Purpose: To optimize the Rosette trajectories for fast, high sensitivity spectroscopic imaging experiments and to compare this acquisition technique with other chemical shift imaging (CSI) methods.
Materials and Methods:A framework for comparing the sensitivity of the Rosette Spectroscopic Imaging (RSI) acquisition to other spectroscopic imaging experiments is outlined. Accounting for hardware constraints, trajectory parameters that provide for optimal sampling and minimal artifact production are found. Along with an analytical expression for the number of excitations to be used in an RSI experiment that is provided, the theoretical precompensation weights used for optimal image reconstruction are derived.
Results:The spectral response function for RSI is shown to be approximately the same as the point spread function of standard Fourier reconstructions. While the signal-tonoise ratio (SNR) for an RSI experiment is reduced by the inherent nonuniform sampling of these trajectories, their circular k-space support and speed of spatial encoding leads to greater SNR efficiency and improvements in the total data acquisition time relative to the gold standard CSI approach with square k-space support and to similar efficiency to spiral CSI acquisitions. Numerical simulations and in vivo experimental data are presented to demonstrate the properties of this data acquisition technique.
Conclusion:This work demonstrates the use of Rosette trajectories and how to achieve improved efficiency for these trajectories in a two-dimensional spectroscopic imaging experiment. CHEMICAL SHIFT IMAGING (CSI; 1) has been the mainstay of MR spectroscopic imaging because of its simple implementation, reliability, and ease of image reconstruction. This technique has been widely used for observing the changes in the metabolic signature of tissues during evolving pathological and/or physiological conditions. CSI owes its ease of implementation and analysis to the Fourier encoding approach upon which is based. In this approach, the spectral-spatial information is encoded in a rectilinear manner that favors the acquisition of very high-resolution information along the spectral axis and relatively low resolution along the spatial directions. Several fast CSI sequences, mostly using Cartesian trajectories, have been introduced to reduce the long experimental duration associated with this method. However, an extensive theoretical study (2) found their SNR efficiency to be lower than the one for standard CSI. For applications where higher spatial resolution is desired over a narrower spectral bandwidth, trajectory designs that cover a disk in kspace, periodically sampling its center and circular edge, using time-dependent gradients with readouts as long as the CSI readout, offer a convenient means to achieve significant speedups in data acquisition while maintaining adequate SNR efficiency. This stems from the fact that the readout period could be used to acquire multiple spatial frequency values which, in turn, leads to a reduction in the total num...