Inhibitory effects of DA-9601 on ethanol-induced gastrohemorrhagic lesions and gastric xanthine oxidase activity in rats

Huh, Keùn; Kwon, Tae Hyup; Shin, Uk Sup; Kim, Won; Ahn, Byoung Ok; Oh, Tae Young; Kim, Jung-Ae

doi:10.1016/s0378-8741(03)00235-6

Cited by 54 publications

(52 citation statements)

References 39 publications

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“…Excess ethanol also generates harmful ROS, superoxide anion, and hydroperoxy free radicals, involved in the pathogenesis of gastric mucosa (Dragland, Senoo, Wake, Holte, & Blomhoff, 2003; Huh et al., 2003; Oyagi et al., 2010). Gastric mucosa damage can be easily produced by the generation of toxic free radicals (Biswas et al., 2003; Naito et al., 1995) and disorders or decreases in gastric mucosa antioxidant defense systems have been involved in the pathogenesis and progression of gastric ulcers (Kwiecień et al., 2002).…”

Section: Discussionmentioning

confidence: 99%

“…The prevalence of this disease can lead to occur more often due to excessive drinking of alcohol, smoking, stress, infections, nutritional deficiency, abrupt use of nonsteroidal drugs for managing anti‐inflammatory diseases (NSAIDs); it is a multietiologic chronic disease (Alqasoumi, Al‐Sohaibani, Al‐Howiriny, Al‐Yahya, & Rafatullah, 2009; Gisbert, 2005; Süleyman et al., 2009). Pathologically, digestive ulcers located in the gastric and duodenal mucosa induce acute erosive and surface desquamatious ulcerative lesions following exposure to gastric juices, including gastric acid and pepsin (Alqasoumi et al., 2009; Huh et al., 2003). Disorders or decreases in gastric mucosa antioxidant defense systems have been implicated in the pathogenesis and progression of various gastric ulcers (Kwiecień, Brzozowski, Konturek, & Konturek, 2002).…”

Section: Introductionmentioning

confidence: 99%

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Protective effects of a triple‐fermented barley extract (FBe) against HCl/EtOH‐induced gastric mucosa damage in mice

Lim¹,

Song

Park

et al. 2018

Food Science & Nutrition

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This study was designed to observe the possible protective effects of a triple‐fermented barley (Hordeum vulgare L.) extract (FBe) obtained by saccharification and using Saccharomyces cerevisiae and Weissella cibaria in alleviating gastric damage induced by a hydrochloric acid (HCl) and ethanol (EtOH) mixture in mice. After oral administration of FBe (300, 200, and 100 mg/kg) followed by 1 hr before and after the single treatment of HCl/EtOH (H/E) mixture, the hemorrhagic lesion scores, histopathology of the stomach, gastric nitrate/nitrite content, lipid peroxidation, and antioxidant defense systems including catalase and superoxide dismutase activities were observed. Following a single oral treatment of H/E‐induced gastric damages as measured by hemorrhagic gross lesions and histopathological gastric, ulcerative lesions were significantly and dose‐dependently (p < 0.01 or p < 0.05) inhibited in mice, when all three different doses of FBe were administered as compared to those in H/E control mice. In particular, FBe also increased gastric nitrate/nitrite content and strengthened the antioxidant defense, with a decrease in the level of gastric lipid peroxidation, but increased the activities of CAT and SOD. Moreover, the effects of FBe are comparable to that of ranitidine, a reference drug. The obtained results suggest that this fermented barley extract prevented mice from H/E‐induced gastric mucosal damages through the suppression of inflammatory responses and oxidative stress‐responsive free radicals. Thus, FBe can be useful to treat patients suffering from gastric mucosal disorders as a potent food supplement, and thereby, it would increase the necessity of application in the food industry.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Protective effects of a triple‐fermented barley extract (FBe) against HCl/EtOH‐induced gastric mucosa damage in mice

Lim¹,

Song

Park

et al. 2018

Food Science & Nutrition

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“…Previous studies have indicated a cytoprotective effect of A. asiatica ethanol extract against gastric mucosa damage and ulcerative colitis. A. asiatica is also known to be effective in the treatment of oxidant-dependent gastric disease (18,34). In the present study, the anticancer efficacy of eupatilin and its underlying mechanism in human osteosarcoma U-2 OS cells, in vitro, was evaluated.…”

Section: Discussionmentioning

confidence: 97%

“…DA-9601 demonstrated cytoprotective effects against gastric mucosal damage and ulcerative proctitis. Eupatilin has exhibited positive effects in the treatment of oxidant-dependent gastric disorders (18). Eupatilin, apigenin, wogonin and baicalein are all members of the same family of flavonoids.…”

