Inhibitory mechanisms of Agaricus blazei Murill on the growth of prostate cancer in vitro and in vivo

Yu, Ching Han; Kan, Shu; Shu, Chin Hang; Lu, Ting; Sun-Hwang, Lucy; Wang, Paulus S.

doi:10.1016/j.jnutbio.2008.07.004

Cited by 58 publications

(35 citation statements)

References 36 publications

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“…Caspase-7, an apoptosis-related cysteine peptidase, is encoded by the CASP-7 gene located at chromosome 10q25.1-10q25.2 (Teixeira et al, 2008). Caspase-3 and caspase-7 are executioner caspases (Yu et al, 2009). Caspase-3 plays a central role in the execution phase of cell apoptosis, cleaving and activating caspases 6, 7, and 9 (Lakhani et al, 2006).…”

Section: Introductionmentioning

confidence: 99%

HuGE systematic review and meta-analysis demonstrate association of CASP-3 and CASP-7 genetic polymorphisms with cancer risk

Yan¹,

Li²,

Zhu³

et al. 2013

Genet. Mol. Res.

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ABSTRACT. Genetic variations in the caspase genes CASP-3 and CASP-7 are known to be involved in apoptosis, cytokine maturation, cell growth and differentiation. Polymorphisms of CASP-3 and CASP-7 genes have been increasingly recognized as important regulators in the development of cancer. However, whether there is a specific association is still controversial. Therefore, we made a Human Genome Epidemiology review and meta-analysis to explore the association between polymorphisms of CASP-3 and CASP-7 genes and cancer risk. Based on the inclusion criteria, we examined 9 case-control studies, with a total of 3142 cancer cases and 3670 healthy controls. Meta-analysis results showed that the homozygote (CC) of rs2705897 in the CASP-3 gene is positively associated with cancer susceptibility [odds ratio (OR) = 4.36, 95% confidence interval (CI) = 1.26-15.11, P = 0.02], while the C allele and C carrier (TC+CC) of rs1049216 are negatively associated with cancer risk (OR = 0.81, 95%CI = 0.69-0.95, P = 0.01; OR = 0.78, 95%CI= 0.63-0.97, P = 0.02, respectively). The G allele and G carrier of rs4647603 (A/G) in CASP-3 had positive associations with cancer susceptibility (OR = 1.69, 95%CI = 1.37-2.09, P < 0.001; OR = 1.93, 95%CI = 1.26-2.93, P = 0.002, respectively). The T allele of rs12415607, the G allele and homozygote (GG) of rs2227310, and homozygote (CC) of rs3124740 also had positive associations with cancer risk (OR = 1.18, 95%CI = 1.02-1.37, P = 0.03; OR = 1.17, 95%CI = 1.01-1.34, P = 0.03; OR = 1.34, 95%CI = 1.04-1.74, P = 0.03; OR = 1.30, 95%CI = 1.04-1.63, P = 0.02, respectively). In addition, homozygote (AA) of rs11196418 showed a significant negative association with cancer risk (OR = 0.36, 95%CI = 0.14-0.93, P = 0.03). These meta-analysis results demonstrated that CASP-3 and CASP-7 genetic polymorphisms are involved in the pathogenesis of cancer.

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Section: Introductionmentioning

confidence: 99%

HuGE systematic review and meta-analysis demonstrate association of CASP-3 and CASP-7 genetic polymorphisms with cancer risk

Yan¹,

Li²,

Zhu³

et al. 2013

Genet. Mol. Res.

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“…As seen in Fig. 1A, increased concentration of MC (0-0.5 mg/ml) markedly suppressed proliferation of (11,18,19,26,50,67) induced apoptosis in a variety of cancer cells. Therefore, the mixture of medicinal mushrooms in MC can diminish the cytotoxic or pro-apoptotic effect of the individual mushroom.…”

