Inhibitory receptive fields of primate spinothalamic tract cells

Gerhart, K. D.; Yezierski, Robert P.; Giesler, Glenn J.; Willis, William D.

doi:10.1152/jn.1981.46.6.1309

Cited by 122 publications

(21 citation statements)

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“…At the spinal level, spatially remote noxious stimuli have long been known to inhibit the activity of neurons in the dorsal horn of the spinal cord [1,31,9,19]. The activity of spinothalamic tract neurons can be inhibited by noxious stimulation of remote body areas and this inhibition remains even after spinal cord transaction [9,19].…”

Section: Discussionmentioning

confidence: 99%

“…The activity of spinothalamic tract neurons can be inhibited by noxious stimulation of remote body areas and this inhibition remains even after spinal cord transaction [9,19]. It is important to note that DNIC is distinct from heterotopic stimulation induced inhibition which is mediated by local circuits within the spinal cord because DNIC necessarily involves activation of descending inhibition from the brainstem [17].…”

Section: Discussionmentioning

confidence: 99%

“…This ‘pain inhibits pain’ phenomenon is suggested to involve a spatial filtering of pain that helps to extract nociceptive signals from the background noise [18]. Similar spatial regulation of nociceptive processing can also be accomplished solely at the spinal level without recruitment of descending inhibition [9]. Both forms of heterotopic inhibition are measured psychophysically in the laboratory by the conditioned pain modulation (CPM) paradigm [39].…”

Section: Introductionmentioning

confidence: 99%

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Distinct brain mechanisms support spatial vs temporal filtering of nociceptive information

Nahman‐Averbuch

Martucci

Granovsky

et al. 2014

Pain

100

117

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The role of endogenous analgesic mechanisms has largely been viewed in the context of gain modulation during nociceptive processing. However, these analgesic mechanisms may play critical roles in the extraction and subsequent utilization of information related to spatial and temporal features of nociceptive input. To date, it remains unknown if spatial and temporal filtering of nociceptive information is supported by similar analgesic mechanisms. To address this question, human volunteers were recruited to assess brain activation with functional MRI during conditioned pain modulation (CPM) and offset analgesia (OA). CPM provides one paradigm for assessing spatial filtering of nociceptive information while OA provides a paradigm for assessing temporal filtering of nociceptive information. CPM and OA both produced statistically significant reductions in pain intensity. However, the magnitude of pain reduction elicited by CPM was not correlated with that elicited by OA across different individuals. Different patterns of brain activation were consistent with the psychophysical findings. CPM elicited widespread reductions in regions engaged in nociceptive processing such as the thalamus, insula and SII. OA produced reduced activity in SI, but was associated with greater activation in the anterior insula, dorso-lateral prefrontal cortex, intra-parietal sulcus, and inferior parietal lobule relative to CPM. In the brainstem, CPM consistently produced reductions in activity while OA produced increases in activity. Conjunction analysis confirmed that CPM related activity did not overlap with that of OA. Thus, dissociable mechanisms support inhibitory processes engaged during spatial vs. temporal filtering of nociceptive information.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Distinct brain mechanisms support spatial vs temporal filtering of nociceptive information

Nahman‐Averbuch

Martucci

Granovsky

et al. 2014

Pain

100

117

View full text Add to dashboard Cite

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“…It is interesting to note that STT cells often have both excitatory and inhibitory receptive fields [16]. For example, the receptive fields of an STT cell are shown in figure 4B.…”

Section: Stimulation In Pag or Nrm Inhibits Stt Cellsmentioning

confidence: 99%

“…Squeezing the skin produced an ex citation from one foot but comparable stimulation over the remainder of the surface of the body and face resulted in an inhibition [35]. Part of the neural mechanism of this inhibition depends upon spinal cord cir cuits, but part appears to depend upon a loop through the brain stem, perhaps through the NRM and adjacent reticular formation [16,24,25]. These results by no means prove that the raphe-and reticulospinal neurons from which we recorded in fact inhibited STT cells or that this system in fact operates as an antinociceptive pathway.…”

Section: Stimulation In Pag or Nrm Inhibits Stt Cellsmentioning

confidence: 99%

Central Nervous System Mechanisms for Pain Modulation

Willis¹

1985

Stereotact Funct Neurosurg

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Although a great deal has been learned about the neural basis for stimulation-produced analgesia, it is evident that the ‘analgesia systems’ are much more complex than was initially thought. Part of the complexity derives from the fact that a number of different pathways, using several different neurotransmitters, can affect nociceptive transmission. Further complexity sterns from evidence that nociceptive transmission can be modulated both at a spinal cord level and at higher levels of the nociceptive projection system, such as the thalamus. Hopefully, a greater understanding of the ‘analgesia system’ will lead to explanations for a number of puzzling aspects of pain and perhaps to improved therapy.

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GABA‐immunoreactive terminals synapse on primate spinothalamic tract cells

Carlton

Westlund

Zhang

et al. 1992

J of Comparative Neurology

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Gamma-aminobutyric acid (GABA) is a putative inhibitory neurotransmitter in the vertebrate nervous system. Several lines of evidence suggest that GABA plays an important role in the processing and modulation of sensory input in the spinal cord dorsal horn. In the present study, the relationship between GABA-immunoreactive (GABA-IR) terminals and spinothalamic tract (STT) cells in the monkey lumbar cord was investigated. Physiologically characterized STT cells, one located in lamina V and two located in lateral lamina IV, were intracellularly injected with horseradish peroxidase (HRP). A fourth STT cell, located in lamina I, was retrogradely labeled following injection of HRP into the contralateral thalamus. Immunogold labeling of ultrathin sections through the cell bodies and proximal dendrites of the STT neurons demonstrated that the percentage of the GABA-IR terminals in contact with these profiles was 24.7% and 36%, respectively. The average STT surface length contacted by GABA-IR terminals for cell bodies and proximal dendrites was 18.2% and 26.7%, respectively. For the lamina I cell, 7 out of 35 (20%) of the terminals were GABA-IR and they covered 9.6% of the surface analyzed. These data demonstrate that GABA-IR terminals synapse directly on STT cells, constituting a substantial proportion of the terminal population on these cells. Furthermore, compared to the cell bodies, a greater percentage of the input on the proximal dendrites is GABAergic. These anatomical data are consistent with the findings of a previously published iontophoretic study that demonstrated that GABA can exert a strong inhibitory influence on STT cells. These findings are discussed in relation to GABAergic involvement in tonic and phasic inhibition of STT neurons.

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Inhibitory receptive fields of primate spinothalamic tract cells

Cited by 122 publications

References 0 publications

Distinct brain mechanisms support spatial vs temporal filtering of nociceptive information

Distinct brain mechanisms support spatial vs temporal filtering of nociceptive information

Central Nervous System Mechanisms for Pain Modulation

GABA‐immunoreactive terminals synapse on primate spinothalamic tract cells

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