Inhibitory effects of Caesalpinia sappan on growth and invasion of methicillin-resistant Staphylococcus aureus

Kim, Kang-Ju; Yu, Hyeon-Hee; Jeong, Seung-Il; Cha, Jung-Dan; Kim, Shin-Moo; You, Yingjian

doi:10.1016/j.jep.2003.11.017

Cited by 38 publications

(23 citation statements)

References 19 publications

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“…This type of combination approach may offer new strategies for treatment of infections with bacteria such as Staphylococcus aureus and A. baumannii as their multi-class resistance is growing. An example of this approach can be demonstrated by an in vitro study wherein caesalpinia sappan markedly decreased the MICs of ampicillin and oxacillin against MRSA (Kim et al, 2004). If such a synergistic combination clears the infection more efficiently, the length of treatment may be shortened and associated antibiotic toxicities may be reduced.…”

Section: Discussionmentioning

confidence: 99%

Screening of herbal extracts against multi‐drug resistant Acinetobacter baumannii

Miyasaki

Nichols

Morgan

et al. 2010

Phytotherapy Research

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Antibiotic resistance is increasing resulting in a decreasing number of fully active antimicrobial agents available to treat infections with multi-drug resistant (MDR) bacteria. Herbal medicines may offer alternative treatment options. A direct inoculation method simulating the standard disc diffusion assay was developed to determine in vitro antimicrobial activity of sixty herbal extracts against MDR-Acinetobacter baumannii (A. baumannii). Eighteen herbal extracts inhibited MDR-A. baumannii on agar plates, although the magnitude and quality of bacterial inhibition differed considerably among the antibacterial herbal extracts. Next, minimal inhibitory concentration (MIC) of these antibacterial herbal extracts was calculated using a broth microdilution assay. For most herbal extracts, the larger the zone of inhibition on agar plates, the lower the MIC. In general, hetero-resistance on agar plates correlated with higher MIC. The skip well phenomenon was seen with two herbal extracts. In conclusion, 30% of the screened herbal extracts demonstrated in vitro antibacterial activity against MDR-A. baumannii using similar rigorous testing methods as those commonly employed for assessing antimicrobial activity of synthetic antibacterial agents. Characterization of a specific compound conferring this antibacterial activity of the herbal extracts may help to identify novel antimicrobial agents active against highly resistant bacteria.

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Section: Discussionmentioning

confidence: 99%

Screening of herbal extracts against multi‐drug resistant Acinetobacter baumannii

Miyasaki

Nichols

Morgan

et al. 2010

Phytotherapy Research

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“…Antioxidant DPPH radical scavenging assay Sasaki et al; [15] Batubara et al [14] Ferric reduction assay Sasaki et al [15] Linoleic acid peroxidation assay Sasaki et al [15] Antibacterial Zone of inhibition Kim et al; [33] Srinivasan et al [32] MIC/MBC Xu and Lee; [5] Batubara et al; [14] Nirmal & Panichayupakaranant [13] Anti-inflammatory LPS-induced NO production Sasaki et al; [15] Hu et al; [39] Washiyama et al; [6] Wu et al [40] Inhibition of iNOS gene expression Sasaki et al; [15] Hu et al; [39] Washiyama et al; [6] Bae et al [3] Hemeoxygenase-1 expression Hu et al; [39] Choi et al [50] Bilirubin production Hu et al [39] Prostaglandin E 2 production Hu et al; [39] Wang et al [22] Tumor necrosis factor-a production Hu et al; [39] Wu et al; [40] Wang et al [22] Interlukin (IL)-1b production Hu et al; [39] Wu et al; [40] Wang et al [22] Nucler factor (NF-k B) expression Bae et al; [3] Wang et al; [22] Toegel et al; [1] Lee et al [7] Activator protein-1 expression Bae et al [3] …”

