Initial assessment of suitability of MCF-7 and HepG2 cancer cell lines for AQP3 research in cancer biology

Oberska, Patrycja; Jędrzejczak-Silicka, Magdalena; Michałek, Katarzyna; Grabowska, Marta

doi:10.1016/j.acthis.2021.151716

Cited by 2 publications

(1 citation statement)

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“…The expression patterns and subcellular localization of AQP3 are specific to different cell types and have been associated with cancer cell aggressiveness and mobility [41]. As a peroxiporin, AQP3 facilitates the transport of hydrogen peroxide and subsequently diverse signaling pathways.…”

Section: Aqp3mentioning

confidence: 99%

The Involvement of Peroxiporins and Antioxidant Transcription Factors in Breast Cancer Therapy Resistance

Milković,

Mlinarić,

Lučić

et al. 2023

Cancers

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Breast cancer is still the leading cause of death in women of all ages. The reason for this is therapy resistance, which leads to the progression of the disease and the formation of metastases. Multidrug resistance (MDR) is a multifactorial process that leads to therapy failure. MDR involves multiple processes and many signaling pathways that support each other, making it difficult to overcome once established. Here, we discuss cellular-oxidative-stress-modulating factors focusing on transcription factors NRF2, FOXO family, and peroxiporins, as well as their possible contribution to MDR. This is significant because oxidative stress is a consequence of radiotherapy, chemotherapy, and immunotherapy, and the activation of detoxification pathways could modulate the cellular response to therapy and could support MDR. These proteins are not directly responsible for MDR, but they support the survival of cancer cells under stress conditions.

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Section: Aqp3mentioning

confidence: 99%