Inhibitory Effects of Salvianolic Acid B on the High Glucose-Induced Mesangial Proliferation via NF-.KAPPA.B-Dependent Pathway

Luo, Pei; Tan, Zhenghuai; Zhang, Zhifeng; Li, Honghao; Zhang, Mo

doi:10.1248/bpb.31.1381

Cited by 48 publications

(36 citation statements)

References 39 publications

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“…13) It was reported to possess hepatoprotective and antifibrogenic capabilities, 28) inhibit high glucose-induced mesangial cells proliferation and extracellular matrix production, 29) enhance angiogenic processes, and protect against ischemia-reperfusion injury in the skin, heart, and brain, possibly by inhibiting oxidative stress, and improving energy metabolism. 14,30,31) Overall, these results indicate that Sal B protected SH-SY5Y cells against MPP ϩ -induced apoptosis by relieving oxidative stress and thus modulating the apoptotic process.…”

Section: Disccusionmentioning

confidence: 99%

Withdrawal: Salvianolic Acid B Protects SH-SY5Y Neuroblastoma Cells from 1-Methyl-4-phenylpyridinium-Induced Apoptosis

Zeng

Tang

et al. 2010

Biological & Pharmaceutical Bulletin

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Section: Disccusionmentioning

confidence: 99%

Withdrawal: Salvianolic Acid B Protects SH-SY5Y Neuroblastoma Cells from 1-Methyl-4-phenylpyridinium-Induced Apoptosis

Zeng

Tang

et al. 2010

Biological & Pharmaceutical Bulletin

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“…Generally, the compounds with higher degree of connectivity are more potent pharmacologically (29). A few of the compounds identified here as having a high-degree of connectivity (Table Ⅳ) have been reported in the literature (30)(31)(32). These results overall suggest that HXHY herbs may simultaneously target multiple proteins.…”

Section: Discussionsupporting

confidence: 60%

In silico search for multi-target therapies for osteoarthritis based on 10 common Huoxue Huayu herbs and potential applications to other diseases

Zheng

Zhuang

et al. 2014

Molecular Medicine Reports

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Abstract. Huoxue Huayu (HXHY) has been widely used in traditional Chinese medicine (TCM) as a key therapeutic principle for osteoarthritis (OA), and related herbs have been widely prescribed to treat OA in the clinic. The aims of the present study were to explore a multi-target therapy for OA using 10 common HXHY herbs and to investigate their potential applications for treatment of other diseases. A novel computational simulation approach that integrates chemical structure, ligand clusters, chemical space and drug-likeness evaluations, as well as docking and network analysis, was used to investigate the properties and effects of the herbs. The compounds contained in the studied HXHY herbs were divided into 10 clusters. Comparison of the chemical properties of these compounds to those of other compounds described in the DrugBank database indicated that the properties of the former are more diverse than those of the latter and that most of the HXHY-derived compounds do not violate the 'Lipinski's rule of five'. Docking analysis allowed for the identification of 39 potential bioactive compounds from HXHY herbs and 11 potential targets for these compounds. The identified targets were closely associated with 49 diseases, including neoplasms, musculoskeletal, nervous system and cardiovascular diseases. Ligand-target (L-T) and ligand-target-disease (L-T-D) networks were constructed in order to further elucidate the pharmacological effects of the herbs. Our findings suggest that a number of compounds from HXHY herbs are promising candidates for mult-target therapeutic application in OA and may exert diverse pharmacological effects, affecting additional diseases besides OA. IntroductionOsteoarthritis (OA) is a degenerative joint disease, which causes chronic pain and functional restrictions in the affected joints (1). At present, there is no effective treatment for reversing or preventing its onset. Non-steroidal anti-inflammatory drugs (NSAIDs) are mainly used for treating OA, particularly in the early stages of the disease, but these drugs are often associated with clinically adverse effects (2). Furthermore, the social and economic cost related to OA remains particularly high (3). Therefore, ongoing research attempts to develop improved therapeutic strategies for OA.Several lines of evidence suggest that treatment that aims at a number of targets at once may be more effective against complex diseases such as OA (4,5). On the other hand, traditional Chinese medicine (TCM), a complex system employing multiple components and targets, has been recognized in Western countries as a popular complementary and alternative medicinal approach. TCM has been used in the treatment of OA, and often has fewer side-effects than those reported for NSAIDs (6-8). Those reports indicate that TCM may provide a novel promising strategy for treatment of OA.Huoxue Huayu (HXHY) has been widely used in TCM as a key therapeutical principle for OA in China (9,10). Ten common HXHY herbs, Ligusticum chuanxiong, Salvia miltiorrhiza, Strychnos nux-v...

