Inhibitory Effects of Ginseng (Panax ginseng) Berry on Tumour Promotion and Inflammatory Ear Oedema Induced by TPA

Yasukawa, Ken; Whang, Wan Kyunn; Ko, Sung-Kwon

doi:10.6000/1929-5634.2015.04.04.6

Cited by 2 publications

(2 citation statements)

References 25 publications

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“…Meyer) is one of the perennial medicinal herb plants and has been used as an important medicinal plant for thousands of years (Hu 1976;). Recently, the pharmaceutical compounds with high utility have been discovered in the various ginseng tissues including fruit, leaves and stems, and they are used importantly in health functional foods, pharmaceuticals, and cosmetics (Jang et al 2014;Seo et al 2015;Yasukawa et al 2016). With the recently developed PacBio single-molecule real-time (SMRT) Iso-seq analysis, we successfully provided to more accurate information of the full-length transcriptome sequences of P. ginseng (Jo et al 2017;Hong et al 2018).…”

Section: Introductionmentioning

confidence: 99%

Functional characterization of gibberellin signaling-related genes in Panax ginseng

et al. 2021

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Gibberellins (GAs) are essential phytohormones for plant growth that influence developmental processes and crop yields. Recent functional genomic analyses of model plants have yielded good characterizations of the canonical GA signaling pathways and related genes. Although Panax ginseng has long been considered to have economic and medicinal importance, functional genomic studies of the GA signaling pathways in this crucial perennial herb plant have been rarely conducted. Here, we identified and performed functional analysis of the GA signaling-related genes, including PgGID1s, PgSLY1s, and PgRGAs. We confirmed that the physiological role of GA signaling components in P. ginseng was evolutionarily conserved. In addition, the important functional domains and amino acid residues for protein interactions among active GA, GID1, SCF SLY1 , and RGA were also functionally conserved. Prediction and comparison of crystallographic structural similarities between PgGID1s and AtGID1a supported their function as GA receptors. Moreover, the subcellular localization and GAdependent promotion of DELLA degradation in P. ginseng was similar to the canonical GA signaling pathways in other plants. Finally, we found that overexpression of PgRGA2 and PgSLY1-1 was sufficient to complement the GA-related phenotypes of atgid1a/c double-and rga quintuple-mutants, respectively. This critical information for these GA signaling genes has the potential to facilitate future genetic engineering and breeding of P. ginseng for increased crop yield and production of useful substances.

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Section: Introductionmentioning

confidence: 99%

Functional characterization of gibberellin signaling-related genes in Panax ginseng

et al. 2021

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“…The medicinal constituents of ginseng are derived from the roots, in which the active pharmacological compounds gradually increase over long periods of successive cultivation (4–6 years) [ 3 ]. Recently, the aerial parts, including ginseng berries, leaves and sprouts, have been discovered as a source of medicinal compounds [ 4 , 5 , 6 ]. Studies on ginseng have focused on its pharmacological effects on humans [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

Isoform Sequencing Provides a More Comprehensive View of the Panax ginseng Transcriptome

Lee

Hong

et al. 2017

Genes

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Korean ginseng (Panax ginseng C.A. Meyer) has been widely used for medicinal purposes and contains potent plant secondary metabolites, including ginsenosides. To obtain transcriptomic data that offers a more comprehensive view of functional genomics in P. ginseng, we generated genome-wide transcriptome data from four different P. ginseng tissues using PacBio isoform sequencing (Iso-Seq) technology. A total of 135,317 assembled transcripts were generated with an average length of 3.2 kb and high assembly completeness. Of those unigenes, 67.5% were predicted to be complete full-length (FL) open reading frames (ORFs) and exhibited a high gene annotation rate. Furthermore, we successfully identified unique full-length genes involved in triterpenoid saponin synthesis and plant hormonal signaling pathways, including auxin and cytokinin. Studies on the functional genomics of P. ginseng seedlings have confirmed the rapid upregulation of negative feed-back loops by auxin and cytokinin signaling cues. The conserved evolutionary mechanisms in the auxin and cytokinin canonical signaling pathways of P. ginseng are more complex than those in Arabidopsis thaliana. Our analysis also revealed a more detailed view of transcriptome-wide alternative isoforms for 88 genes. Finally, transposable elements (TEs) were also identified, suggesting transcriptional activity of TEs in P. ginseng. In conclusion, our results suggest that long-read, full-length or partial-unigene data with high-quality assemblies are invaluable resources as transcriptomic references in P. ginseng and can be used for comparative analyses in closely related medicinal plants.

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Inhibitory Effects of Ginseng (Panax ginseng) Berry on Tumour Promotion and Inflammatory Ear Oedema Induced by TPA

Cited by 2 publications

References 25 publications

Functional characterization of gibberellin signaling-related genes in Panax ginseng

Functional characterization of gibberellin signaling-related genes in Panax ginseng

Isoform Sequencing Provides a More Comprehensive View of the Panax ginseng Transcriptome

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