Inhibitory Effects of α-Pinene on Hepatoma Carcinoma Cell Proliferation

Chen, Weiqiang; Xu, Bin; Mao, Jianwen; Wei, Fengxiang; Li, Ming; Liu, Tao; Jin, Xiaobao; Zhang, Lirong

doi:10.7314/apjcp.2014.15.7.3293

Cited by 38 publications

(23 citation statements)

References 15 publications

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“…Alpha-pinene from a steam distillation extract of pine needles exhibits anti-proliferative effect on human hepatocellular carcinoma BEL-7402 cells by arresting cell cycle at the G2/M phase, downregulating CDC25C expression, while reducing CDK1 activity [241]. Rocaglamide-A (Roc-A), a natural anticancer compound from Aglaia , induces a rapid phosphorylation of CDC25A and its subsequent degradation, thereby blocking cell cycle progression of tumor cells at the G1-S phase [242].…”

Section: Cell Cycle Regulation By Natural Compounds Affecting Other Ementioning

confidence: 99%

Natural Compounds as Modulators of Cell Cycle Arrest: Application for Anticancer Chemotherapies

et al. 2017

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Natural compounds from various plants, microorganisms and marine species play an important role in the discovery novel components that can be successfully used in numerous biomedical applications, including anticancer therapeutics. Since uncontrolled and rapid cell division is a hallmark of cancer, unraveling the molecular mechanisms underlying mitosis is key to understanding how various natural compounds might function as inhibitors of cell cycle progression. A number of natural compounds that inhibit the cell cycle arrest have proven effective for killing cancer cells in vitro, in vivo and in clinical settings. Significant advances that have been recently made in the understanding of molecular mechanisms underlying the cell cycle regulation using the chemotherapeutic agents is of great importance for improving the efficacy of targeted therapeutics and overcoming resistance to anticancer drugs, especially of natural origin, which inhibit the activities of cyclins and cyclin-dependent kinases, as well as other proteins and enzymes involved in proper regulation of cell cycle leading to controlled cell proliferation.

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Section: Cell Cycle Regulation By Natural Compounds Affecting Other Ementioning

confidence: 99%

Natural Compounds as Modulators of Cell Cycle Arrest: Application for Anticancer Chemotherapies

et al. 2017

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“…In previous study, we found that pine needle oil exhibited significant inhibitory effect on hepatoma carcinoma BEL-7402 cells in vitro and discussed the mechanism preliminarily (7).…”

Section: Introductionmentioning

confidence: 96%

Anti-tumor effect of α-pinene on human hepatoma cell lines through inducing G2/M cell cycle arrest

Chen

Liu

et al. 2015

Journal of Pharmacological Sciences

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141

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Pine needle oil from crude extract of pine needles has been used as an anti-cancer agent in Traditional Chinese Medicine. The α-pinene is a natural compound isolated from pine needle oil which has been shown anti-cancer activity. In previous study, we found that pine needle oil exhibited significant inhibitory effect on hepatoma carcinoma BEL-7402 cells. In this study, we investigate the inhibition of α-pinene on hepatoma carcinoma BEL-7402 cells in vitro and in vivo and further explore the mechanism. The results show that liver cancer cell growth was inhibited obviously with inhibitory rate of 79.3% in vitro and 69.1% in vivo, Chk1 and Chk2 levels were upregulated, CyclinB, CDC25 and CDK1 levels were downregulated.

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“…ECG is rich in essential oil, and limonene, α‐pinene, and myrcene are its main components, accounting for up to 70% (Li et al., ; Lin, Chen, Tu, & Liu, ). Studies have shown that limonene has anti‐inflammatory effects and can also be used to eliminate phlegm (Wang, ), and α‐pinene has been shown to have antitumor and antioxidant activities and is also an important synthetic raw material (Chen et al., ; Yang, Tang, & Chen, ). Essential oil has aromatic, anti‐inflammatory, antibacterial, and antioxidant effects (Huang, Gu, & Li, ), thus it has important application prospects in the pharmaceutical industry and for the preparation of spices and flavorings.…”

Section: Introductionmentioning

confidence: 99%

Inclusion Complex of Exocarpium Citri Grandis Essential Oil with β‐Cyclodextrin: Characterization, Stability, and Antioxidant Activity

Qin

Zhang

et al. 2019

Journal of Food Science

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The purpose of this study was to produce and characterize an inclusion complex between β‐cyclodextrin (β‐CD) and Exocarpium Citri Grandis essential oil (EEO), and to evaluate its antioxidant properties. The volatile compounds of EEO were characterized by gas chromatography‐mass spectrometer. A comparison of the β‐CD, EEO, and the physical mixture with the inclusion complex revealed differences in their thermal stabilities and morphologies, which confirmed the formation of the β‐CD‐EEO inclusion complex. Complexed with β‐CD, the β‐CD‐EEO inclusion complex showed a higher stability and antioxidant activity when compared with physical mixture and EEO. Therefore, β‐CD can be used to form inclusion complexes with EEO to expand its potential applications in the food and drug industries. Practical Application Exocarpium Citri Grandis is rich in essential oil and other ingredients. The optimized extraction, constituent composition, and encapsulation of EEO in β‐CD were investigated in this study. The results showed that the encapsulation process increased the antioxidant activity and stability of EEO, which provides both fundamental and practical knowledge for the application of EEO in the food and drug industries.

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Inhibitory Effects of α-Pinene on Hepatoma Carcinoma Cell Proliferation

Cited by 38 publications

References 15 publications

Natural Compounds as Modulators of Cell Cycle Arrest: Application for Anticancer Chemotherapies

Natural Compounds as Modulators of Cell Cycle Arrest: Application for Anticancer Chemotherapies

Anti-tumor effect of α-pinene on human hepatoma cell lines through inducing G2/M cell cycle arrest

Inclusion Complex of Exocarpium Citri Grandis Essential Oil with β‐Cyclodextrin: Characterization, Stability, and Antioxidant Activity

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