Section: Demonstrates Cytostatic Effect On the Highly Invasive Brementioning

confidence: 70%

“…The polysaccharide phytocomplex was suggested to be responsible for the immunostimulant and anti-tumor properties of A. blazei, probably through an opsonizing biochemical pathway (10). In addition, recent studies demonstrated anticancer activities of A. blazei through the induction of apoptosis by the activation of caspase-3 in prostate cancer cells (11) and inhibition of constitutively active NF-κB in leukemic cells (12). Moreover, A. blazei demonstrated anti-metastatic effect through the inhibition of MMP-9 in melanoma cells (13).…”

Section: Introductionmentioning

confidence: 99%

Novel medicinal mushroom blend suppresses growth and invasiveness of human breast cancer cells

Jiang

Slíva²

2010

Int J Oncol

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Abstract. Mushrooms are an integral part of Traditional Chinese Medicine (TCM), and have been used for millennia to prevent or treat a variety of diseases. Currently mushrooms or their extracts are used globally in the form of dietary supplements. In the present study we have evaluated the anticancer effects of the dietary supplement, MycoPhyto ® Complex (MC), a novel medicinal mushroom blend which consists of a blend of mushroom mycelia from the species Agaricus blazei, Cordyceps sinensis, Coriolus versicolor, Ganoderma lucidum, Grifola frondosa and Polyporus umbellatus, and ß-1,3-glucan isolated from the yeast, Saccharomyces cerevisiae. Here, we show that MC demonstrates cytostatic effects through the inhibition of cell proliferation and cell cycle arrest at the G2/M phase of highly invasive human breast cancer cells MDA-MB-231. DNA-microarray analysis revealed that MC inhibits expression of cell cycle regulatory genes (ANAPC2, ANAPC2, BIRC5, Cyclin B1, Cyclin H, CDC20, CDK2, CKS1B, Cullin 1, E2F1, KPNA2, PKMYT1 and TFDP1). Moreover, MC also suppresses the metastatic behavior of MDA-MB-231 by the inhibition of cell adhesion, cell migration and cell invasion. The potency of MC to inhibit invasiveness of breast cancer cells is linked to the suppression of secretion of the urokinase plasminogen activator (uPA) from MDA-MB-231 cells. In conclusion, the MC dietary supplement could have potential therapeutic value in the treatment of invasive human breast cancer.

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“…Trabalhos têm relatado que o AbM apresenta atividade antibacteriana, como, por exemplo, na avaliação in vitro contra agentes patogênicos orais para humanos, tais como Streptococcus mutans (Lund et al, 2009), além de atividade antioxidante (Soares et al, 2009), antidiabética (Kim et al, 2005), forte atividade imunoestimulante (Yuminamochi et al, 2007), bem como efeitos antitumorais e anticâncer (Yu et al, 2009), entre outros.…”

Section: Palavras-chaveunclassified

Efeito da extração de compostos fenólicos sobre a atividade antioxidante e antibacteriana in vitro de cogumelo-do-sol

et al. 2016

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RESUMO: O cogumelo-do-sol (Agaricus blazei Murril) é amplamente consumido, por conta de suas propriedades medicinais. Este estudo teve como objetivo determinar a atividade antioxidante e antibacteriana in vitro dos extratos de cogumelo do sol, mediante diferentes tempos e temperaturas de extração. As amostras foram analisadas quanto à composição centesimal, determinação do teor de fenólicos totais e atividade antioxidante e antibacteriana in vitro. Os resultados demonstram que esse tipo de cogumelo aparece como um agente antioxidante potencial, obtendo-se melhores resultados na temperatura de 70ºC durante 60 minutos de extração hidroetanólica. Esse extrato não aponta atividade antibacteriana para os micro-organismos em teste.

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Inhibitory mechanisms of Agaricus blazei Murill on the growth of prostate cancer in vitro and in vivo

Cited by 58 publications

References 36 publications

HuGE systematic review and meta-analysis demonstrate association of CASP-3 and CASP-7 genetic polymorphisms with cancer risk

HuGE systematic review and meta-analysis demonstrate association of CASP-3 and CASP-7 genetic polymorphisms with cancer risk

Novel medicinal mushroom blend suppresses growth and invasiveness of human breast cancer cells

Efeito da extração de compostos fenólicos sobre a atividade antioxidante e antibacteriana in vitro de cogumelo-do-sol

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