Inhibitory NANC neurotransmission in choledocho–duodenal junction of rabbits—a possible role of PACAP

Imoto, Akihiko; Inoue, Ryuji; Tanaka, Masao; Ito, Yushi

doi:10.1016/s0165-1838(98)00051-4

Cited by 38 publications

(13 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…All patients (n = 42) fulfilled the following diagnostic criteria for probable MSA [5]: (1) progressive cerebellar ataxia and/or non- or poorly levodopa-responsive parkinsonism without evidence of a focal or nonfocal symptomatic origin of the disorder; (2) severe symptomatic autonomic failure with orthostatic hypotension and/or urinary incontinence not due to other causes; (3) absence of any neurodegenerative disorders in relatives and no evidence of consanguinity of parents, and (4) absence of dementia according to DSM-III-R (Diagnostic and Statistical Manual of Psychiatry, 1987) criteria, focal cortical dysfunction or predominant downgaze supranuclear palsy. Based on their clinical presentation, patients were subdivided into a group with predominant cerebellar symptoms (MSA-C, n = 28) at disease onset and another with predominant parkinsonian presentation (MSA-P, n = 14).…”

Section: Methodsmentioning

confidence: 99%

Nerve Conduction Studies in Multiple System Atrophy

et al. 2000

View full text Add to dashboard Cite

To study the frequency and severity of peripheral neuropathy in multiple system atrophy (MSA), we performed nerve conduction studies in 42 MSA patients suffering from either cerebellar MSA (MSA-C) or parkinsonian MSA (MSA-P). Abnormal nerve conduction was present in 24% of the patients. Abnormalities were significantly more frequent in MSA-P (43%) compared to MSA-C (14%). Motor nerve conduction velocities were reduced in 4% of the MSA-C and in 7% of the MSA-P patients. Abnormal compound muscle action potentials were more frequent in MSA-P (29% versus 7% in MSA-C) pointing to a more pronounced loss of motor axons in this subgroup. Sensory nerve conduction velocities were abnormal in 4% of the MSA-C and 14% of the MSA-P patients, and mean sensory nerve action potentials were normal in all MSA-C and reduced in 7% of the MSA-P patients. The data provide evidence that the peripheral nervous system is differentially affected in MSA-C and MSA-P.

show abstract

Section: Methodsmentioning

confidence: 99%

Nerve Conduction Studies in Multiple System Atrophy

et al. 2000

View full text Add to dashboard Cite

show abstract

“…Interestingly, we found that exogenous ATP also affects inhibitory neural pathways, involving nicotinic receptors and nitrergic nerves. In support of the presence of an inhibitory purinergic pathway in SO, an electrophysiological study using rabbit SO found ATP acting via P2X receptors, together with PACAP, to be involved in the NANC inhibitory junction potential [14].…”

Section: Discussionmentioning

confidence: 98%

“…Exogenous application of adenosine triphosphate (ATP) in vitro induced a relaxation in rabbit SO [10], inhibited spontaneous activity in cat SO [11], induced a noncholinergic contractile response in guinea pig SO [12], or had no effect in human SO [13]. Further electrophysiological investigations found desensitization of P2X receptors suppressed the nonadrenergic, noncholinergic (NANC) inhibitory junction potential, suggesting ATP was a transmitter involved in the NANC relaxation of rabbit SO [14]. A recent in vitro study using possum SO muscle rings found exogenous ATP induced a neurally mediated excitation followed by a tetrodotoxin (TTX)-insensitive inhibition of spontaneous contractions [15].…”

Section: Introductionmentioning

confidence: 99%

Exogenous Adenosine Triphosphate and Adenosine Stimulate Proximal Sphincter of Oddi Motility Via Neural Mechanisms in the Anesthetized Australian Possum

2006

View full text Add to dashboard Cite

We aimed to determine if exogenous adenosine triphosphate or adenosine modulated sphincter of Oddi motility and involved neural mechanisms. Sphincter of Oddi motility was recorded in anesthetized possums by manometry. Adenosine triphosphate or adenosine (1 microM-10 mM) was applied topically to the sphincter before and after pretreatment with tetrodotoxin, hexamethonium, atropine, or Nomega-nitro-L-arginine methyl ester. Sphincter contraction amplitude and frequency were quantified. Adenosine triphosphate induced a concentration-dependent increase in proximal sphincter contraction amplitude and frequency (P < 0.05). This response was reduced by tetrodotoxin and atropine but enhanced by hexamethonium and Nomega-nitro-L-arginine methyl ester. Adenosine concentration dependently increased proximal sphincter contraction amplitude (P < 0.05) only. This response was reduced by tetrodotoxin, atropine, and Nomega-nitro-L-arginine methyl ester, whereas hexamethonium had no effect. We conclude that exogenous adenosine triphosphate and adenosine stimulate proximal sphincter of Oddi motility via neural mechanisms, involving cholinergic motor neurons. Adenosine triphosphate may further modulate sphincter motility via nicotinic and nitrergic pathways.

show abstract

“…However in molluscs there are muscles (e.g. posterior jugalis, columellar and buccal retractor muscles of Helisoma) where no evidence for multineuronal innervation of individual muscle fibers was observed [40].…”

Section: Innervationmentioning

confidence: 99%

“…In vertebrates PACAP modulates the effects of transmitters at inhibitory smooth muscle neuromuscular junctions, where it elicits relaxation by increasing adenylate cyclase activity or by controlling smooth muscle mechanical activity. It acts directly on muscle cells via PACAP receptors or indirectly by stimulating NO synthesis [40,61,90,104]. In order to determine whether the effect of PACAP was elicited through pre-and/or postsynaptic mechanisms on the FMs, the localization of PACAP and its receptors was assessed by immunohistochemistry.…”

Section: Synaptic Modulation Is Crucial For Spatial and Temporal Collmentioning

confidence: 99%

Anatomical and physiological background permitting spatial odor sensation in stylommatophoran molluscs

Kiss

Krajcs

2016

Acta Biologica Hungarica

View full text Add to dashboard Cite

Earlier experiments demonstrated that in order to place protracted tentacles and thereby olfactory receptors in an appropriate position for optimal perception of odor stimuli extraordinary complex movements are required. Until recently both large scale tentacle movements and patterned tentacle movements have been attributed to the concerted involvement of the tentacle retractor muscle and muscles of tegumentum. Recently the existence of three novel muscles in the posterior tentacles of Helix has been discovered. The present review, based on experimental data obtained by our research group, outlines the anatomy, physiology and pharmacology of these muscles that enable the tentacles to execute complex movements observed during foraging both in naïve and food-conditioned snails. Our findings are also compared as far as possible with earlier and recent data obtained on innervation characteristics and pharmacology of molluscan muscles.

show abstract

Inhibitory NANC neurotransmission in choledocho–duodenal junction of rabbits—a possible role of PACAP

Cited by 38 publications

References 21 publications

Nerve Conduction Studies in Multiple System Atrophy

Nerve Conduction Studies in Multiple System Atrophy

Exogenous Adenosine Triphosphate and Adenosine Stimulate Proximal Sphincter of Oddi Motility Via Neural Mechanisms in the Anesthetized Australian Possum

Anatomical and physiological background permitting spatial odor sensation in stylommatophoran molluscs

Contact Info

Product

Resources

About