Initial Experience With Spect (Single-Photon Computerized Tomography) Ok the Brain Using N-Isopropyl 1–123 P-Iodoamphetamine

Hill, Thomas C.; Holman, B. Leonard; Lovett, Rosemary; O’Leary, Daniel H.; Front, Dov; Magistretti, Philippe; Zimmerman, R.E.; Moore, Stephen; Clouse, Melvin E.; Wu, Jing; Lin, Tin‐Kwang; Baldwin, R.M.

doi:10.1097/00004728-198210000-00041

Cited by 71 publications

(21 citation statements)

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“…Recently, functional brain imaging with single-pho ton emission computed tomography (SPECT) (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12). positron emission computed tomography (PET) ( 13,14) and m Xc inhalation (15) have come to be used for the localization of epileptic foci in patients with epilepsy.…”

Section: Introductionmentioning

confidence: 99%

Imaging of Propagated Sites of Epileptic Discharges in Repeated <sup>123</sup>I-IMP SPECT Scans

1990

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Single-photon emission computed tomographic (SPECT) brain scans with N-isopropyl-(iodine-123-p-iodoamphetamine (¹²³I-IMP) were performed twice at an interval of about 2.5 years in the interictal period in an adult patient with occipital-lobe epilepsy. The first SPECT scan showed an abnormal image of decreased ¹²³I-IMP uptake in the right occipital lobe. This abnormal image was regarded as the primary focus of his epilepsy on the basis of its regional agreement with right-occipital spikes consistently seen in interictal electroencephalographic recordings throughout his clinical history. In the second scan, he showed multiple abnormal images of decreased uptake in the right frontotemporal lobes and left occipital lobe together with the right occipital lobe. These additional abnormal images were considered to be propagated sites of epileptic discharges.

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Section: Introductionmentioning

confidence: 99%

Imaging of Propagated Sites of Epileptic Discharges in Repeated <sup>123</sup>I-IMP SPECT Scans

1990

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“…(198 1). Recently, stati cally distributed radiopharmaceuticals have been developed that can also be used in combination with SPECT systems to estimate rCBF (Winchell et aI., 1980;Hill et aI., 1982;Kuhl et aI., 1982;Devous et aI., 1983;Kung et aI., 1983). Separately, stable xenon-enhanced x-ray computed tomography (CT), as described by Drayer et al (1978), has been used to obtain both rCBF and regional xenon partition coefficients in humans.…”

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confidence: 99%

Normal Distribution of Regional Cerebral Blood Flow Measured by Dynamic Single-Photon Emission Tomography

Devous

Stokely

Chehabi

et al. 1986

J Cereb Blood Flow Metab

161

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Summary: Regional CBF (rCBF) was measured quanti tatively using the inert-gas washout technique with xenon-133 and single-photon emission computed tomog raphy. Tomographic data were reconstructed by filtered back projection, and flow was calculated according to the double-integral method, Ninety-seven subjects ranging in age from 20 to 59 years received a single examination; eight of these received a second examination within 1 h of the first; seven others received a second examination separated from the first by 1-10 days. Transverse-section images were obtained at 2, 6, and 10 cm above and par allel to the canthomeatal line (CML). Cortical gray matter flows were obtained from 12 brain regions in the slice 6The measurement of regional CBF (rCBF) in hu mans began with the pioneering work of Kety and Schmidt (1945) in which they employed the nitrous oxide method to measure mean hemispheric blood flow. A decade later, Lassen and lngvar (196 1) adapted this technique to the external detection of radioactive inert-gas tracers, namely 85Kr. By using multiple detectors, multiple brain regions could be examined for abnormalities in rCBF. Advances in tracer technology led to the widespread use of 1 33 Xe in place of 8 5Kr, while advances in detectors, col limation, and data analysis led to ever increasing number of probes (up to 254) and thus regions of brain subjected to rCBF analysis (Veall and Mallett, 1966; Obrist et aI., 1975; Risberg et aI., 1975; lngvar, 1976; Sveinsdottir et aI., 1977; Lassen et aI. , 1978). where there was no difference. Flow was higher in women than in men and declined mildly with age for both sexes (slope = -0.33 mllmin/lOO g/year; p < 0.05).