Section: Introductionmentioning

confidence: 99%

Application of eupatilin in the treatment of osteosarcoma

Wu²,

Dong

et al. 2015

Oncology Letters

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Abstract. 5,7-dihydroxy-3' ,4' ,6-trimethoxyflavone, commonly known as eupatilin, is a traditional Asian medicinal plant, which is mainly used for the treatment of gastritis, as well as its use as an anti-inflammatory agent. Eupatilin is a bioactive compound; however, its effects on osteosarcoma (OS) have remained to be elucidated. Therefore, the present study aimed to investigate the effects of eupatilin on this malignant bone tumor, using the U-2 OS cell line. The experimental results revealed that eupatilin inhibited U-2 OS cell growth in a concentration-dependent manner and induced G2/M phase cell cycle arrest and apoptosis. Additionally, western blot analysis indicated that eupatilin was able to trigger the mitochondrial apoptotic pathway, demonstrated by the enhanced Bax/B cell lymphoma-2 ratio, decrease in mitochondrial membrane potential, release of cytochrome c, caspase-3 and -9 activation and poly(ADP-ribose)polymerase cleavage detected in the U-2 OS cells. These results indicated that eupatilin was able to inhibit U-2 OS cancer cell proliferation by the induction of apoptosis via the mitochondrial intrinsic pathway. Eupatilin may therefore represent a novel anticancer drug for use in the treatment of osteosarcoma. IntroductionOsteosarcoma (OS) is considered to be one of the most common and aggressive primary bone tumors of the musculoskeletal system, and predominantly occurs in childhood and adolescence (1,2). There are various potential treatments for OS, including radiotherapy, surgery and chemotherapy; however, the results of these available treatments remain unsatisfactory (3). Significant nephrotoxic and cardiotoxic side-effects are induced by chemopreventative medicines, thereby limiting the efficacy of their use in the treatment of OS (4). Manipulation of apoptosis is one of the major targets in the treatment of cancer.Apoptosis describes genetically-dependent programmed cell death type I, and is characterized by cell shrinkage, signal transduction (5), nucleic condensation (6,7) and DNA and cellular protein degradation (8). Previous studies have revealed that few therapeutic treatments exist that result in an enhanced ability of human tumor cell lines to undergo apoptosis (9,10). Therefore, the development of novel agents to induce or increase the phenomenon of apoptosis present a promising approach for the development of cancer treatments. Novel inducers of apoptosis may provide alternative and efficacious therapeutic anticancer strategies.Flavonoids are associated with multiple biological effects, including antitumor, anti-oxidation, anti-inflammation, antiviral and hepatoprotective activities, as well as in the prevention of cardiovascular diseases (11-16). Eupatilin (5,7-dihydroxy-3',4',6-trimethoxyflavone) is extracted from Artemisia asiatica (A. asiatica) Nakai, and this isolated flavonoid contains pharmacologically active ingredients. Eupatilin has been demonstrated to exert anticancer, anti-oxidative and anti-inflammatory effects (17). A previous report indicated that Stillen™ (DA-9601...

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“…Many Artemisia species have biological activities, such as anti-inflammatory, anti-bacterial, anti-asthmatic, anti-cancerous, and neuroprotective activities. Ethanol extract of A. asiatica has been reported to possess anti-oxidative and anti-inflammatory effects on experimentally induced gastrointestinal damage as well as hepatic and pancreatic lesions (11,12). Based on these pharmacological properties, the first antipeptic ulcer drug prepared from ethanol extracts of A. asiatica, Stillen TM , was developed to treat patients with gastric mucosal ulcers and is commercially available in South Korea and other Asian countries (13).…”

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confidence: 99%

Gastroprotective effects of the isopropanol extract of Artemisia princeps and its gastroretentive floating tablets on gastric mucosal injury

et al. 2017

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In this study, we investigated the gastroprotective effect of an isopropanol extract from the aerial parts of Artemisia princeps (IPAP) and developed a gastroretentive floating tablet of IPAP (IPAP-FR) for maximized local gastroprotective effects. Pre-treatment with IPAP ameliorated the gastric mucosal hemorrhagic lesions in ethanol/HCl-or indomethacin-treated rats. IPAP decreased mucosal hemorrhage of gastric ulcers induced by ethanol or indomethacin plus pyloric ligation in rats. The optimized floating tablet, IPAP-FR, floated on medium surface with more sustained eupatilin release compared to the non-floating control tablet. X-ray photographs in beagle dogs showed that IPAP-FR was retained for > 2 h in the stomach. In the ethanol-induced gastric ulcer rat model, the gastric hemorrhagic lesion was improved more substantially with IPAP-FR compared to the non-floating control tablet. Based on these data, our data suggest that IPAP-FR has an improved therapeutic potential for the treatment of gastric ulcer.

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Inhibitory effects of DA-9601 on ethanol-induced gastrohemorrhagic lesions and gastric xanthine oxidase activity in rats

Cited by 54 publications

References 39 publications

Protective effects of a triple‐fermented barley extract (FBe) against HCl/EtOH‐induced gastric mucosa damage in mice

Protective effects of a triple‐fermented barley extract (FBe) against HCl/EtOH‐induced gastric mucosa damage in mice

Application of eupatilin in the treatment of osteosarcoma

Gastroprotective effects of the isopropanol extract of Artemisia princeps and its gastroretentive floating tablets on gastric mucosal injury

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