Inhibitory Effects of Cycloheterophyllin on Melanin Synthesis

Shim, Joong-Hyun

doi:10.3390/molecules26092526

Cited by 9 publications

(5 citation statements)

References 20 publications

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“…The UV-mediated melanin synthesis can cause problematic pigmentation in the skin, accelerates skin aging, and can also cause skin cancer [ 32 ]. For this reason, melanin synthesis inhibitors have been studied, but problems regarding skin safety and formulation stability have been encountered [ 33 ]. Consequently, the need for research on safe and efficient melanin synthesis inhibitors has emerged [ 34 ].…”

Section: Discussionmentioning

confidence: 99%

Topical Application of No-Ozone Cold Plasma in Combination with Vitamin C Reduced Skin Redness and Pigmentation of UV-Irradiated Mice

Nam

Choi²,

Kim

2023

Biomedicines

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Ultraviolet (UV) is the main cause of sunburn on the skin as it induces erythema and accelerates pigmentation. Vitamin C is one of the most frequently used compounds to reduce UV-induced skin pigmentation, but it has limitations in absorption through the skin. In this study, we tested whether a no-ozone cold plasma (NCP) treatment can improve UV-irradiated skin by helping the action of Vitamin C. For this, among five groups of HRM-2 hairless mice, four groups of mice were subjected to UVB irradiation, and three groups of UVB-treated mice were treated with NCP, Vitamin C, and NCP + Vitamin C, respectively. For evaluating the effect of each treatment, the melanin and erythema index was measured during animal experiments. Histological changes were monitored by performing H&E and MTS and IHC against tyrosinase and melanin. As a result, the naturally recovered mice showed a 28-point decrease in the melanin index, whereas a decrease of around 88, 74.3, and 106 points was detected in NCP-, Vitamin C-, and NCP + vitamin C-treated mice, respectively. Likewise, only a 39-point reduction in the erythema index was monitored in naturally recovered mice, but the NCP-, vitamin C-, and NCP + vitamin C-treated mice showed a 87.3-, 77-, and 111-point reduction, respectively. Interestingly, the skin tissues of the mice treated with NCP in combination with Vitamin C mostly recovered from UVB-induced damage. Altogether, this study elucidated the beneficial effect of the treatment of NCP in combination with Vitamin C on the UVB-irradiated skin, which might be helpful for treating sunburn on the skin.

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Section: Discussionmentioning

confidence: 99%

Topical Application of No-Ozone Cold Plasma in Combination with Vitamin C Reduced Skin Redness and Pigmentation of UV-Irradiated Mice

Nam

Choi²,

Kim

2023

Biomedicines

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“…Because 10 µM Ech A alone significantly reduced MITF expression, we think that either a low concentration of Ech A could not inhibit α-MSH stimulation or that it was an experimental error. In addition to Ech A, other natural products obtained from marine animals and plants have been investigated as potential skin-whitening agents [40,41]. Chen et al [40] found that 196 mM chitosan from crustaceans inhibited the expression of the MITF, tyrosinase, TYRP1, and TYRP2 proteins and the tyrosinase activity triggered by α-MSH in B16F10 cells, so they suggested chitosan as a potential skin-whitening agent.…”

Section: Discussionmentioning

confidence: 99%

Echinochrome A Inhibits Melanogenesis in B16F10 Cells by Downregulating CREB Signaling

