Initial hazard assessment of benzyl salicylate: In vitro genotoxicity test and combined repeated-dose and reproductive/developmental toxicity screening test in rats

Igarashi, Takako; Takashima, Hiromasa; Takabe, Michihito; Suzuki, Hiroshi; Ushida, Kaori; Kawamura, Tomoko; Matsumoto, Mariko; Iso, Takako; Tanabe, Shihori; Inoue, Kaoru; Ono, Atsushi; Yamada, Takashi; Hirose, Akihiko

doi:10.1016/j.yrtph.2018.10.018

Cited by 9 publications

(4 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For instance, 100% of the Fresno participants who wore wristbands were exposed to several chemicals used in fragrances, including ethylene brassylate, benzyl salicylate, tonalide, betaionone, and lilial (Supplementary Table 3). While there is evidence of developmental toxicity for one of these chemicals, benzyl salicylate [34], the others have no or limited evidence insufficient to characterize their to affect human development [35][36][37]. Two phthalates used as plasticizers, diisobutyl phthalate (DIBP) and din-butyl phthalate (DBP), were also detected in 100% of the women wearing wristbands, both of which are known reproductive and developmental toxicants [38][39][40][41].…”

Section: Discussionmentioning

confidence: 99%

Investigating geographic differences in environmental chemical exposures in maternal and cord sera using non-targeted screening and silicone wristbands in California

Goin

Abrahamsson

Wang

et al. 2022

J Expo Sci Environ Epidemiol

View full text Add to dashboard Cite

Background Differential risks for adverse pregnancy outcomes may be influenced by prenatal chemical exposures, but current exposure methods may not fully capture data to identify harms and differences. Methods We collected maternal and cord sera from pregnant people in Fresno and San Francisco, and screened for over 2420 chemicals using LC-QTOF/MS. We matched San Francisco participants to Fresno participants (N = 150) and compared detection frequencies. Twenty-six Fresno participants wore silicone wristbands evaluated for over 1500 chemicals using quantitative chemical analysis. We assessed whether living in tracts with higher levels of pollution according to CalEnviroScreen correlated with higher numbers of chemicals detected in sera. Results We detected 2167 suspect chemical features across maternal and cord sera. The number of suspect chemical features was not different by city, but a higher number of suspect chemicals in cosmetics or fragrances was detected in the Fresno versus San Francisco participants’ sera. We also found high levels of chemicals used in fragrances measured in the silicone wristbands. Fresno participants living in tracts with higher pesticide scores had higher numbers of suspect pesticides in their sera. Conclusions Multiple exposure-assessment approaches can identify exposure to many chemicals during pregnancy that have not been well-studied for health effects.

show abstract

Section: Discussionmentioning

confidence: 99%

Investigating geographic differences in environmental chemical exposures in maternal and cord sera using non-targeted screening and silicone wristbands in California

Goin

Abrahamsson

Wang

et al. 2022

J Expo Sci Environ Epidemiol

View full text Add to dashboard Cite

show abstract

“…We report the results of an OECD TG 422 study and hazard assessment of polyoxymethylene. Our earlier work on hazard assessment of other substances is also available in scientific journals (Kawashima et al, 2020;Matsumoto et al, 2021;Igarashi et al, 2020Igarashi et al, , 2018aIgarashi et al, , 2018b. Study reports are accessible via the Japan Existing Chemical Database (JECDB, 2021).…”

Section: Discussionmentioning

confidence: 99%

Repeated-dose and reproductive/developmental toxicity screening of polyoxymethylene in rats

Matsumoto¹,

Fujii

Hirose³

et al. 2021

Fundam. Toxicol. Sci.

