Inhibitory effects of different fractions of Nepeta satureioides on melanin synthesis through reducing oxidative stress

Emami, Seyed Ahmad; Yazdian-Robati, Rezvan; Sadeghi, Mehdi; Baharara, Javad; Amini, Elaheh; Salek, Farzaneh; Tayarani‐Najaran, Zahra

doi:10.4103/1735-5362.202455

Cited by 12 publications

(4 citation statements)

References 23 publications

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“…N. cataria is one of the most investigated species of this genus, the results of which confirm its traditional applications [24]. Recent studies have reported promising activities for the Nepeta binaludensis Jamzad and Nepeta satureioides Boiss extracts, e.g., inhibition of melanogenesis and antioxidant activity [24,27]. The main purpose of this study was to investigate the phytochemical composition and to assess the antioxidant, cytotoxic, antifungal, and antibacterial activities of the methanolic, ethanolic, and water extracts of the roots, leaves, and flowers of N. juncea Benth.…”

Section: Introductionmentioning

confidence: 81%

Phytochemical Analysis and Biological Investigation of Nepeta juncea Benth. Different Extracts

Sharifi‐Rad

Epifano

Fiorito

et al. 2020

Plants

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This study was carried out to screen the amount and the classes of secondary metabolites and to evaluate the antioxidant, cytotoxic, antifungal, and antibacterial activities of the methanolic, ethanolic, and water extracts of the roots, leaves, and flowers of Nepeta juncea Benth. The results show that the highest total phenol (69.54 ± 0.31 mg gallic acid equivalents (GAE)/g dry weight), total flavonoid (41.37 ± 0.17 mg quercetin equivalents (QE)/g dry weight), anthocyanin (6.52 ± 0.21 mg cyanidin/100 g dry weight), and tannin (47.36 ± 0.33 mg catechin/g dry weight) concentrations were recorded in the methanolic extract of the leaves of N. juncea. The gas chromatography–mass spectrometry (GC–MS) analysis of the extracts showed that 1,8-cineole, 4aα-7α-7aα-nepetalactone, β-pinene, terpinen-4-ol, and α-terpineol were the major compounds, respectively. The best 2, 2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging and ferric-reducing antioxidant, cytotoxic, antifungal, and antibacterial activities were observed for the methanolic extract of the leaves. For the two latter activities, the best activity was revealed on Staphylococcus aureus, Bacillus cereus, and Candida albicans. The minimum inhibitory concentration (MIC) values for the antimicrobial of the methanolic extract from the leaves were in the range of 25–100 µg/mL, whereas the minimum bactericidal concentration (MBC) values were in the range of 50–200 µg/mL. The results reported herein show that, for the first time in the literature, N. juncea is a remarkable source of antioxidant, antifungal, and antibacterial compounds.

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Section: Introductionmentioning

confidence: 81%

Phytochemical Analysis and Biological Investigation of Nepeta juncea Benth. Different Extracts

Sharifi‐Rad

Epifano

Fiorito

et al. 2020

Plants

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“…showed the aerial parts of P. atlantica have the powerful antioxidant properties(36). Also MeOH and CH 2 Cl 2 fractions of Nepeta satureioides indicated potential effects against melanin production in B16F10 melanoma cells and may contribute in cosmetic formulations of skin care products(37). The derivatives of kojic acid had inhibitory activity on tyrosinase.…”

