Morena', 'Indigo Treat' and 'Uspiech' cultivars emerged as rich in total polyphenols, total anthocyanins and antioxidant capacity. The content of individual polyphenols was the highest in 'Indigo Treat' berries. Ascorbic acid content was in the range of 1.78-4.21 mg/g DM. It was the highest in 'Indigo Gem' and 'Indigo Treat' cultivars. Sugars were more concentrated in 'Indigo Gem', 'Indigo Treat' and 'Viola'. The significant differences in bioactive content between different harvesting years evoked by different weather conditions were noted. 'Indigo Treat' cultivar deserves further attention as potentially well adapted for further cultivation in Switzerland and providing berries rich in bioactive compounds, which might be of interest to the consumers concerned about health promoting properties of their diet.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Bioactive compounds and antioxidant capacity of Lonicera caerulea berries: Comparison of seven cultivars over three harvesting years

Auzanneau

Weber

Kosińska-Cagnazzo

et al. 2018

Journal of Food Composition and Analysis

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“…Some reports suggest that haskap flowers can tolerate temperatures as low as −8°C and whole plants as low as −40°C (Hummer et al 2012;Ochmian et al 2012). The nutritional value and potential health benefits of consuming haskap fruit have been well documented (Palíková et al 2009;Rupasinghe et al 2012;Wu et al 2015;Caprioli et al 2016) and are the subject of a critical review by Celli et al (2014). Haskap fruit are rich in a variety of bioactive compounds, particularly phenolics, anthocyanins, and vitamin C (Wojdyło et al 2013;Zhao et al 2015).…”

Section: Introductionmentioning

confidence: 99%

Performance of five haskap (Lonicera caerulea L.) cultivars and the effect of hexanal on postharvest quality

et al. 2018

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Growers are challenged to provide premium, ripe haskap fruit to market while limiting the negative attributes associated with over-ripening. Hexanal is an inhibitor of phospholipase D, an enzyme involved in membrane degradation, and has shown promise in extending the longevity of fruit. This study investigated the performance of a hexanal-based preharvest spray for enhancing the quality and shelf life of haskap fruit, an emerging crop in Canada. At two locations in 2015, 2016, and 2017, five cultivars were sprayed with a control treatment or a 0.02% hexanal formulation at 2-3 wk before harvest. Fruit was stored at 4°C and assessed for quality at successive times. Although inconsistent, results suggest a hexanal spray may impart a small benefit to the postharvest quality of haskap fruit. Secondary objectives included describing important agronomic characteristics of haskap and assessing the potential of a hexanal preharvest spray for enhancing fruit retention. Hexanal did not reduce fruit drop and had no effect on quality at harvest. Fruit contained high levels of soluble solids and titratable acids, were very dark in colour, and did not degrade in quality as rapidly as softer fruit crops such as strawberry or raspberry.

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“…Haskap berry has a higher antioxidant capacity than other common fruits [ 14 , 15 ]. Recent studies have demonstrated anti-inflammatory [ 16 , 17 ], antiarthritis [ 18 ], antiobesity [ 19 ], and antidiabetic [ 20 ] properties of haskap berry. We have demonstrated that C3G-rich haskap berry extract can reduce NNK acetate-induced DNA double-strand breaks and oxidative stress in healthy human bronchial epithelial (BEAS-2B) cells in vitro [ 21 ].…”

Section: Introductionmentioning

confidence: 99%

Cyanidin-3-O-Glucoside-Rich Haskap Berry Administration Suppresses Carcinogen-Induced Lung Tumorigenesis in A/JCr Mice

Amararathna

Rupasinghe

2020

Molecules

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In our previous study, we demonstrated that cyanidin-3-O-glucoside (C3G)-rich haskap (Lonicera caerulea L.) berry extracts can attenuate the carcinogen-induced DNA damage in normal lung epithelial cells in vitro. Here, the efficacy of lyophilized powder of whole haskap berry (C3G-HB) in lowering tobacco-specific nitrosamine, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone, (NNK)-induced lung tumorigenesis in A/JCr mice was investigated. Three weeks after daily oral administration of C3G-HB (6 mg of C3G in 0.2 g of C3G-HB/mouse/day), lung tumors were initiated by a single intraperitoneal injection of NNK. Dietary C3G-HB supplementation was continued, and 22 weeks later, mice were euthanized. Lung tumors were visualized through positron emission tomography (PET) and magnetic resonance imaging (MRI) 19 weeks after NNK injection. Dietary supplementation of C3G-HB significantly reduced the NNK-induced lung tumor multiplicity and tumor area but did not affect tumor incidence. Immunohistochemical analysis showed reduced expression of proliferative cell nuclear antigen (PCNA) and Ki-67 in lung tissues. Therefore, C3G-HB has the potential to reduce the lung tumorigenesis, and to be used as a source for developing dietary supplements or nutraceuticals for reducing the risk of lung cancer among high-risk populations.

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Inhibitory effects of blue honeysuckle (Lonicera caerulea L) on adjuvant-induced arthritis in rats: Crosstalk of anti-inflammatory and antioxidant effects

Cited by 54 publications

References 34 publications

Bioactive compounds and antioxidant capacity of Lonicera caerulea berries: Comparison of seven cultivars over three harvesting years

Bioactive compounds and antioxidant capacity of Lonicera caerulea berries: Comparison of seven cultivars over three harvesting years

Performance of five haskap (Lonicera caerulea L.) cultivars and the effect of hexanal on postharvest quality

Cyanidin-3-O-Glucoside-Rich Haskap Berry Administration Suppresses Carcinogen-Induced Lung Tumorigenesis in A/JCr Mice

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