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“…Arachidonic acids released by mesangial cells in response to HG treatment can be metabolized through three different pathways: the cyclooxygenase, lipoxygenase, and cytochrome P-450 pathways. Many studies have reported that NF-B and cPLA 2 are downstream of the HG-mediated signal pathways and that cPLA 2 is downstream of NF-B (29,31,40), but this requires further study. It is interesting that the activation of PKC, phosphatidylinositol 3-kinase (PI3K), p38 MAPK, and JNK was not involved in HG-induced CB 1 R activation, based on our findings that pretreatment with bisindolylmaleimide I (a PKC inhibitor), LY294002 (a PI3K inhibitor), SB203580 (a p38 MAPK inhibitor), or SP200125 (a JNK inhibitor) did not block the HGinduced increase in CB 1 R protein levels (data not shown).…”

Section: Discussionmentioning

confidence: 99%

Cannabinoid receptor 1 mediates high glucose-induced apoptosis via endoplasmic reticulum stress in primary cultured rat mesangial cells

Lim

Park

et al. 2011

American Journal of Physiology-Renal Physiology

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SH.Cannabinoid receptor 1 mediates high glucose-induced apoptosis via endoplasmic reticulum stress in primary cultured rat mesangial cells. Am J Physiol Renal Physiol 301: F179 -F188, 2011. First published February 16, 2011 doi:10.1152/ajprenal.00032.2010.-The endocannabinoid system in animals and humans is involved in the onset of diverse diseases, including obesity and diabetic nephropathy, which is a major end-stage renal disease characterized by high glucose (HG)-induced apoptosis of mesangial cells. Endocannabinoids induce physiological and behavioral effects by activating two specific receptors, cannabinoid receptor 1 (CB 1R) and cannabinoid receptor 2 (CB2R). However, the pathophysiology of CB 1R in diabetic nephropathy has not been elucidated. We investigated the effects of HG on CB 1R expression and its signaling pathways in primary cultured rat mesangial cells. HG significantly increased CB 1R mRNA and protein levels in a time-dependent manner and induced CB 1R internalization. NF-B and cPLA 2 were involved in the HG-induced increase in CB 1R levels. Using a CB1R antagonist (AM251) and CB1 siRNA transfection, we showed that HG-induced CB 1R is linked to apoptosis. Specifically, HG inhibited the expression of GRP78, but induced increases in endoplasmic reticulum (ER) stress proteins, including phosphorylated (p)-protein kinase-like ER-associated kinase, p-eukaryotic initiation factor 2␣, p-activating transcription factor-4, and C/EBP homologous protein. In addition, HG increased the Bax/Bcl-2 ratio and increased the amounts of cleaved poly(ADP-ribose) polymerase and caspase-3. These apoptotic effects were prevented by AM251 and by the downregulation of CB 1R expression by small interfering RNA. We propose a mechanism by which blockade of CB 1R attenuates HG-induced apoptosis in rat mesangial cells. Our findings suggest that blockade of CB 1R may be a potential therapy in diabetic nephropathy. endocannabinoid system DIABETIC NEPHROPATHY IS CHARACTERIZED by hyperglycemia-induced dysfunction of mesangial cells (21). In an environment of high glucose (HG), renal mesangial cells undergo cascades of deleterious reactions, including cell injury and extracellular matrix deposition, which lead to glomeruli dysfunction (1,25,49). Mesangial cell apoptosis promoted by HG contributes to the development of diabetic nephropathy (22,40).Endocannabinoids are endogenous lipid mediators with a wide range of biological effects, similar to those of marijuana. The endocannabinoid system (ECS) regulates synaptic plasticity, emotional responses, energy homeostasis, and glucose metabolism (44). Dysregulation of ECS is involved in the onset of obesity and diabetic nephropathy (12). Barutta et al. (5) have reported that cannabinoid receptor 1 (CB 1 R) was overexpressed within glomeruli in diabetic mice and CB 1 blockade prevented diabetes-induced albuminuria. It has been also reported that the condition of HG increased the endogenous ligands of the ECS, N-arachidonoyl ethanolamine (AEA) and 2-arachidonylglycerol ( 2-AG) in vivo...

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Inhibitory Effects of Salvianolic Acid B on the High Glucose-Induced Mesangial Proliferation via NF-.KAPPA.B-Dependent Pathway

Cited by 48 publications

References 39 publications

Withdrawal: Salvianolic Acid B Protects SH-SY5Y Neuroblastoma Cells from 1-Methyl-4-phenylpyridinium-Induced Apoptosis

Withdrawal: Salvianolic Acid B Protects SH-SY5Y Neuroblastoma Cells from 1-Methyl-4-phenylpyridinium-Induced Apoptosis

In silico search for multi-target therapies for osteoarthritis based on 10 common Huoxue Huayu herbs and potential applications to other diseases

Cannabinoid receptor 1 mediates high glucose-induced apoptosis via endoplasmic reticulum stress in primary cultured rat mesangial cells

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