2015
DOI: 10.3390/molecules20058988
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Inhibitory Effects of Verrucarin A on Tunicamycin-Induced ER Stress in FaO Rat Liver Cells

Abstract: Endoplasmic reticulum (ER) stress is linked with development and maintenance of cancer, and serves as a therapeutic target for treatment of cancer. Verrucarin A, isolated from the broth of Fusarium sp. F060190, showed potential inhibitory activity on tunicamycin-induced ER stress in FaO rat liver cells. In addition, the compound decreased tunicamycin-induced GRP78 promoter activity in a dose dependent manner without inducing significant inhibition of luciferase activity and cell growth for 6 and 12 h. Moreover… Show more

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Cited by 5 publications
(3 citation statements)
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References 14 publications
(15 reference statements)
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“…Tunicamycin may reverse drug resistance and improve the treatment of hepatocellular carcinomas by targeting the DPAGT1/AKT/ABCG2 signaling pathway [19]. ERS is associated with cancer development and maintenance, and is a therapeutic target for cancer treatment [20]. Tunicamycin inhibited N-glycosylation biosynthetic processes to cause ERS and toxicity in normal tissues [21].…”
Section: Discussionmentioning
confidence: 99%
“…Tunicamycin may reverse drug resistance and improve the treatment of hepatocellular carcinomas by targeting the DPAGT1/AKT/ABCG2 signaling pathway [19]. ERS is associated with cancer development and maintenance, and is a therapeutic target for cancer treatment [20]. Tunicamycin inhibited N-glycosylation biosynthetic processes to cause ERS and toxicity in normal tissues [21].…”
Section: Discussionmentioning
confidence: 99%
“…TUNI triggers stress by inhibiting the N -linked glycosylation of newly synthesised proteins in the ER [ 32 ]. This glycosylation controls both the process and the quality of folding [ 33 ]. GRP78 is recruited to bind to the unfolded proteins if the hydrophobic parts of the amino acid chain are not successfully buried in the protein interior [ 34 ].…”
Section: Discussionmentioning
confidence: 99%
“…Cancer research has focused on the instigation of ERS-induced apoptosis in tumors [51], providing evidence for the importance of ERS in apoptotic regulation. Even under normal conditions, organs that are highly efficient protein synthesizers are challenged by ERS and ERS-induced apoptosis, including the liver [52], mammary glands [53], and intestines [54]. NF-κB is considered central to intestinal inflammation, and can be activated by pathogenic bacteria, thus the intestine is naturally exposed to the co-effects of NF-κB and ERS.…”
Section: Crosstalk Between Ers and Inflammationmentioning
confidence: 99%