Initial Report of an Intradural Extramedullary Metastasis of a Pancreatic Neuroendocrine Tumor to the Cervical Spine: A Case Report and Review of the Literature

Saway, Brian; Fayed, Islam; Dowlati, Ehsan; Derakhshandeh, Roshanak; Sandhu, Faheem A.

doi:10.1016/j.wneu.2020.04.120

Cited by 6 publications

(5 citation statements)

References 34 publications

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“…Spine EBRT proved to be effective in patients with metastatic spinal cord compression to reduce postsurgical residual tumor volumes and prolong local control (75). In these pooled patients, locoregional spine EBRT mainly targeted the lesions of interest, but was also extended to other spine regions in case of multiple simultaneous IESMs and/or concurrent vertebral metastases (54,55,60). Targeted adjuvant SRS (with a 10 Gy dose) was used in the recent report of Pagano et al (64) with no radiation-induced adverse events, suggesting the feasibility and safety of this protocol for the management of IESMs.…”

Section: Discussionmentioning

confidence: 99%

Intradural Extramedullary Spinal Metastases from Non-neurogenic Primary Tumors: A Systematic Review

et al. 2022

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Background/Aim: Intradural extramedullary spinal metastases (IESMs) may severely affect quality-of-life of oncological patients. Several treatments are available but their impact on prognosis is unclear. We systematically reviewed the literature on IESMs of non-neurogenic origin. Materials and Methods: PubMed, Ovid EMBASE, Scopus, and Web-of-Science were screened to include articles reporting patients with IESMs from non-neurogenic primary tumors. Clinico-radiological presentation, treatments, and outcomes were analyzed. Results: We included 51 articles encompassing 130 patients of a median age of 62 years (range=32-91 years). The most common primary neoplasms were pulmonary (26.2%), renal (20%), and breast (13.8%) carcinomas. Median time interval from primary tumor to IESMs was 18 months (range=0-240 months). The most common symptoms were sensory (58.3%) and motor (54.2%) deficits. Acute cauda equina syndrome was reported in 29 patients (37.7%). Lesions were diagnosed at magnetic resonance imaging (93.3%), myelography (25%), or computed

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Section: Discussionmentioning

confidence: 99%

Intradural Extramedullary Spinal Metastases from Non-neurogenic Primary Tumors: A Systematic Review

et al. 2022

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“…[ 4 - 6 ] The young age of our patient, 34, led to the first diagnostic suspicion of a lymphoproliferative lesion (i.e., lymphoma), but this was ruled out when the whole-body PET CT scan documented multiple bone metastatic lesions. [ 6 - 8 ]…”

Section: Discussionmentioning

confidence: 99%

“…We found only two cases of comparable metastatic neuroendocrine dumbbell tumors of unknown origin in the literature. [ 4 , 8 ] Mori et al . reported a 51-year-old female with the sudden onset of paraplegia due to a dumbbell-shaped metastatic extradural lesion at the T10 and T11 levels accompanied by multiple vertebral metastases from a rectal NET.…”

Section: Discussionmentioning

confidence: 99%

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Thoracic dumbbell spinal metastasis secondary to neuroendocrine tumor of unknown origin: Case report and literature review

Costanzo¹,

Porzio²,

Gerardi³

et al. 2022

Surgical Neurology International

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Background: Dumbbell tumors are typically benign schwannomas, neurofibromas, and meningiomas and only rarely there are malignant variants of these lesions or other malignant histotypes. Here, a 34-year-old male presented with a thoracic spinal dumbbell metastatic neuroendocrine carcinoma of unknown primary origin. Case Description: A 34-year-old male presented with 2 months of thoracic pain and progressive mid thoracic sensory loss. A post contrast thoracic MRI showed a dumbbell tumor localized between the T7 and T9 levels with extension laterally into the T7-T8 and T8-T9 foramina. The patient underwent a laminectomy for tumor resection following which his pain and gait improved. Histopathologically, the tumor demonstrated multiple rounded small cells with a Ki67 level around 30%, suggesting a malignant metastatic neuroendocrine tumor of unknown etiology. Conclusion: We successfully treated a 34-year-old male with a T7-T9 malignant spinal dumbbell neuroendocrine tumor of unknown etiology utilizing a decompressive laminectomy.

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“…Vertebral metastases are most commonly due to breast, prostate, lung, thyroid, renal cell, bladder, and melanotic cancers, with the incidence of skeletal metastases in pancreatic cancer being lower at 5-20% [ 6 , 7 ]. Cervical involvement in pancreatic cancer is even rarer, with only four cases being noted in the literature and no cases involving C2 in particular [ 8 - 11 ]. Vertebral body involvement can be asymptomatic but, when accompanied by fracture, can instead cause uncontrolled pain and instability that is refractory to conservative measures and can predispose patients to cord compression.…”

Section: Discussionmentioning

confidence: 99%

Vertebroplasty of C2 Pathologic Fracture: A Unique Case Report Using a Curved-Needle Technique

Swarnkar¹,

Zain²,

Christie³

et al. 2022

Cureus

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Minimally invasive vertebroplasty has arisen as a viable alternative treatment for pathologic vertebral body fractures. Vertebroplasty is well documented in the thoracic and lumbar spine from the posterolateral approach, but is rarely employed in the cervical spine in consideration of numerous critical neural and vascular structures that must be avoided. Careful technique and usage of imaging is necessary to maneuver crucial structures and minimize risk of complication. In the posterolateral approach, the lesion has to lie in the trajectory of a straight needle, in the lateral aspect of the C2 vertebra. This approach may limit adequate treatment of lesions that are located more medially. We describe a unique case report of successful and safe posterolateral approach treatment of a destructive medial C2 vertebra metastatic lesion using a curved needle.

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Initial Report of an Intradural Extramedullary Metastasis of a Pancreatic Neuroendocrine Tumor to the Cervical Spine: A Case Report and Review of the Literature

Cited by 6 publications

References 34 publications

Intradural Extramedullary Spinal Metastases from Non-neurogenic Primary Tumors: A Systematic Review

Intradural Extramedullary Spinal Metastases from Non-neurogenic Primary Tumors: A Systematic Review

Thoracic dumbbell spinal metastasis secondary to neuroendocrine tumor of unknown origin: Case report and literature review

Vertebroplasty of C2 Pathologic Fracture: A Unique Case Report Using a Curved-Needle Technique

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