Inhibitory effects of compounds isolated from
            <i>Dioscorea batatas</i>
            Decne peel on particulate matter-induced pulmonary injury in mice

Lee, Wonhwa; Jeong, Sang Hoon; Gu, Myeong Ju; Lim, Ji Sun; Park, Eui Kyun; Baek, Moon‐Chang; Kim, Jong-Sang; Hahn, Dongyup; Bae, Jong‐Sup

doi:10.1080/15287394.2019.1646174

Cited by 23 publications

(12 citation statements)

References 67 publications

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“…Therefore, inflammatory responses are recognized as the dominant biological response to PM exposure. Recently, we reported PM 2.5 -mediated pulmonary inflammatory responses such as the vascular disruptive responses and the upregulated expressions of inflammatory molecules such as p38, reactive oxygen species (ROS), IL-6, and TNF-α [26][27][28]. The present research demonstrated that BIPM can inhibit both the infiltration of lung tissue by inflammatory cells and inflammatory cytokine production in our mouse model of PM-induced lung injury.…”

Section: Discussionsupporting

confidence: 60%

Biapenem as a Novel Insight into Drug Repositioning against Particulate Matter-Induced Lung Injury

Lee

Baek

Kim

et al. 2020

IJMS

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The screening of biologically active chemical compound libraries can be an efficient way to reposition Food and Drug Adminstration (FDA)-approved drugs or to discover new therapies for human diseases. Particulate matter with an aerodynamic diameter equal to or less than 2.5 μm (PM2.5) is a form of air pollutant that causes significant lung damage when inhaled. This study illustrates drug repositioning with biapenem (BIPM) for the modulation of PM-induced lung injury. Biapenem was used for the treatment of severe infections. Mice were treated with BIPM via tail-vein injection after the intratracheal instillation of PM2.5. Alterations in the lung wet/dry weight, total protein/total cell count and lymphocyte count, inflammatory cytokines in the bronchoalveolar lavage fluid (BALF), vascular permeability, and histology were monitored in the PM2.5-treated mice. BIPM effectively reduced the pathological lung injury, lung wet/dry weight ratio, and hyperpermeability caused by PM2.5. Enhanced myeloperoxidase (MPO) activity by PM2.5 in the pulmonary tissue was inhibited by BIPM. Moreover, increased levels of inflammatory cytokines and total protein by PM2.5 in the BALF were also decreased by BIPM treatment. In addition, BIPM markedly suppressed PM2.5-induced increases in the number of lymphocytes in the BALF. Additionally, the activity of mammalian target of rapamycin (mTOR) was increased by BIPM. Administration of PM2.5 increased the expression levels of toll-like receptor 4 (TLR4), MyD88, and the autophagy-related proteins LC3 II and Beclin 1, which were suppressed by BIPM. In conclusion, these findings indicate that BIPM has a critical anti-inflammatory effect due to its ability to regulate both the TLR4-MyD88 and mTOR-autophagy pathways, and may thus be a potential therapeutic agent against diesel PM2.5-induced pulmonary injury.

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Section: Discussionsupporting

confidence: 60%

Biapenem as a Novel Insight into Drug Repositioning against Particulate Matter-Induced Lung Injury

Lee

Baek

Kim

et al. 2020

IJMS

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“…Phenanthrene Compounds 1 , 2 and 3 (Figure 1) were isolated from the peel of D. batatas following the method suggested by our previous studies [18,19]. The peel was extracted with 95% ethanol for 48 h, and solvents were removed in vacuo.…”

Section: Methodsmentioning

confidence: 99%

“…Compound 3 was isolated from the ninth fraction from LH20 column chromatography by using the same HPLC condition for the isolation of Compounds 1 and 2 . The structures of Compounds 1 and 2 were identified by our previous study [18,19] on the basis of 1 H- and 13 C-NMR spectra (Figures S1 and S2), and the structure of Compound 3 as identified as 6-hydroxy-2,4,7-trimethoxyphenanthrene (batatasin I) through a comparison of 1 H and 13 C NMR spectra (Figure S3) with a previous report [22]. NMR experiments were carried out using a Bruker Ascend ( 1 H-500 MHz, 13 C-125 MHz, Billerica, MA, USA) spectrometer.…”

Section: Methodsmentioning

confidence: 99%

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Quantitative Analysis of Bioactive Phenanthrenes in Dioscorea batatas Decne Peel, a Discarded Biomass from Postharvest Processing

Kim

Lee

et al. 2019

Antioxidants

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Dioscorea batatas Decne (Chinese yam) has been widely cultivated in East Asia for the purposes of food and medicinal uses for centuries. Along with its high nutritional value, the medicinal value of D. batatas has been extensively investigated in association with phytochemicals such as allantoin, flavonoids, saponins and phenanthrenes. Phenanthrenes are especially considered the standard marker chemicals of the Chinese yam for their potent bioactivity and availability of analysis with conventional high performance liquid chromatography with ultraviolet detection (HPLC-UV) methods. In order to investigate how much the contents of phenanthrenes are in the actual food products provided for consumers, D. batatas tuber was peeled and separated into its peel and flesh as in the conventional processing method. A quantitative analysis using the HPLC-UV method revealed that phenanthrenes are concentrically present in the D. batatas peel, while phenanthrenes are present in the flesh under the limit of detection. The difference in the contents of phenanthrenes is estimated to have arisen the considerable difference of antioxidant potential between the peel and the flesh. The results from this study suggest the high value of the discarded biomass of the Chinese yam peel and the necessity for the utilization of the Chinese yam peel.

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“…Dioscorea batatas Decaisne is known to have the lung-nourishing and cough relieving properties ( Kang B, 2000 ; Ma et al, 2018 ; Min-Hye Yang, 2009 ). It has been shown to contain anti-oxidant and anti-inflammatory activities, and inhibit PM 2.5 -induced lung injury, whose pathological phenotypes are similar to ARDS ( Lee, W. et al, 2019a ). Taraxacum officinale (L.) Weber ex F.H.Wigg has traditionally been used to treat respiratory problems, including sore throat and lung abscess ( Hee-Jung Ha, 2011 ; Kang B, 2000 ).…”

Section: Introductionmentioning

confidence: 99%

Botanical formulation, TADIOS, alleviates lipopolysaccharide (LPS)-Induced acute lung injury in mice via modulation of the Nrf2-HO-1 signaling pathway

Lee

et al. 2021

Journal of Ethnopharmacology

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Inhibitory effects of compounds isolated from Dioscorea batatas Decne peel on particulate matter-induced pulmonary injury in mice

Cited by 23 publications

References 67 publications

Biapenem as a Novel Insight into Drug Repositioning against Particulate Matter-Induced Lung Injury

Biapenem as a Novel Insight into Drug Repositioning against Particulate Matter-Induced Lung Injury

Quantitative Analysis of Bioactive Phenanthrenes in Dioscorea batatas Decne Peel, a Discarded Biomass from Postharvest Processing

Botanical formulation, TADIOS, alleviates lipopolysaccharide (LPS)-Induced acute lung injury in mice via modulation of the Nrf2-HO-1 signaling pathway

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