Initial Study on COMT and DRD2 Gene Polymorphisms as Well as the Influence of Temperament and Character Trait on the Severity of Alcohol Craving in Alcohol-Dependent Patients

Czarnecki, Damian; Ziółkowski, Marcin; Chodkiewicz, Jan; Długosz, Anna; Feldheim, Joanna; Waszkiewicz, Napoleon; Kułak-Bejda, Agnieszka; Gorzkiewicz, Marta; Budzyński, Jacek; Junkiert-Czarnecka, Anna; Siomek-Górecka, Agnieszka; Nicpoń, Krzysztof J; Kawala-Sterniuk, Aleksandra; Ferri, Raffaele; Pelc, Mariusz; Walecki, Piotr; Laskowska, Ewa; Gorzelańczyk, Edward Jacek

doi:10.3390/jcm10245892

Cited by 4 publications

(2 citation statements)

References 88 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Factors predisposing individuals to the development of psychiatric disorders and their markers are infectious/immune, metabolic, and environmental (e.g., stress, atmospheric, dietetical, etc.) and also (epi)genetic and neoplastic aetiology [54,55]. An example of difficulties in aetiological interpretation in psychiatric research is explaining the formation of mood disorders by only one factor, e.g., dietary changes.…”

Section: Discussionmentioning

confidence: 99%

Ordering Knowledge in the Markers of Psychiatric/Mental Disorders

Waszkiewicz

2022

JCM

Self Cite

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

Ordering Knowledge in the Markers of Psychiatric/Mental Disorders

Waszkiewicz

2022

JCM

Self Cite

View full text Add to dashboard Cite

show abstract

“…The SNP loci of catechol-O-methyl transferase(COMT:rs4680, rs165599, and rs737865) was relevant to cognitive competence [24]. The translational product of COMT gene plays a key role in clearing catecholamines (such as dopamine, epinephrine and norepinephrine) in human brain [25]. Small et al…”

Section: Introductionmentioning

confidence: 99%

The COMT Rs737865 Mediates Chemo-Brain In Breast Cancer Patients With Various Index Of Ki-67

Yao

et al. 2022

Preprint

View full text Add to dashboard Cite

Background: Anterior findings denoted that catechol-O-methyltransferase (COMT) have been considered as genetic risk for chemo-brain. However, the mediation of COMT polymorphism for chemo-brain in breast cancer patients with various index of ki-67 was still unknown.Objective: The current research intended to assess the genetic risk by COMT genotype for chemo-brain in breast cancer patients with various index of ki-67.Methods: Breast cancer patients (65 with ki-67<14%, 75 with ki-67>14%) fulfilled cognitive tests pre and post adjuvant chemotherapy, three single-nucleotide polymorphisms (SNPs) of COMT (rs165599, rs4680, rs737865) were genotyped by furnishing peripheral blood.Results: The lower cognitive of breast cancer patients were displayed in compared with those before chemotherapy. Further, the event-based prospective memory (EBPM) scores of ki-67>14% group patients were worse than those of ki-67<14% group patients after chemotherapy (z=-7.51, p<0.01), but the time-based prospective memory (TBPM) scores of two groups were no significant difference. The COMT rs737865 A/G genotype was associated with memory protective susceptibility (co-dominant model: adjusted, OR=0.135, CI95%=0.026-0.706, p =0.018), A/G genotype carriers exhibited more well on EBPM test relative to A/A genotype. Conclusion: The index of ki-67 was likely to be associated with EBPM decline in breast cancer patients. Moreover, the COMT rs737865 polymorphism was potential genetic risk of chemo-brain in breast cancer patients with various index of ki-67.

show abstract

Confusion of Alcohol Craving With Food Hunger in Alcohol-Dependent Individuals Entering In-Patient Drug Treatment

Czarnecki

Ziółkowski

Chodkiewicz

et al. 2023

Alcohol and Alcoholism

View full text Add to dashboard Cite

Aim To identify the distinguishing characteristics of alcohol dependent patients who confuse alcohol cravings with pre-meal hunger. Methods Data were collected at interview on sociodemographic status, clinical status and anthropometry in 179 patients (163 men and 16 women) undergoing in-patient treatment for alcohol dependence. Results A comparison of the patient subgroups studied showed that patients who did not confuse, and those who did confuse, alcohol craving with pre-meal hunger differed significantly in terms of alcohol craving scale scores (9 vs. 4 points). Patients confusing alcohol cravings with pre-meal hunger were more likely to recognize that experiencing severe pre-meal hunger can cause relapse (67.9 vs. 22.8%) and that not being able to distinguish between the sensations under study also increases the risk of breaking abstinence (75.0% vs. 50.4%). This was independent of severity of dependence and intensity of recent alcohol consumption. Conclusions Alcohol-dependent persons who confuse alcohol craving with pre-meal hunger differ from those who do not confuse these hunger pangs in terms of feeling stronger alcohol craving and more frequent occurrence of symptoms accompanying the feeling of alcohol craving during pre-meal hunger. At the start of treatment for alcohol withdrawal, alcohol-dependent individuals who report confusing alcohol cravings with pre-meal hunger are less confident of maintaining abstinence. This is relevant to treatment. The role of possible confounders (depressive symptoms, cognitive and educational deficiency) could not be elucidated definitively.

show abstract

Initial Study on COMT and DRD2 Gene Polymorphisms as Well as the Influence of Temperament and Character Trait on the Severity of Alcohol Craving in Alcohol-Dependent Patients

Cited by 4 publications

References 88 publications

Ordering Knowledge in the Markers of Psychiatric/Mental Disorders

Ordering Knowledge in the Markers of Psychiatric/Mental Disorders

The COMT Rs737865 Mediates Chemo-Brain In Breast Cancer Patients With Various Index Of Ki-67

Confusion of Alcohol Craving With Food Hunger in Alcohol-Dependent Individuals Entering In-Patient Drug Treatment

Contact Info

Product

Resources

About