Inhibitory effects of Solidago chilensis Meyen hydroalcoholic extract on acute inflammation

Tamura, Eduardo Koji; Jimenez, Renata Spada; Waismam, Kaline; Gobbo‐Neto, Leonardo; Lopes, Norberto Peporine; Malpezzi-Marinho, Elena A.L.; Marinho, E.A.V.; Farsky, Sandra

doi:10.1016/j.jep.2009.01.029

Cited by 41 publications

(38 citation statements)

References 31 publications

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“…Solidago chilensis Meyen (Asteraceae) possui ação antibacteriana (Zampini et al, 2007), grande atividade antioxidante (Russo & garbarino, 2008) efeito antinflamatório, por meio do extrato hidroalcoólico extraído de partes aéreas e, também atua em processos de edema e migração de leucócitos (Tamura et al, 2009). Seu fluído possui efeito comprovado no tratamento de lombalgia (Silva et al, 2010).…”

Section: Resultado E Discussãounclassified

Espécies bioativas em áreas úmidas do Planalto Catarinense

Silva

Bortoluzzi

Gomes

et al. 2013

Rev. bras. plantas med.

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O objetivo deste trabalho foi levantar e identificar as espécies vegetais que ocorrem em áreas úmidas (banhados) do Planalto Catarinense e associá-las aos seus respectivos potenciais bioativos, validados em testes laboratoriais ou relatados em estudos etnobotânicos. O estudo foi realizado em 12 áreas de banhados localizadas em fazendas com reflorestamentos comerciais de espécies exóticas de propriedade da Empresa Klabin S.A. A amostragem da vegetação foi realizada por meio de transecção no sentido transversal na maior largura dos banhados e na área de transição destes com a área mais drenada (em faixa limitada de três metros), onde foram coletados os espécimes férteis a cada metro da transecção. Após a identificação das espécies foi realizada uma revisão bibliográfica sobre o potencial bioativo das mesmas junto à bases de dados científicos utilizando-se os trabalhos que atestam o potencial e também os trabalhos que valorizam o conhecimento de populações locais. Nas áreas amostradas foram identificadas 235 espécies classificadas em 40 famílias botânicas. Destas, 28 espécies, classificadas em 11 famílias, possuem potencial bioativo. Do total de espécies identificadas, 18 apresentaram potencial validado cientificamente e 10 são citadas quanto ao seu potencial em trabalhos de etnobotânica. Ainda é pouco conhecida a diversidade de banhados no Planalto Catarinense sendo necessário mais estudo para o conhecimento da flora local. O estudo mostrou um grande número de espécies com potencial validado e que poderiam ser utilizadas pela população, enquanto outras que merecem pesquisas complementares.

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Section: Resultado E Discussãounclassified

Espécies bioativas em áreas úmidas do Planalto Catarinense

Silva

Bortoluzzi

Gomes

et al. 2013

Rev. bras. plantas med.

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“…Tamura et al (2009) developed pharmacological studies concerning this species and identified the anti-inflammatory activity of its leaves. It was confirmed in this research by the mention of the use of S. chilensis leaves in infusion against general inflammations and poultice in cases of bone fracture.…”

Section: Discussionmentioning

confidence: 99%

Medicinal plants used in Rondônia, Western Amazon, Brazil

Santos

Lima

Oliveira

2014

Rev. bras. plantas med.

