Inhibitory effects of clonidine on bronchospasm induced in guinea-pigs by vagal stimulation or antigen challenge

Andersson, Rolf G. G.; Fügner, A; Lindgren, Björn; Muačević, G.

doi:10.1016/0014-2999(86)90658-8

Cited by 28 publications

(15 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition, adrenaline should reduce the bronchial mucosal oedema via its effect on microvascular permeability. It may also reduce the parasympathetic tonus allowing a greater bronchodilation [7,8,18,19]. A favourable effect of adrenaline on gas exchange could be exptected too.…”

Section: Discussionmentioning

confidence: 97%

“…Nebulized adrenaline offers potential theoretical advantages when compared with a pure I]2 agonist like salbutamol: first it may act more rapidly than 132 agonists; second it may increase bronchial caliber reducing bronchial mucosal oedema through its c~ agonist effects [4]. Additional beneficial effects of adrenaline in acute asthma could be expected from its antagonistic effect on the vagal bronchial tonus by inhibition of airway cholinergic neurotransmission [7,8]. However, these advantages may be hampered, at least theoretically, by a bronchoconstrictor effect due to the ~t agonist properties of adrenaline and the need for more frequent administration of the drug according to its shorter half-life.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

A controlled trial of nebulized salbutamol and adrenaline in acute severe asthma

et al. 1995

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

A controlled trial of nebulized salbutamol and adrenaline in acute severe asthma

et al. 1995

View full text Add to dashboard Cite

show abstract

“…Previous researches have not demonstrated any of the alpha 2 adrenergic receptor in the respiratory epithelial surface (19). Inhibitory effect of the clonidine in bronchoconstriction might be induced with straight bronchodilation, or through inhibition of the vagal reflex, or with the inhibition of the release of histamine as an inhibition caused by an antigen (20). …”

Section: Discussionmentioning

confidence: 99%

Importance of Alpha-adrenergic Receptor Subtypes in Regulating of Airways Tonus at Patients with Bronchial Asthma

et al. 2014

View full text Add to dashboard Cite

Background:In this work, effect of Tamsulosin hydrochloride as antagonist of alpha1A and alpha1B- adrenergic receptor and effect of Salbutamol as agonist of beta2- adrenergic receptor in patients with bronchial asthma and increased bronchial reactibility was studied.Methods:Parameters of the lung function are determined by Body plethysmography. Raw and ITGV were registered and specific resistance (SRaw) was also calculated. Tamsulosin was administered in per os way as a preparation in the form of the capsules with a brand name of “Prolosin”, producer: Niche Generics Limited, Hitchin, Herts.Results:Results gained from this research show that blockage of alpha1A and alpha1B- adrenergic receptor with Tamsulosin hydrochloride (0.4 mg and 0.8 mg in per os way) has not changed significantly (p > 0.1) the bronchomotor tonus of tracheobronchial tree in comparison to the inhalation of Salbutamol as agonist of beta2- adrenergic receptor (2 inh. x 0.2 mg), (p < 0.05). Arterial blood pressure showed no significant decrease following the administration of the dose of 0.8 mg Tamsulosin.Conclusion:This suggests that the activity of alpha1A and alpha1B- adrenergic receptor in the smooth musculature is not a primary mechanism which causes reaction in patients with increased bronchial reactibility, in comparison to agonists of beta2 – adrenergic receptor which emphasizes their significant action in the reduction of specific resistance of airways.

show abstract

“…Previous researches have not demonstrated any of the alpha -2 adrenergic receptor in the respiratory epithelial surface (14). Lately, experiments performed in vivo indicate that clonidine intermediates an inhibitory control over the activity of vagal excitation (15). Inhibitory effect of the clonidine in bronchoconstriction might be induced with direct bronchodilation, or through inhibition of the vagal ref lex, or with the inhibition of the release of histamine, as an inhibition caused by an antigen (16).…”

Section: Discussionmentioning

confidence: 99%

Activity of the Adrenergic Nerve System in the Airways Permeability of Healthy Persons

Gashi

Islami²,

Mustafa³

et al. 2013

Acta Inform Med

View full text Add to dashboard Cite

Objective:In this work, role of the adrenergic nerve system (alpha1 and beta2) in adjustment of the bronchomotor tonus in healthy people was researched.Methods:Parameters of the lung function are determined by Body plethysmography. Raw and ITGV were registered and SRaw was calculated as well. Aerosolization is done with standard aerosolizing machines – Asema.Results:Results gained shows that following the blockade of beta-2 adrenergic receptor with Propranolol (20 mg–aerosol), stimulation of alpha adrenergic receptor with Oxedrine (120 mg-aerosol) and blockage of these receptors with Tolazoline (20 mg-aerosol), does not change significantly the bronchomotor tonus of the tracheobronchial tree (p > 0.1). Meanwhile, stimulation of the beta-2 adrenergic receptor with Hexoprenaline (2 inh × 0.2 mg) is associated with a significant increase of the peripheral resistance of the airways (p < 0.01).Conclusion:This suggests that the activity of the alpha1-adrenergic receptor, unlike the activity of the beta2-adrenergic receptor in the healthy people smooth musculature, is not significant and as such is insufficient to oppose to the tonic activities of the cholinergic system.

show abstract

Inhibitory effects of clonidine on bronchospasm induced in guinea-pigs by vagal stimulation or antigen challenge

Cited by 28 publications

References 9 publications

A controlled trial of nebulized salbutamol and adrenaline in acute severe asthma

A controlled trial of nebulized salbutamol and adrenaline in acute severe asthma

Importance of Alpha-adrenergic Receptor Subtypes in Regulating of Airways Tonus at Patients with Bronchial Asthma

Activity of the Adrenergic Nerve System in the Airways Permeability of Healthy Persons

Contact Info

Product

Resources

About