Initial staging examinations for head and neck squamous cell carcinoma: are they appropriate?

Andrle, J; Schartinger, Volker Hans; Schwentner, Ilona; Deibl, Martina; Sprinzl, G. M.

doi:10.1017/s0022215109005258

Cited by 8 publications

(4 citation statements)

References 21 publications

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“…Almost three-fourth of metastases from SCC of head and neck was involving lung (70-75%), followed by liver (17-38%), and bones (23-44%). [15][16][17] Cutaneous metastases from SCC of head and neck malignancies is rare accounting for less than 10% of all distant metastasis. 18 Skin metastasis can present as multiple or solitary nodule, plaque, inflammatory or granulation tissue.…”

Section: Discussionmentioning

confidence: 99%

Skin metastasis within radiation field in treated squamous cell carcinoma of larynx

Selvaraj

Gudipudi

2020

Int J Otorhinolaryngol Head Neck Surg

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<p class="abstract">Cutaneous metastasis from squamous cell carcinoma (SCC) of larynx is very uncommon. Skin mestatsis in a treated of case of SCC larynx is considered to be a sign of impending distant metastasis and dismal prognosis. There are very few case reports in literature describing such presentations, and very minimal information on treatment options available for these patients. Here, we describe two cases of locally advanced SCC larynx treated with chemoradiation upfront, who later presented with cutaneous metastasis in neck within the previous radiation field. Evaluation for distant metastasis was done and started on palliative chemotherapy. The first patient had complete resolution of cutaneous nodules post 8 cycles of weekly palliative chemotherapy. However, post 18 cycles of chemotherapy, he developed a metachronous primary in upper thoracic oesophagus and disease progressed loco-regionally too. The second patient’s general condition deteriorated after 1st cycle of palliative chemotherapy, hence was offered best supportive care. Cutaneous nodules in a treated SCC of larynx must raise the suspicion of metastasis, warranting histological examination, and whole-body imaging work-up to rule out distant metastasis. Palliative chemotherapy must be advocated in all eligible patients to delay disease progression. Best supportive care can be offered in patients not eligible for chemotherapy.</p>

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Section: Discussionmentioning

confidence: 99%

Skin metastasis within radiation field in treated squamous cell carcinoma of larynx

Selvaraj

Gudipudi

2020

Int J Otorhinolaryngol Head Neck Surg

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“…Pre karcinómy hlavy a krku je charakteristické skoré metastázovanie do regionálnych krčných LU a relatívne časté lokoregionálne recidívy. Vzdialené MTS sú u týchto pa cientov zriedkavé [3]. V súčasnosti neexistujú štandardy na screen ing vzdialených MTS u pa cientov s karcinómom horného aerodigestívneho traktu.…”

Section: Dia Gnostika M1unclassified

“…M1 sa pri karcinómoch hlavy a krku najčastejšie detegujú v pľúcach, preto sa, hlavne v predchádzajúcich rokoch, vyšetrenia zameriavali predovšetkým na hrudník (röntgenové vyšetrenie, CT), kým ostatným lokalitám sa nevenovala dostatočná pozornosť [3,5]. Podľa štúdií z ostatných 5 rokoch sa však relatívne často M1 deteguje aj v iných lokalitách, predovšetkým v skelete [2,4,10].…”