Section: Pharmacological Activities Methods/model System Referencesmentioning

confidence: 99%

“…The maximum zone of inhibition was observed in ethanolic extract against Pseudomonas aeruginosa (34 mm) followed by Staphylococcus aureus (31 mm), Salmonella typhi (24 mm), Enterobacter aerogens (21 mm), Candida albicans (20 mm), Escherichia coli (15 mm) and minimum zone of inhibition was observed against Aspergillus niger (14 mm) [32]. Methanol extract of CS heartwood extract showed higher inhibitory activity against methicillin sensitive Staphylococcus aureus (MSSA) as well as methicillin resistant Staphylococcus aureus (MRSA) (14 mm) than n-butanol, chloroform and aqueous extracts (8 mm) [33] . Flavonoids in the methanolic extracts of CS could be related with the antibacterial activity against MRSA.…”

Section: Antibacterial Activitymentioning

confidence: 99%

Brazilin from Caesalpinia sappan heartwood and its pharmacological activities: A review

Nirmal

Rajput

Prasad³

et al. 2015

Asian Pacific Journal of Tropical Medicine

231

153

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Caesalpinia sappan L. (CS) is a plant of Leguminosae family, commonly known as Brazil or Sappan wood. CS is distributed in Southeast Asia and its dried heartwood has been used as traditional ingredient of food or beverages and has a wide variety of medicinal properties. Higher extraction yield of CS wood was achieved with 95% ethanol for 2 h. Chemical constituent's investigation of sappan wood resulted in the isolation of various structural types of phenolic components including one xanthone, one coumarin, three chalcones, two flavones three homoisoflavonoids and brazilin. Brazilin [(6a S-cis)-7, 11b-dihydrobenz[b]indeno[1,2-d]pyran-3,6a,9,10(6H)- tetrol], a major and active compound found in CS heartwood. Most of the folkloric uses of brazilin were validated by the scientific studies such as antioxidant, antibacterial, anti-inflammatory, anti-photoaging, hypoglycemic, vasorelaxant, hepatoprotective and anti-acne activity. CS heartwood extract is safe and did not produce any acute or subacute toxicity in both male and female rats. Brazilin is the safe natural compound having potential to develop as a medicinal compound with application in food, beverage, cosmetics and pharmaceutical industries to screen its clinical use in modern medicine. The information gained could provide the important and potential approach for pharmaceutical researcher to implicate the knowledge of brazilin in the formulation of new drug and to reveal therapeutic and gaps requiring future research opportunities. More studies are needed to evaluate the potential application of brazilin as preservative and coloring agent in food processing industries.

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“…Staphylococcus aureus is one of the most important pathogens that cause suppuration, abscess formation, a variety of pyogenic infections and even fatal septicemia in human beings (Kim et al 2004). Due to the development of methicillin resistance among S. aureus isolates, treatment of this infection has become a problematic one (Vidhani et al 2001).…”

Section: Introductionmentioning

confidence: 99%

Antibacterial activity of some salt marsh halophytes and mangrove plants against methicillin resistant Staphylococcus aureus

Chandrasekaran

Kannathasan

Venkatesalu

et al. 2008

World J Microbiol Biotechnol

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The antibacterial activity of aqueous and methanol extracts of leaves/shoots of five salt marsh halophytes and six mangroves was studied against methicillin resistant, clinical isolates of Staphylococcus aureus. There was a clear comparability between the salt marsh halophytes and mangroves in their antibacterial action. The mangrove plants possessed higher antibacterial potency than the salt marsh halophytes. The highest activity was recorded with the methanol extract of Excoecaria agallocha followed by the methanol extracts of Aegiceras corniculatum, Lumnitzera racemosa and Ceriops decandra. The minimum inhibitory concentration (MIC) values ranged from 0.125 to 4 mg/mL and 1 to 16 mg/mL for methanol and aqueous extracts, respectively. Further separation of active principle from the potent mangrove plant will be useful for the control of drug resistant strains of S. aureus.

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Inhibitory effects of Caesalpinia sappan on growth and invasion of methicillin-resistant Staphylococcus aureus

Cited by 38 publications

References 19 publications

Screening of herbal extracts against multi‐drug resistant Acinetobacter baumannii

Screening of herbal extracts against multi‐drug resistant Acinetobacter baumannii

Brazilin from Caesalpinia sappan heartwood and its pharmacological activities: A review

Antibacterial activity of some salt marsh halophytes and mangrove plants against methicillin resistant Staphylococcus aureus

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