Inhibitory effects of β-caryophyllene on Streptococcus mutans biofilm

Yoo, Hyun-Jun; Jwa, Su-Kyung

doi:10.1016/j.archoralbio.2018.01.009

Cited by 67 publications

(35 citation statements)

References 19 publications

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“…BCP has antimicrobial activity both against Gram-positive bacteria, such as Staphilococcus aureus and Gram-negative bacteria, including Escherichia coli [59]. It is more effective against Gram-positive and the activity of Artemisia fed dei extracts, containing BCP, against bacteria responsible for tooth decay and periodontitis has been reported [60].…”

Section: β-Caryophyllene and Micro-organismsmentioning

confidence: 99%

β-Caryophyllene: A Sesquiterpene with Countless Biological Properties

et al. 2019

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β-Caryophyllene (BCP), a natural bicyclic sesquiterpene, is a selective phytocannabinoid agonist of type 2 receptors (CB2-R). It isn’t psychogenic due to the absence of an affinity to cannabinoid receptor type 1 (CB1). Among the various biological activities, BCP exerts anti-inflammatory action via inhibiting the main inflammatory mediators, such as inducible nitric oxide synthase (iNOS), Interleukin 1 beta (IL-1β), Interleukin-6 (IL-6), tumor necrosis factor-alfa (TNF-α), nuclear factor kapp a-light-chain-enhancer of activated B cells (NF-κB), cyclooxygenase 1 (COX-1), cyclooxygenase 2 (COX-2). Peroxisome proliferator-activated receptors alpha (PPAR-α) effects are also mediated by the activation of PPAR-α and PPAR-γ receptors. In detail, many studies, in vitro and in vivo, suggest that the treatment with β-caryophyllene improves the phenotype of animals used to model various inflammatory pathologies, such as nervous system diseases (Parkinson’s disease, Alzheimer’s disease, multiple sclerosis, amyotrophic lateral sclerosis, stroke), atherosclerosis, and tumours (colon, breast, pancreas, lymphoma, melanoma and glioma cancer). Furthermore, pre-clinical data have highlighted that BCP is potentially useful in Streptococcus infections, osteoporosis, steatohepatitis, and exerts anticonvulsant, analgesic, myorelaxing, sedative, and antidepressive effects. BCP is non-toxic in rodents, with a Lethal dose, 50% (LD50) greater than 5000 mg/kg. Nevertheless, it inhibits various cytochrome P450 isoforms (above all, CYP3A4), which metabolise xenobiotics, leading to adverse effects, due to drug levels over therapeutic window. All the reported data have highlighted that both pharmacological and toxicological aspects need to be further investigated with clinical trials.

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Section: β-Caryophyllene and Micro-organismsmentioning

confidence: 99%

β-Caryophyllene: A Sesquiterpene with Countless Biological Properties

et al. 2019

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“…In case of EOG, the major components with set antimicrobial activity are cymene against Bacillus cereus [30]; D-limonene had a high inhibitory effect on the growth of E. coli, S. aureus, B. subtilis, S. cerevisiae [31]; 1,8-cineole against A. carbonarius [32]; γ-terpinene had significant antibacterial activity against X. oryzaepv. oryzae [33]; linalool [34,35]; camphor against S. epidermidis, E. faecalis and S. aureus [36]; terpinen-4-ol showed antifungal activity against strains of C. posadasii, H. capsulatum and H. capsulatum [37]; β-caryophyllene inhibited the growth of S. mutans [38]. For other species of Gnaphalium genus the antibacterial activity was also shown [11,13].…”

