“Initial, Continuous and Intermittent Bolus” Administration of Minimally-Diluted Blood Cardioplegia Supplemented with Potassium and Magnesium for Hypertrophied Hearts

Hayashi, Yoshitaka; Ohtani, Masakatsu; Hiraishi, Taizo; Kobayashi, Yasuhiko; Nakamura, Takayuki

doi:10.1016/j.hlc.2006.06.004

Cited by 13 publications

(13 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Descriptive statistics and summary statistics were calculated for each CP group as count and percentage for categorical variables, mean and standard deviation for continuous and normally-distributed variables or median and interquartile range for heavily skewed continuous variables. 2…”

Section: Methodsmentioning

confidence: 99%

“…The changing acuity of patients undergoing cardiac surgery with cardiopulmonary bypass (CPB) further complicates myocardial protection and technologies have evolved to address a more complex surgical environment. 1–3 While early CP formulations were based on asanguineous solutions, a move towards blood-based formulation occurred over the last several decades, with the most common American delivery solution employing a ratio of four parts blood to one part (4:1) crystalloid. 4…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Does the type of cardioplegia used during valve surgery influence operative nadir hematocrit and transfusion requirements?

et al. 2018

View full text Add to dashboard Cite

show abstract

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Does the type of cardioplegia used during valve surgery influence operative nadir hematocrit and transfusion requirements?

et al. 2018

View full text Add to dashboard Cite

show abstract

“…We used a 5% level of significance and 95% confidence intervals (CIs); figures were produced using CMA. Funnel plots were used to analyse pub- The eleven studies 6,[8][9][10][11][13][14][15][16][17][18] included in the analysis had an aggregate of 5684 participants, 2681 of whom were microplegia patients versus 3003 who received other types of cardioplegia. The characteristics of the included studies are summarized in Table 1.…”

Section: Data Synthesismentioning

confidence: 99%

“…Early clinical trials reported the use of less vasopressors 8 and better postoperative left ventricular function 9 with microplegia. More recent trials have consistently shown a higher establishment of spontaneous heartbeat return using microplegia when compared to standard diluted blood cardioplegia 10,11 . One drawback to these studies was low statistical power suggesting the need for a larger analysis/meta‐analysis to investigate for true differences.…”

Section: Introductionmentioning

confidence: 99%

Microplegia in cardiac surgery: Systematic review and meta‐analysis

et al. 2020

View full text Add to dashboard Cite

Background Consensus on the optimum choice of cardioplegia remains elusive. One possibility that has been suggested to have beneficial properties is microplegia, a cardioplegia of reduced crystalloid volume. The aim of this meta‐analysis is to comprehensively investigate microplegia against a range of clinical outcomes. Methods To identify potential studies, systematic searches were carried out in four databases (eg, Pubmed, EMBASE). The search strategy included the key concepts of “microplegia” OR “mini‐cardioplegia” OR “miniplegia” AND “cardiac surgery.” This was followed by a meta‐analysis investigating: mortality, crystalloid volume; cardiopulmonary bypass time; cross‐clamp time; intra‐aortic balloon pump use; spontaneous heartbeat recovery; inotropic support; low cardiac output syndrome; myocardial infarction; acute renal failure; atrial fibrillation, reoperation for bleeding; creatine kinase myocardial band (CK‐MB); intensive care unit (ICU) time and hospital stay. Results Eleven studies comprising 5798 participants were analyzed. Microplegia used a lower volume of crystalloids and led to a higher spontaneous return of heartbeat, odds ratio (OR) 4.271 (95% confidence intervals [CIs]: 1.935, 9.423; I2 = 76.57%; P < .001) and a lower requirement for inotropic support, OR: 0.665 (95% CI: 0.47, 0.941; I2 = 3.53%; P = .021). Microplegia was also associated with a lower CK‐MB release, mean difference (MD) −6.448 ng/mL (95% CI: −9.386, −3.511; I2 = 0%; P < .001) and a shorter ICU stay, MD: −0.411 days (95% CI: −0.812, −0.009; I2 = 17.65%; P = .045). All other comparisons were nonsignificant. Conclusions Microplegia has similar effects to other types of cardioplegia and is beneficial with regard to spontaneous return of heartbeat, inotropic support, ICU stay, and CK‐MB release.

show abstract

“…Habitually low intake of magnesium induces changes in biochemical pathways that can increase the risk of illness such as hypertension and cardiovascular disease, type 2 diabetes, osteoporosis, and migraine headaches [7]. The important role of magnesium in the etiology of cardiovascular pathology has been pointed out by a considerable number of experimental [8][9][10], epidemiological [11][12][13][14] and clinical studies [15][16][17]. Increased magnesium intake appears to have a favorable influence on heart disease and its risk factors, including diabetes mellitus [18], hypertension [19], and metabolic syndrome [20], but also in heart disease [11].…”

Section: Introductionmentioning

confidence: 99%

Dose-response relationship between dietary magnesium intake and cardiovascular mortality: A systematic review and dose-based meta-regression analysis of prospective studies

Fang

Liang

et al. 2016

Journal of Trace Elements in Medicine and Biology

View full text Add to dashboard Cite

a b s t r a c tBackground: Although epidemiology studies have reported the relationship, including a dose-response relationship, between dietary magnesium intake and risk of cardiovascular disease (CVD), the risk for CVD mortality is inconclusive and the evidence for a dose-response relationship has not been summarized. Objective: We conducted a systematic review and meta-analysis of prospective studies to summarize the evidence regarding the association of dietary magnesium intake with risk of CVD mortality and describe their dose-response relationship. Design: We identified relevant studies by searching major scientific literature databases and grey literature resources from their inception to August 2015, and reviewed references lists of retrieved articles. We included population-based studies that reported mortality risks, i.e. relative risks (RRs), odds ratios (ORs) or hazard ratios (HRs) of CVD mortality or cause-specific CVD death. Linear dose-response relationships were assessed using random-effects meta-regression. Potential nonlinear associations were evaluated using restricted cubic splines. Results: Out of 3002 articles, 9 articles from 8 independent studies met the eligibility criteria. These studies comprised 449,748 individuals and 10,313 CVD deaths. Compared with the lowest dietary magnesium consumption group in the population, the risk of CVD mortality was reduced by 16% in women and 8% in men. No significant linear dose-response relationship was found between increment in dietary magnesium intake and CVD mortality across all the studies. After adjusting for age and BMI, the risk of CVD mortality was reduced by 24-25% per 100 mg/d increment in dietary magnesium intake in women of all the participants and in all the US participants. Conclusion: Although the combined data confirm the role of dietary magnesium intake in reducing CVD mortality, the dose-response relationship was only found among women and in US population.

show abstract

“Initial, Continuous and Intermittent Bolus” Administration of Minimally-Diluted Blood Cardioplegia Supplemented with Potassium and Magnesium for Hypertrophied Hearts

Cited by 13 publications

References 27 publications

Does the type of cardioplegia used during valve surgery influence operative nadir hematocrit and transfusion requirements?

Does the type of cardioplegia used during valve surgery influence operative nadir hematocrit and transfusion requirements?

Microplegia in cardiac surgery: Systematic review and meta‐analysis

Dose-response relationship between dietary magnesium intake and cardiovascular mortality: A systematic review and dose-based meta-regression analysis of prospective studies

Contact Info

Product

Resources

About