Initial resistance of Mycobacterium tuberculosis in Northern Nigeria

Fawcett, I. W.; Watkins, B J; Davies, D.L.J.; Phillips, Ian

doi:10.1016/0041-3879(76)90020-9

Cited by 15 publications

(11 citation statements)

References 2 publications

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“…Individual isoniazid and streptomycin resistance had been reported in Nigeria in 7 and 2% of new patients with TB in the 1970s, [4] and subsequent unpublished studies using Lowenstein-Jensen media and proportion DST methods suggested that there was a rising trend in drug resistance. For example, Kolo reported in 1991 that 19, 13 and 29% of newly diagnosed patients with TB in Zaria had isoniazid, streptomycin and pyrazinamide resistance [7] and resistance to these drugs was reported to have increased to 29, 14 and 42% by 2006, [8] suggesting that although poorly documented, MDR-TB is likely to have been present among newly diagnosed patients in Nigeria for some time.…”

Section: Discussionmentioning

confidence: 96%

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Pilot study on multidrug resistant tuberculosis in Nigeria

Lawson

Habib²,

Okobi

et al. 2010

Ann Afr Med

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Section: Discussionmentioning

confidence: 96%

“…[1][2][3] In Nigeria, about 21% of all TB patients are dually infected with TB and HIV. [1][2][3] In vitro resistance to anti-TB drugs was first reported in Nigeria over three decades ago [4] and local health practitioners have the perception that drug resistance has increased in the recent years.…”

Section: Introductionmentioning

confidence: 99%

Pilot study on multidrug resistant tuberculosis in Nigeria

Lawson

Habib²,

Okobi

et al. 2010

Ann Afr Med

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“…In Africa, the contribution of NTM to such disease has been examined on a small scale only [1]. Two previous studies in Nigeria show that Fawcett and Watkins [12] did not isolate mycobacteria other than those causing tuberculosis in their study in the northern region of the country. However, 11% atypical Mycobacteria have been reported in Lagos in 1986 [6].…”

Section: Discussionmentioning

confidence: 99%

Acid-Fast Bacilli Other than Mycobacteria in Tuberculosis Patients Receiving Directly Observed Therapy Short Course in Cross River State, Nigeria

Pokam

Asuquo

2012

Tuberculosis Research and Treatment

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The information on the contribution of non tuberculous mycobacteria (NTM) to mycobacterial infections in Africa is scarce due to limited laboratory culture for its isolation and identification. One hundred and thirty-seven sputum smear positive patients were recruited into a study on the molecular epidemiology of Mycobacterium tuberculosis in Cross River State. Following sputum culture, 97 pure isolates were obtained and identified using Capilia TB-Neo and further confirmed by the GenoType Mycobacterium CM kit. Of the 97 isolates, 81 (83.5%) isolates were Capilia TB-Neo positive while 16 (16.5%) were Capilia TB-Neo negative. Further confirmation with the GenoType Mycobacterium CM kit revealed that 4 (25%) of the 16 isolates belonged to NTM and included M. fortuitum I, M. fortuitum II/M magaritense, M. abscessus, and M. avium ssp. The remaining 12 (75%) Capilia TB-Neo negative isolates were not members of the genus Mycobacterium despite their AFB appearance. Six (33.3%) of the Capilia TB-Neo negative were from HIV positive tuberculosis patients. All subjects in this study were placed on DOTS shortly after the AFB results were obtained. The implication of isolation of 16.5% nontuberculous isolates further emphasizes the need for culture of sputum specimen especially in HIV positive patients prior to administration of antituberculosis therapy.

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“…It was described as early as 1976 by Fawcett in Zaria [11]. Since then, there have been other reports on TB drug resistance in various parts of the country.…”

Section: Introductionmentioning

confidence: 99%

Drug Resistance among Pulmonary Tuberculosis Patients in Calabar, Nigeria

et al. 2013

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Background. This study aimed to determine the pattern of drug susceptibility to first-line drugs among pulmonary TB patients in two hospitals in Calabar, Nigeria. Methods. This was a descriptive cross-sectional study carried out between February 2011 and April 2012. Sputum samples from consecutive TB patients in Calabar were subjected to culture on Lowenstein-Jensen (LJ) slopes followed by drug susceptibility testing (DST). The DST was performed on LJ medium by the proportion method. Results. Forty-two of the 100 Mycobacterium tuberculosis strains were found to be resistant to at least one drug. Resistance to only one drug (monoresistance) was found in 17 patients. No strains with monoresistance to rifampicin were found. Resistance to two drugs was found in 22 patients, while one patient was resistant to both three and four drugs. MDR TB was seen in 4% (4/100). The independent variables of HIV serology and sex were not significantly associated with resistance (P > 0.05). Conclusion. There was a high prevalence of anti-TB drug resistance in Calabar.

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Initial resistance of Mycobacterium tuberculosis in Northern Nigeria

Cited by 15 publications

References 2 publications

Pilot study on multidrug resistant tuberculosis in Nigeria

Pilot study on multidrug resistant tuberculosis in Nigeria

Acid-Fast Bacilli Other than Mycobacteria in Tuberculosis Patients Receiving Directly Observed Therapy Short Course in Cross River State, Nigeria

Drug Resistance among Pulmonary Tuberculosis Patients in Calabar, Nigeria

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