Section: Resultsmentioning

confidence: 96%

Phytochemical Contents, Antimicrobial and Antioxidant Properties of Gnaphalium uliginosum L. Ethanolic Extract and Essential Oil for Agricultural Uses

et al. 2019

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Gnaphalium uliginosum L. (Asteraceae) is widely used in phytotherapy and has a potential for agricultural utilization. The ethanolic extract was obtained from the maceration of air-dried plants, and the extract was then filtered and concentrated using a rotary evaporator. The essential oil was pressed from freshly harvested and crushed, aerial part of plants. The chemical compositions of ethanolic extract and essential oil of G. uliginosum L. (EOG) were investigated using gas chromatography/mass spectrometry (GC/MS). Nine constituents accounted for 77.3 % of the total detected components were determined at the ethanolic extract with a high proportion of sterols 42.8%, fatty acids 24.1 %, triterpenes 14.4 %. Twenty constituents were identified in essential oil of G. uliginosum L.; with α-pinene and estragole accounting for 54.0 %. The ethanolic extract was found to have a moderate antimicrobial activity (MIC values varied from 125 to 500 μg/mL), for S. aureus, B. cereus and A. solani significant activity (less than 62.5 μg/mL). The essential oil was found to have a moderate (MICs 500-1000 μg/mL) and strong activities (31.3-250 μg/mL). The antioxidant activity was evaluated using chemiluminescent assay. The ethanolic extract of G. uliginosum L. acted as a medium-strength antioxidant at concentrations of less than 0.1 mg/mL. The essential oil made be regarded as a weak strength antioxidant.

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“…Other phytochemical presented in the clove ethanolic extract, such as caryophyllene is thus likely to play a role against S. mutans. 31,32 This active phytochemical may act together with eugenol to produce a synergistic action against S. mutans. 33 The antibacterial activity of eugenol against S. mutans was evidenced with the MIC and MBC of 100 and 200 µg/mL, respectively.…”

Section: Discussionmentioning

confidence: 99%

Effects of the Ethanolic Extracts of Guava Leaves, Licorice Roots and Cloves on the Cariogenic Properties of Streptococcus mutans

Phaiboon¹,

Pulbutr²,

Sungthong³

et al. 2019

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Introduction: Streptococcus mutans is a major causative pathogen of dental caries. This study aimed to investigate the effects of the ethanolic extracts of Psidium guajava, Glycyrrhiza glabra and Syzygium aromaticum against cariogenic properties of Streptococcus mutans. These medicinal plants have been used traditionally as the ingredients in the herbal mouthwash for the management of dental caries. Methods: The 95% ethanolic extracts of these medicinal plants were prepared and their phytochemical contents were analyzed by using thin layer chromatography-densitometry. Antibacterial activities of the extracts against S. mutans were evaluated according to broth dilution method. The effects of the extracts against cariogenic properties of S. mutans, which are surface adherence, biofilm formation and acid production, were also investigated. Results: The biological active constituents, quercetin, glycyrrhizic acid and eugenol, were found in P. guajava, G. glabra and S. aromaticum, respectively. The three extracts possessed anti-bacterial activity against S. mutans with the MICs of 1.562, 0.195 and 1.562 mg/mL, respectively. The extracts at every concentration tested (at lower than their MICs) significantly inhibited cariogenic properties of S. mutans, which included inhibitions against surface adherence, biofilm formation and acid production. Conclusions: The ethanolic extracts of guava leaves, licorice roots and cloves produced anti-bacterial and anti-cariogenic activities against S. mutans. These plant extracts thus can potentially be developed as a product for the prevention of dental caries in the near future.

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Inhibitory effects of β-caryophyllene on Streptococcus mutans biofilm

Cited by 67 publications

References 19 publications

β-Caryophyllene: A Sesquiterpene with Countless Biological Properties

β-Caryophyllene: A Sesquiterpene with Countless Biological Properties

Phytochemical Contents, Antimicrobial and Antioxidant Properties of Gnaphalium uliginosum L. Ethanolic Extract and Essential Oil for Agricultural Uses

Effects of the Ethanolic Extracts of Guava Leaves, Licorice Roots and Cloves on the Cariogenic Properties of Streptococcus mutans

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