Section: Discussionmentioning

confidence: 99%

Anti-melanogenesis and anti-tyrosinase properties of Pistacia atlantica subsp. mutica extracts on B16F10 murine melanoma cells

et al. 2018

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Pistacia atlantica (P. atlantica) subsp. mutica has been used in traditional medicine and is famous for its medicinal properties. The aim of this study was to evaluate the effect of methanol (MeOH), n-hexane, dichloromethane (CH2Cl2), n-butanol (BuOH), ethyl acetate (EtOAc), water extracts and essential oil of P. atlantica subsp. mutica on melanin synthesis and oxidative stress in B16F10 melanoma cell line. The B16F10 cells viability after treatment with increasing concentrations of different extracts of the plant (0.2-200 μg/mL) was measured using resazurin. Essential oil composition was identified by gas-chromatography-mass spectrometry (GC-MS) analysis and inhibitory effect on synthesis of melanin, mushroom tyrosinase activity, cellular tyrosinase, and oxidative stress were evaluated by the colorimetric and fluorometric methods. The data showed extracts at concentrations 0.2-200 μg/mL, did not show significant toxicity on melanoma cells but concentrations of 200 μg/mL of essential oil had cytotoxic effect. Pistacia atlantica subsp. mutica could inhibit the mushroom tyrosinase activity. Also the amount of melanin in B16F10 cells declined. In addition, the ability of P. atlantica subsp. mutica extracts in decreasing the amount of reactive oxygen species in melanoma cells revealed remarkable antioxidant activity. In addition, all concentrations of essential oil had no significant effect in this study. The melanogenesis inhibitory and antioxidant effects of P. atlantica subsp. mutica on B16F10 cells may suggest the potential whitening activity of the plant for using in dermatological skin care products and for prevention of skin aging in cosmetic industry.

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“…Nepeta saturejoides (Fig. 4D), locally called "Ostokhodous," is an aromatic and medicinal plant traditionally considered as carminative and used for treating common cold and sinusitis (Emami et al 2017, Hadian et al 2006. Local people utilized N. saturejoides as herbal tea and sedative, and also for treatment of mental problems, foot pain, sore throat, anemia, asthma, common cold, kidney stones, cramps, and muscle injuries.…”

Section: New Reports and New Usesmentioning

confidence: 99%

Ethnobotany of plants used by indigenous communities in Birjand, a dry region with rich local traditional knowledge in eastern Iran

Mohammadi,

Moazzeni,

Pirani

et al. 2023

Ethnobot. Res. App.

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Background: Despite locating in a dry region with a mostly homogeneous ethnic group, South Khorassan province has a high diversity of medicinal plant uses and rich cultural background. The current study was conducted in Birjand (South Khorassan province) and its 18 adjacent villages to document information concerning the plants used and introduce important plant species using ethnobotanical indices.Methods: In total, 59 people were interviewed about local plants and their utilizations using a semi-structured questionnaire and personal observations between 2018 to 2020. All of the documented plants were collected and identified. The obtained data were analyzed using quantitative ethnobotanical indices.Results: A total of 119 plant species belonging to 93 families were identified. Asteraceae, Apiaceae, and Lamiaceae were the most used plant families. The most frequently plant part used was the aerial part. Decoction was reported as the most common preparation method. The highest UV and RFC values were recorded for Sclerorhachis leptoclada, Scrophularia leucoclada, and Nepeta saturejoides. The highest ICF was reported for digestive system disorders. 35 species showed fidelity level value of 100%. Conclusions:The present study reveals that the people in Birjand and the adjacent areas have a rich indigenous knowledge regarding the plants. Moreover, plants still maintain their place in people's lives, especially as medicine and food. Older people were more knowledgeable than young ones. The results of this study can be used for screening plant species for future phytochemical and pharmacological studies. The present study will facilitate the protection programs of the endangered plants in Birjand area.

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Inhibitory effects of different fractions of Nepeta satureioides on melanin synthesis through reducing oxidative stress

Cited by 12 publications

References 23 publications

Phytochemical Analysis and Biological Investigation of Nepeta juncea Benth. Different Extracts

Phytochemical Analysis and Biological Investigation of Nepeta juncea Benth. Different Extracts

Anti-melanogenesis and anti-tyrosinase properties of Pistacia atlantica subsp. mutica extracts on B16F10 murine melanoma cells

Ethnobotany of plants used by indigenous communities in Birjand, a dry region with rich local traditional knowledge in eastern Iran

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