Inhibitory Effects of Laser Irradiation on Peripheral Mammalian Nerves and Relevance to Analgesic Effects: A Systematic Review

Chow, Roberta; Armati, Patricia J.; Laakso, E-Liisa; Bjordal, Jan Magnus; Baxter, G. David

doi:10.1089/pho.2010.2928

Cited by 247 publications

(144 citation statements)

References 82 publications

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“…In in vivo studies, it has been shown that laser irradiation can partially or totally inhibit nerve conduction and can affect conduction velocity and action potential amplitude [31]. Studies on rat models showed that laser radiation inhibits Aδ and C fibre transmission of nociceptive stimuli induced by cold/heat, chemicals and proinflammatory substances [32,33].…”

Section: Discussionmentioning

confidence: 99%

Photobiomodulation therapy by NIR laser in persistent pain: an analytical study in the rat

et al. 2017

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Over the past three decades, physicians have used laser sources for the management of different pain conditions obtaining controversial results that call for further investigations. In order to evaluate the pain relieving possibilities of photobiomodulation therapy (PBMT), we tested two near infrared (NIR) laser systems, with different power, against various kinds of persistent hyperalgesia animal models. In rats, articular pain was reproduced by the intra-articular injection of sodium monoiodoacetate (MIA) and complete Freund's adjuvant (CFA), while compressive neuropathy was modelled by the chronic constriction injury of the sciatic nerve (CCI). In MIA and CFA models, (NIR) laser (MLS-Mphi, ASA S.r.l., Vicenza, Italy) application was started 14 days after injury and was performed once a day for a total of 13 applications. In MIA-treated animals, the anti-hyperalgesic effect of laser began 5 min after treatment and vanished after 60 min. The subsequent applications evoked similar effects. In CFA-treated rats, laser efficacy started 5 min after treatment and disappeared after 180 min. In rats that underwent CCI, two treatment protocols with similar fluence but different power output were tested using a new experimental device called Multiwave Locked System laser (MLS-HPP). Treatments began 7 days after injury and were performed during 3 weeks for a total of 10 applications. Both protocols reduced mechanical hyperalgesia and hindlimb weight bearing alterations until 60 min after treatment with a higher efficacy recorded for the animals treated using the higher power output. In conclusion, this study supports laser therapy as a potential treatment for immediate relief of chronic articular or neuropathic pain.

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Section: Discussionmentioning

confidence: 99%

Photobiomodulation therapy by NIR laser in persistent pain: an analytical study in the rat

et al. 2017

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“…Apesar de não haver uma padronização dos parâmetros do laser para obtenção de efeito analgésico, existem algumas sugestões para tratamento da dor musculoesquelética com energias que variam de 6 a 24 J por ponto para o laser infravermelho (820 a 830 nm), sendo recomendado 6 J para lesões agudas pequenas e acima de 10 J para aquelas maiores 8 , as quais também são recomendadas pela Associação Mundial de Laserterapia (WALT). No presente estudo foram empregadas energias de 3, 6 e 12 J, as quais são localizadas dentro da janela terapêutica 49 , com o objetivo de avaliar qual delas seria melhor para obtenção de hipoalgesia.…”

Section: Discussionunclassified

Efeitos local e sistêmico do laser de baixa potência no limiar de dor por pressão em indivíduos saudáveis

2012

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| Low-power laser is used as a therapeutic tool for pain control. However, it is still questioned its real effects and the more effective dosimetry for this analgesic effect. Therefore, this study aimed at assessing the local and systemic effects of low-power laser on pressure pain threshold in healthy subjects. One hundred and fifty subjects were randomized into five groups: Control, Placebo Laser, 3 J, 6 J, and 12 Joules. A pressure algometer was used to assess pressure pain threshold in five different periods. In the dominant hand, laser and algometry were performed to determine the local effect, and in the dominant leg, algometry was performed to assess the systemic effect of low-power laser. There was a reduction on local pressure pain threshold in the Group 3 J compared with Control (p=0.0016) and Placebo (p=0.004) groups. No systemic changes on pressure pain threshold were observed. Low-power laser with energy of 3 J decreased pressure pain threshold in healthy subjects, but there was no systemic change.Keywords | laser therapy; pain measurement; pain threshold; analgesia.RESUMO | O laser de baixa potência é utilizado como recurso terapêutico para controle da dor. Porém, ainda é questionado o real efeito como também a dosimetria mais eficaz para esse efeito analgésico. Assim, este estudo teve como objetivo avaliar os efeitos local e sistêmico do laser de baixa potência no limiar de dor por pressão, em indivíduos saudá-veis. Cento e cinquenta indivíduos foram distribuídos aleatoriamente em cinco grupos: Controle, Laser Placebo, 3 J, 6 J e 12 J. Para avaliar o limiar de dor, utilizou-se um algômetro de pressão em cinco tempos distintos. Na região da mão dominante do indivíduo, foi realizado o laser e a algometria para verificar o efeito local. Já naquela da perna dominante, realizou-se somente a algometria para verificar efeito sistê-mico do laser de baixa potência. Houve redução local do limiar de dor por pressão no Grupo 3 J em comparação com os grupos Controle (p=0,0016) e Placebo (p=0,004), e não houve alteração sistêmica do limiar de dor por pressão. O laser de baixa potência, quando utilizado com energia de 3 J, reduziu o limiar de dor por pressão local em indivíduos saudáveis, porém não houve alteração sistêmica.Descritores | terapia a laser; medição da dor; limiar da dor; analgesia.

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“…Some literature reported positive results for tissue repair and anti-inflammatory effects when the range of 5-55 mW/cm2 was employed [103][104][105], while higher irradiances of 300-1730 mW/cm2 was recommended for analgesic purposes [106].…”

Section: Irradiancementioning

confidence: 99%

The Use of Photomedicine in Musculoskeletal Pain

Al-Shenqiti¹

2017

Photomedicine - Advances in Clinical Practice

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Musculoskeletal pain is a major cause of disability. Myofascial trigger points (MTrPs) in particular are a common source of pain in a substantial number of patients presenting at a pain clinic. Many different invasive and non-invasive forms have been advocated to the treatment of MTrPs. However, favourable outcome rates are inconsistent and some of these treatment forms described are often painful and have potentially dangerous side effects. Photomedicine including the coherent light sources (lasers) and more recently, non-coherent light sources have been reported to be beneficial in soft tissue lesions including MTrPs. Their beneficial therapeutic effects can be obtained without undesired effects. The main intentions of this chapter are to bring the attention of the doctors and physical therapists to the scientific approach of photomedicine, in particular laser therapy for the relief of pain arising from MTrPs, and to demonstrate how this type of therapy can be utilized in a rational manner for the relief of musculoskeletal pain. In addition, it has been found necessary to include or to start with an overview of the recently recognized diagnostic and therapeutic importance of MTrPs. Attention will therefore first be drawn mainly to incidence, types, aetiology, clinical diagnostic criteria and conventional forms of MTrPs.

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Inhibitory Effects of Laser Irradiation on Peripheral Mammalian Nerves and Relevance to Analgesic Effects: A Systematic Review

Cited by 247 publications

References 82 publications

Photobiomodulation therapy by NIR laser in persistent pain: an analytical study in the rat

Photobiomodulation therapy by NIR laser in persistent pain: an analytical study in the rat

Efeitos local e sistêmico do laser de baixa potência no limiar de dor por pressão em indivíduos saudáveis

The Use of Photomedicine in Musculoskeletal Pain

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