Section: Dia Gnostika M1unclassified

Incidence and Risk Factors of Distant Metastases of Head and Neck Carcinoma

Uhliarova¹,

Švec²

2019

Klin Onkol

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Východiská: Karcinómy hlavy a krku sú známe častým metastázovaním do regionálnych lymfatických uzlín krku a lokoregionálnou recidívou. Na druhej strane sa vzdialené metastázy (M1) vyskytujú zriedkavo. Materiál a metódy: Retrospektívna analýza pa cientov, ktorým bol dia gnostikovaný karcinóm horného aerodigestívneho traktu (orofarynx, hypofarynx, larynx) na Oddelení otorinolaryngológie Fakultnej nemocnice s poliklinikou F. D. Roosevelta v Banskej Bystrici v rokoch 2011-2017. Sledovali sme incidenciu, lokalizáciu, rizikové faktory, dia gnostický postup M1 a dĺžku prežívania pa cientov s diseminovaným ochorením. Výsledky: M1 sa dia gnostikovala u 50 (10,5 %) zo 474 pa cientov. M1 sa signifikantne častejšie vyskytovala u pa cientov s karcinómom orofaryngu, u pa cientov s rozsiahlejším primárnym nádorom (T3 a T4 status), uzlinovým postihnutím (N2 a N3 status) a zle diferencovaným karcinómom. M1 sa najčastejšie detegovala v pľúcach (59 %) a v skelete (47 %). Najčastejšie (84 %) sa M1 dia gnostikovala pomocou vyšetrenia počítačovou tomografiou (CT), pozitrónovou emisnou tomografiou s CT (PET/ CT) sa dia gnostikovala u 12 %. Prežívanie pa cientov po dia gnostike M1 bolo priemerne 10,4 ± 3,5 mesiaca, dvaja pa cienti sú stabilizovaní, v remisii. Záver: Najdôležitejšiu úlohu v detekcii M1 zohráva CT vyšetrenie hrudníka. Pri prítomnosti rizikových faktorov (metastázy vo viac ako troch lymfatických uzlinách, bilaterálne metastatické postihnutie lymfatických uzlín, metastáza v lymfatickej uzline väčšej ako 6 cm, lokalizácia metastáz v lymfatických uzlinách supraklavikulárne a lokoregionálna recidíva) je vhodné celotelové PET/ CT vyšetrenie. U pa cientov s dobrým performance statusom pri solitárnej M1 a lokoregionálnej remisii ochorenia je možná kuratívna liečba. Kľúčové slová karcinómy hlavy a krku-vzdialené metastázy-dia gnostika-prežívanie Summary Background: Head and neck carcinomas are characterized by frequent metastases to cervical lymph nodes and locoregional recurrence. By contrast, distant metastases (M1) are seldom detected. Material and methods: This study retrospectively analyzed patients with head and neck cancer who were treated at the Department of Otorhinolaryngology of F. D. Roosevelt Faculty Hospital in Banska Bystrica in 2011-2017. M1 incidence, localization, and risk factors were determined, as well as time to development of M1, methods of M1 diagnosis, and patient survival. Results: M1 was diagnosed in 50 (10.5%) of 474 patients and was significantly more frequent in patients with oropharyngeal cancer, more extensive primary tumors (T3 and T4 status), nodal disease (N2 and N3 status), and poorly differentiated carcinomas. M1 was most often detected in the lungs (59%) and skeleton (47%). M1 was detected by computed tomography (CT) scans in 84% of patients and by, positron emission tomography/CT (PET/CT) in 12%. Mean patient survival was 10.4 ± 3.5 months, with two patients being in remission. Conclusion: M1 is detected most frequently by CT scans. PET/CT screening is indicated in patients with risk factors,...

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“…7,31 However, given the low prevalence of distant bone metastases in only 2-4% of patients with oral cancer, whole-body imaging seems less appropriate in this regard. 8 Van Cann et al reported an accuracy of 85% with no false-negative results using CT or MRI in combination with BS for detecting bone invasion. 5 No single imaging modality is considered sufficiently accurate to replace the others.…”

mentioning

confidence: 99%

Performance of cone beam computed tomography in comparison to conventional imaging techniques for the detection of bone invasion in oral cancer

Linz¹,

Müller‐Richter²,

Buck³

et al. 2015

International Journal of Oral and Maxillofacial Surgery

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Initial staging examinations for head and neck squamous cell carcinoma: are they appropriate?

Abstract: Computed tomography of the thorax is the most important technique for screening patients with head and neck squamous cell carcinoma.

Cited by 8 publications

References 21 publications

Skin metastasis within radiation field in treated squamous cell carcinoma of larynx

Skin metastasis within radiation field in treated squamous cell carcinoma of larynx

Incidence and Risk Factors of Distant Metastases of Head and Neck Carcinoma

Performance of cone beam computed tomography in comparison to conventional imaging techniques for the detection of bone invasion in oral cancer

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