Ionospheric F2 peak electron densities (NmF2) measured at ten ionosonde stations have been analyzed to investigate ionospheric day-to-day variability around the Whole Heliosphere Interval (WHI) in 2008 (Day of Year (DOY) 50 -140). The ionosonde data showed that there was significant global day-to-day variability in NmF2. This variability had 5-, 7-, 9-, 11-, 13.5-, and 16 -21-day periodicities. At middle latitudes, the ionosphere appeared to respond directly to the solar-wind and interplanetary-magnetic-field (IMF) induced geomagnetic-activity forcing, with the day-to-day variability having the same periods as those in the solar-wind/IMF and geomagnetic activity. At the geomagnetic Equator, the ionosphere had a strong 7-day periodicity, corresponding to the same periodicity in the IMF B z component. In the equatorial anomaly region, the ionosphere showed more complicated day-to-day variability, dominated by the 9-day periodicity. In addition, there were also peri- odicities of 11 days and 16 -21 days in the ionosonde data at some stations. The ionosonde data were compared with the Coupled Magnetosphere Ionosphere Thermosphere (CMIT) simulations that were driven by the observed solar-wind and IMF data during the WHI. The CMIT simulations showed similar ionospheric daily variability seen in the data. They captured the positive and negative responses of the ionosphere at middle latitudes during the first corotating interaction region (CIR) event in the WHI. The response of the model to the second CIR event, however, was relatively weak.