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“…2 " 7 The second was the introduction of a high-sensitivity SPECT system. 89 Because its sensitivity is so much higher than that of rotating cameras, acquisitions take only a few minutes and can be repeated easily.…”

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confidence: 99%

Pathophysiologic study of chronic infarcts with I-123 isopropyl iodo-amphetamine (IMP): the importance of periinfarct area.

Raynaud¹,

Rancurel²,

Samson³

et al. 1987

Stroke

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Seventeen chronic cerebral Infarcts were investigated by a highly sensitive, dedicated brain single photon emission computerized tomography system using li3 I-isopropyl iodoamphetamine (IMP) and LU Xe. IMP uptake was measured 10 minutes, 2 hours, and 5 hours after injection, and regional cerebral blood flow was measured with 133 Xe. In 4 cases a positron emission tomography system was used to measure the rCBF and the regional metabolic rate of oxygen with C 15 O 2 and '*O 2 -The results obtained allowed us to identify 2 abnormal zones. One, the "central area," was characterized by a severe decrease in IMP uptake and rCBF averaging 34% and 46% respectively and by a hypodense image on the x-ray computerized tomography scan. The second, the periinfarct or "peripheral area" was characterized by a moderate decrease in IMP uptake and regional cerebral blood flow averaging 13 and 19% respectively; this area extended around the central area and had a normal density on computerized tomography scan. The IMP hypofixation of the peripheral area observed at the 10th minute tended to disappear at the 5th hour. The volume of this area was often found to be quite large, covering more than 30% of a hemisphere whereas the central area did not exceed 25%. C EREBRAL single photon emission tomography (SPECT) has benefited from two major improvements in recent years. The first was the advent of I-123-isopropyl-iodoamphetamine (IMP), which can be considered the first real brain agent 1 placed at the disposition of every nuclear medicine center. Its usefulness is recognized in cerebrovascular patients in obtaining both the localization and the extent of infarcts whether such infarcts are visible or not by x-ray computerized tomography (CT).2 " 7 The second was the introduction of a high-sensitivity SPECT system. 89 Because its sensitivity is so much higher than that of rotating cameras, acquisitions take only a few minutes and can be repeated easily. With this system, regional cerebral blood flow (rCBF) measured with 133 Xe and IMP values can be obtained on the same areas of the tomographic slices.Using this high-sensitivity SPECT system we studied 17 patients with chronic infarcts; a few were also studied with a positron emission tomography (PET) system. The results obtained emphasize the pathophysiological importance of the periinfarct area in Received October 18, 1985; accepted July 29, 1986. which IMP uptake, CBF, and metabolic activity are decreased. Subjects and MethodsTwo SPECT systems were used. All patients were studied with the Tomomatic 64, a hybrid bar-camera array system; a few were also studied using a rotating camera (GE-400 A) connected to a SIMIS 4 computer. Physical characteristics of both systems have been described in detail elsewhere.8 "" We will only detail here the "relative ' sensitivity of the Tomomatic, which we found to be 20-25 times higher than that of the GE-400 A for 123 I allowing for shorter acquisition times. With both systems "relative" sensitivity represents the count number of a 2-cm-thick...

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Initial Experience With Spect (Single-Photon Computerized Tomography) Ok the Brain Using N-Isopropyl 1–123 P-Iodoamphetamine

Cited by 71 publications

References 0 publications

Imaging of Propagated Sites of Epileptic Discharges in Repeated <sup>123</sup>I-IMP SPECT Scans

Imaging of Propagated Sites of Epileptic Discharges in Repeated <sup>123</sup>I-IMP SPECT Scans

Normal Distribution of Regional Cerebral Blood Flow Measured by Dynamic Single-Photon Emission Tomography

Pathophysiologic study of chronic infarcts with I-123 isopropyl iodo-amphetamine (IMP): the importance of periinfarct area.

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