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ABSTRACT:This study refers to the use of medicinal plants by populations in the Western Amazon and provides information that can be used in phytochemical studies. It draws upon the traditional knowledge regarding the use of medicinal plants in five regions of the state of Rondônia, in the Brazilian Amazon, focusing on native species. The field research was carried out in five municipalities of the state of Rondônia: Ariquemes, Buritis, Candeias do Jamari, Cujubim and Itapoa do Oeste, characterized by primary economic sectors: agriculture, cattle farming, plant extraction and mineral exploration. Structured interviews were applied to 227 persons chosen because of their prestige in the communities in relation to the knowledge and use of medicinal plants, identifying the therapeutic purpose, parts of the plant used and methods of preparation. The species were taxonomically identified. The ethnobotanic knowledge (inferred by the number of uses of medicinal plants per person) was correlated with the Brazilian region of origin, age, and gender of the interviewees. According to the collected data, 34 botanical families and 53 native species were identified. Of the 53 species, only 7 occur exclusively in the Amazon Forest: Theobroma grandiflorum (Willd. ex Spreng.) K. Schum., Psidium densicomum Mart. ex DC, Piper cavalcantei Yunck., Pilocarpus microphyllus Stapf ex Wardlew., Euterpe oleracea Mart., Croton cajucara Benth., Baccharis altimontana G. Heiden. The most common disorders treated with the plants were kidney problems, influenza, generalized infections and inflammations, malaria and high blood pressure. Leaves were the most used parts in preparations. Barks, fruits, roots, flowers, stems, seeds, oils, buds, tubercles, and rhizomes were also mentioned. Thirteen forms of preparations were recorded, and infusion and decoction were the most used. Syrups, juices, flour, sap, oil and parts of the plant blended with milk, honey and coffee or flamed, macerated and in the form of poultice, were also found. Persons from the Southeast region had more information compared with persons from the other regions; persons in the age groups between 50-59, 60-69 and 70-79 had more information in comparison with the other age groups; and the female interviewees mentioned significantly more uses of medicinal plants than the male ones. The relatively small number of native Amazon species identified can be the result of the loss of knowledge about medicinal plants in the Amazon because of internal migration, extinction of local indigenous groups, increasing urbanization and consequent globalization of the lifestyles. Keywords: Ethnobotany, Phytotherapy, Traditional Medicine.RESUMO: Plantas medicinais usadas em Rondônia, Amazônia Ocidental, Brasil. Este estudo se refere ao uso de plantas medicinais por populações da Amazônia Ocidental, fornece informações passíveis de utilização em estudos fitoquímicos e resgata o conhecimento tradicional a respeito do uso de plantas medicinais em cinco regiões do estado de Rondônia na Amazônia Brasileira...

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“…Previous ethnopharmacological and clinical studies have described this species as having gastric protective (SchemedaHirchmann et al, 2002), wound-healing (Facury-Neto et al, 2004), antifungal (Webster et al, 2008), and anti-inflammatory properties (Tamura et al, 2009). Recently, there have been considerable advances in the treatment of lumbago (Da Silva et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

Hypolipidemic effects ofSolidago chilensishydroalcoholic extract and its major isolated constituent quercetrin in cholesterol-fed rats

Junior¹,

Piato²,

Conterato³

et al. 2015

Pharmaceutical Biology

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(2015) Hypolipidemic effects of Solidagochilensis hydroalcoholic extract and its major isolated constituent quercetrin in cholesterol-fed rats, Pharmaceutical Biology, 53:10, 1488-1495, DOI: 10.3109/13880209.2014 Objective: This study evaluates the hypolipidemic and antioxidant effects of hydroalcoholic extract (HE) and quercetrin from S. chilensis aerial parts in cholesterol-fed rats. Materials and methods: The HE was analyzed by high-performance liquid chromatography, followed by quercetrin isolation. Hypercholesterolemic rats (1% cholesterol and 0.5% cholic acid for 15 d) were treated with HE (150, 300, and 600 mg/kg p.o.; n ¼ 6), simvastatin (4 mg/kg p.o.; n ¼ 6), or quercetrin (10 mg/kg p.o.; n ¼ 6) once a day for 30 d. During this period, a highcholesterol diet was maintained until the 30th day of treatment.Results: Rats treated with HE (150, 300, and 600 mg/kg) and quercetrin showed decreased serum levels of total cholesterol (À19.9, À27.5, À31.0, and À39.4%), lipoprotein-cholesterol (À36.0, À37.5, À43.3, and À59.4%), and triacylglycerides (À15.6, À23.5, À29.8, and À27.2%) when compared with the control group similar to simvastatin. Moreover, treatment with HE and quercetrin decreased hepatic 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase activity (35.1% on average) and increased fecal cholesterol levels (38.2% on average). Discussion and conclusions: Our results suggest that hypolipidemic effects of HE are associated with it modulating the activity of HMG-CoA reductase and its interference in the reabsorption and/or excretion of intestinal lipids. Solidago chilensis and its main constituent, quercetrin, may thus be effective as cholesterol-lowering agents and in preventing atherosclerosis.

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Inhibitory effects of Solidago chilensis Meyen hydroalcoholic extract on acute inflammation

Cited by 41 publications

References 31 publications

Espécies bioativas em áreas úmidas do Planalto Catarinense

Espécies bioativas em áreas úmidas do Planalto Catarinense

Medicinal plants used in Rondônia, Western Amazon, Brazil

Hypolipidemic effects ofSolidago chilensishydroalcoholic extract and its major isolated constituent quercetrin in cholesterol-fed rats

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