et al. 2022

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Excessive increase in melanin pigment in the skin can be caused by a variety of environmental factors, including UV radiation, and can result in spots, freckles, and skin cancer. Therefore, it is important to develop functional whitening cosmetic reagents that regulate melanogenesis. In this study, we investigated the effects of echinochrome A (Ech A) on melanogenesis in the B16F10 murine melanoma cell line. We triggered B16F10 cells using α-MSH under Ech A treatment to observe melanin synthesis and analyze expression changes in melanogenesis-related enzymes (tyrosinase, tyrosinase-related protein 1 (TYRP1), and tyrosinase-related protein 2 (TYRP2)) at the mRNA and protein levels. Furthermore, we measured expression changes in the microphthalmia-associated transcription factor (MITF), CREB, and pCREB proteins. Melanin synthesis in the cells stimulated by α-MSH was significantly reduced by Ech A. The expression of the tyrosinase, TYRP1, and TYRP2 mRNA and proteins was significantly decreased by Ech A, as was that of the MITF, CREB, and pCREB proteins. These results show that Ech A suppresses melanin synthesis by regulating melanogenesis-related enzymes through the CREB signaling pathway and suggest the potential of Ech A as a functional agent to prevent pigmentation and promote skin whitening.

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“…Thus, compound 8 was established as shown and named vanderbyliolide A. Eight known compounds were identified as (22E, 24R)-6β-methoxyergosta-7, 9(11), 22-triene-3β, 5α-diol (2) [36], 5α,6α-epoxy-3β-hydroxy-(22E)-ergosta-8( 14),22-dien-7-one (3) [37], 3β, 5α, 9α-trihydroxy-(22E, 24R)-ergosta-7, 22-dien-6-one (4) [38], (22E, 24R)-ergost-7, 22-dien-3β, 5α-diol-6-one (5) [39], dankasterone (6) [40], 4-hydroxy-17R-methylincisterol (7) [41], cornilkone C (9) [42], and (1H-indol-3-yl) oxoacetic acid methyl ester (10) [43] by comparing their spectroscopic data with the literature. All compounds were isolated from the species of the genus Vanderbylia for the first time.…”

Section: Structure Elucidationmentioning

confidence: 99%

“…For instance, vitamin C is susceptibly degradable and sensitive to temperature and air [6]. Kojic acid and arbutin are reported to cause safety issues such as skin irritation [7], while arbutin is chemically instable and might result in leukemia due to the metabolized products of benzene analogues [8]. Therefore, safe, stable, and effective tyrosinase inhibitors are still in great need for the treatment of dyspigmentation disease and cosmetic applications.…”

Section: Introductionmentioning

confidence: 99%

Secondary Metabolites from the Cultures of Medicinal Mushroom Vanderbylia robiniophila and Their Tyrosinase Inhibitory Activities

Wang

Jia

Wang

et al. 2023

JoF

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Vanderbylia robiniophila (Huaier in Chinese) has been used as a traditional herbal medicine in China for over 1600 years. However, the secondary metabolites of V. robiniophila have not been systematically examined. Corresponding chemical investigation in this study led to the discovery of two new compounds, (22E, 24R)-6β, 7α-dimethoxyergosta-8(14), 22-diene-3β, 5α-diol (1) and vanderbyliolide A (8), along with eight known ones (2–7, 9–10). Their structures were determined by extensive spectroscopic analyses and electronic circular dichroism (ECD) calculations. The tyrosinase inhibitory activity of all isolated compounds was evaluated, and compound 10 showed a potential tyrosinase inhibitory effect with an IC50 value of 60.47 ± 2.63 μM. Kinetic studies of the inhibition reactions suggested that 10 provides the inhibitory ability on tyrosinase in an uncompetitive way.

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Inhibitory Effects of Cycloheterophyllin on Melanin Synthesis

Cited by 9 publications

References 20 publications

Topical Application of No-Ozone Cold Plasma in Combination with Vitamin C Reduced Skin Redness and Pigmentation of UV-Irradiated Mice

Topical Application of No-Ozone Cold Plasma in Combination with Vitamin C Reduced Skin Redness and Pigmentation of UV-Irradiated Mice

Echinochrome A Inhibits Melanogenesis in B16F10 Cells by Downregulating CREB Signaling

Secondary Metabolites from the Cultures of Medicinal Mushroom Vanderbylia robiniophila and Their Tyrosinase Inhibitory Activities

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