Initial changes in alveolar bone volume for sham-operated and ovariectomized rats in ligature-induced experimental periodontitis

Dai, Jing; Ma, Yang; Shi, Miusi; Cao, Zhengguo; Zhang, Yufeng; Miron, Richard J.

doi:10.1007/s00784-015-1531-3

Cited by 24 publications

(25 citation statements)

References 32 publications

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“…EP as expected induced alveolar bone loss, and the combination EP + OVX aggravated the deterioration in alveolar bone microarchitecture compared to mice with EP alone, as shown by a significantly lower BV/TV around the first molar, in agreement with other studies in rats [43] and mice [44]. These results suggest that estrogen deficiency can exacerbate the severity of alveolar bone deterioration, via mechanisms to be identified.…”

Section: Discussionsupporting

confidence: 89%

Periodontal disease exacerbates systemic ovariectomy-induced bone loss in mice

Anbinder

Moraes

Lima

et al. 2016

Bone

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Periodontal pathogens and/or inflammatory products from periodontitis participate in the development or progression of systemic diseases. In this context, periodontitis acts as a modifying factor to systemic health, including diabetes and cardiovascular diseases. Osteoporosis is an increasingly prevalent condition in our aging population and considered a risk factor for periodontal disease, but the effect of periodontitis on systemic bone homeostasis is unknown. We thus evaluated the effects of experimental periodontitis (EP) on systemic bone loss and the influence of estrogen deficiency in this context, using a mouse model of combined periodontitis and osteoporosis. Experimental periodontitis (EP) was induced by a ligature insertion around the mandibular first molars and Porphyromonas gingivalis infection. Three-dimensional microcomputed tomographic analyses performed 48days following infection revealed that EP and ovariectomy (OVX) induced a significantly higher femoral and mandibular bone loss compared to EP or OVX alone. EP alone did not induce systemic bone loss. In addition, the EP+OVX and EP groups showed significantly higher levels of tumor necrosis factor (TNF)-α than OVX and control groups at end point. These results suggest that periodontitis could be a risk factor for systemic bone loss, especially in post-menopausal women, and warrant further clinical investigations to confirm this association and propose adapted prophylactic and curative therapies.

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Section: Discussionsupporting

confidence: 89%

Periodontal disease exacerbates systemic ovariectomy-induced bone loss in mice

Anbinder

Moraes

Lima

et al. 2016

Bone

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“…The material was then routinely processed, and histological sections (5 um) were made of the buccal surface of the mandibles, which were stained with haematoxylin and eosin as described by Dai et al. (). The slides were then photographed (4x) using a capture system and image analysis, consisting of a Olympus CX31 binocular microscope (Olympus Optical do Brazil Ltda, São Paulo, SP, Brazil) with an attached camera (SC30 CMOS Color Camera for Light Microscopy, Olympus Optical do Brazil Ltda, São Paulo, SP, Brazil).…”

Section: Methodsmentioning

confidence: 99%

Exercise attenuates alveolar bone loss and anxiety‐like behaviour in rats with periodontitis

Andrade

Orlando

Gomes

et al. 2017

J Clinic Periodontology

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“…Experimental periodontitis in animal models has been shown to induce liver damage . A link between periodontitis, oral and gut dysbiosis, and gut permeability has also been described .…”

Section: Introductionmentioning

confidence: 99%

“…[15][16][17] Experimental periodontitis in animal models has been shown to induce liver damage. [18][19][20] A link between periodontitis, oral and gut dysbiosis, and gut permeability has also been described. 21 In non-alcoholic fatty liver disease (NAFLD) patients, treatment of periodontitis was associated with a reduction in serum transaminase levels.…”

Section: Introductionmentioning

confidence: 99%

Periodontitis is associated with incident chronic liver disease—A population‐based cohort study

Helenius‐Hietala

Suominen

Ruokonen

et al. 2018

Liver International

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Background & Aims Chronic liver disease is a major health concern worldwide and the identification of novel modifiable risk factors may benefit subjects at risk. Few studies have analyzed periodontitis as a risk factor for liver complications. We studied whether periodontitis is associated with incident severe liver disease. Methods The study comprised 6165 individuals without baseline liver disease who participated in the Finnish population‐based Health 2000 Survey (BRIF8901) during 2000‐2001, a nationally representative cohort. Follow‐up was until 2013 for liver‐related admissions, liver cancer and mortality from National Hospital Discharge, Finnish Cancer Registry and Causes of Death Register, Statistics Finland. Mild to moderate periodontitis was defined as ≥1 tooth with periodontal pocket ≥4 mm deep, and advanced periodontitis as ≥5 teeth with such pockets. Multiple confounders were considered. Results A total of 79 subjects experienced a severe liver event during follow‐up. When adjusted for age, sex and number of teeth, hazards ratios by Cox regression regarding incident severe liver disease were, for mild to moderate periodontitis, 2.12 (95% CI 0.98‐4.58), and, for advanced periodontitis, 3.69 (95% CI 1.79‐7.60). These risk estimates remained stable after additionally adjusting for alcohol use, smoking, metabolic risk, serum gamma‐glutamyltransferase, dental‐care habits, lifestyle and socioeconomic status. Periodontal disease‐associated liver risk was accentuated among subjects with non‐alcoholic fatty liver disease or heavy alcohol use at baseline. Conclusions Periodontitis was associated with incident liver disease in the general population independently of various confounders. As a preventable disease, periodontal disease might present a modifiable risk factor for chronic liver disease.

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Initial changes in alveolar bone volume for sham-operated and ovariectomized rats in ligature-induced experimental periodontitis

Cited by 24 publications

References 32 publications

Periodontal disease exacerbates systemic ovariectomy-induced bone loss in mice

Periodontal disease exacerbates systemic ovariectomy-induced bone loss in mice

Exercise attenuates alveolar bone loss and anxiety‐like behaviour in rats with periodontitis

Periodontitis is associated with incident chronic liver disease—A population‐based cohort study

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