Self Cite

View full text Add to dashboard Cite

The Japanese government requires risk assessment of chemicals under the Chemical Substances Control Law (CSCL). Toxicity data for polyoxymethylene (paraformaldehyde; CAS No.: 30525-89-4) for human health are insufficient though the chemical needs a screening assessment under the CSCL. Thus, polyoxymethylene was selected by the Safety Examination of Existing Chemicals and Safety Programmes of the Ministry of Health, Labour and Welfare (MHLW) to assess repeated-dose and reproductive/developmental toxicity. A combined toxicity screening was conducted following the OECD TG422. Male and female rats were administered the test chemical once daily by gavage at doses of 0 (control), 20, 60, or 200 mg/kg bw from 14 days before mating for a total of 28 to 61 days. The 200 mg/ kg bw/day dose caused a significant decrease in food consumption. Histopathological examination found ulcers in the forestomach and glandular stomach, and erosion and inflammatory cell infiltration in the submucosa of the glandular stomach at the end of dosing in both sexes. Inflammatory cell infiltration in the submucosa of the glandular stomach was also observed in both sexes after the recovery period. No reproductive and developmental toxicity was observed even at the highest dose. A no-observed-adverse-effect level (NOAEL) for repeated-dose toxicity was 60 mg/kg bw/day, and a NOAEL for reproductive and developmental toxicity was 200 mg/kg bw/day, the highest dose tested.

show abstract

“…The screening assessment for the CSCL includes calculation of a D-value for hazard classification (Igarashi et al, 2018). The D-value corresponds to the Derived No Effects Levels of the European Regulation on REACH and is similar to the Tolerable Daily Intake.…”

Section: Discussionmentioning

confidence: 99%

Combined repeated-dose and reproductive/developmental oral toxicity of 3-methylpentane, isooctane, and isononane in rats

Kawashima¹,

Inoue²,

Yoshizaki³

et al. 2020

Fundam. Toxicol. Sci.

Self Cite

View full text Add to dashboard Cite

3-Methylpentane, isooctane, and isononane are acyclic branched saturated hydrocarbons with carbon numbers C6, C8, and C9, respectively. To assess human risk, we conducted a combined repeated-dose and reproductive/developmental oral toxicity studies in rats. [Organization for Economic Co-operation and Development (OECD) Test Guideline 422]. Each hydrocarbon was administered by gavage to rats at three doses (plus a control group). All three chemicals targeted the liver and kidney. An increase in liver weight without hepatic injury was observed as the adaptive response to the chemical treatments. Males treated by each chemical showed α2u-globulin nephropathy, which is a rat-specific finding that bears no human relevance. Reproduction/developmental toxicity parameters showed no treatment-related effects in parents or offspring at any dose for the three chemicals, except for the retardation of offspring bodyweight development which may be a secondary effect of a maternal systemic condition or direct effect on offspring in isononane. No observed adverse effect levels (NOAELs) of repeated toxicity in either sex were determined to be 300 mg/kg/day for 3-methylpentane, 100 mg/kg/day for isooctane, and 250 mg/kg/day for isononane. NOAELs of reproductive/developmental toxicity in parents and offspring were determined to be 1000 mg/kg/day for 3-methylpentane, and 300 mg/kg/day for isooctane. For isononane, NOAELs were determined to be 1000 mg/kg/day for reproduction, and 250 mg/kg/day for offspring development. These results provide new toxicological information and support the category assessment of published reports that evaluate the acyclic branched saturated hydrocarbons as low-toxicity substances.

show abstract

Initial hazard assessment of benzyl salicylate: In vitro genotoxicity test and combined repeated-dose and reproductive/developmental toxicity screening test in rats

Cited by 9 publications

References 22 publications

Investigating geographic differences in environmental chemical exposures in maternal and cord sera using non-targeted screening and silicone wristbands in California

Investigating geographic differences in environmental chemical exposures in maternal and cord sera using non-targeted screening and silicone wristbands in California

Repeated-dose and reproductive/developmental toxicity screening of polyoxymethylene in rats

Combined repeated-dose and reproductive/developmental oral toxicity of 3-methylpentane, isooctane, and isononane in rats

Contact Info

Product

Resources

About