Initiated CVD of Poly(2‐Hydroxyethyl Methacrylate) Hydrogels: Synthesis, Characterization and In‐vitro Biocompatibility

Abstract

Initiated (i)CVD, an all-dry, one-step surface polymerization technique, was used to synthesize thin film hydrogels of poly (2-hydroxyethyl methacrylate) (PHEMA). Fourier transform infrared (FTIR) and nuclear magnetic resonance (NMR) spectroscopies showed stoichiometric PHEMA films obtained by iCVD. Differential scanning calorimetry (DSC) revealed a high glass transition temperature, indicative of high molecular mass polymer. In-vitro cell studies using adult human dermal fibroblasts (HDF) demonstrated the nontoxic nature and good cell adhesion properties of iCVD PHEMA films.

Effects of interfacial layer wettability and thickness on the coating morphology and sirolimus release for drug-eluting stent

“…Figure 2 shows the FTIR spectra of control Co-Cr (a), CC- and c). These vibrations and assignments are in agreements with those given in literatures [29,30]. The broad absorption peak at ~3400 clearly indicates the retention of the hydroxyl groups.…”

Photoinitiated chemical vapor deposition of cytocompatible poly(2‐hydroxyethyl methacrylate) films

“…Whereas the homopolymer piCVD pHEMA is largely linear (as compared to the PECVD PHEMA), potentially enabling lower molecular‐weight species to leach out of the pHEMA matrix over extended time in a liquid environment, the branching and random bonding introduced by PECVD hinders such mass loss, while still allowing the film to swell. Previous literature on iCVD PHEMA films show minimal monomer or oligomeric entrainment postdeposition; however, as piCVD uses a different mechanism and different temperature profile, such entrainment may have occurred in these experiments . Previously, swelling behaviors of iCVD and piCVD pHEMA were analyzed and determined to be significant for homopolymer (55 and 40% thickness increase on swelling, respectively) and iCVD pHEMA with ∼14% crosslinking (∼15% thickness increase on swelling).…”

In Situ Synthesis and Integration of Polymer Electrolytes in Nanostructured Electrodes for Photovoltaic Applications

“…Previous FTIR and NMR studies have shown PHEMA made by iCVD to be spectroscopically identical to bulk PHEMA synthesized in the liquid phase [17,18]. In our work here, FTIR shows that iCVD allows thermal decomposition of the radical initiator without harming the monomer and as a result iCVD leads to clean polymer formation that retains the chemistry of the starting monomer, including the ester and hydroxyl groups, see Figure 1.…”

“…In our work here, FTIR shows that iCVD allows thermal decomposition of the radical initiator without harming the monomer and as a result iCVD leads to clean polymer formation that retains the chemistry of the starting monomer, including the ester and hydroxyl groups, see Figure 1. In addition, by GPC, the molecular weight of PHEMA was measured to be around 2300 g/mol, and, by DSC, PHEMA was found to be a glassy polymer with a glass transition temperature between 70-90 C, depending on molecular weight [17]. PHEMA was chosen as a potential polymer electrolyte to replace the liquid electrolyte in DSSCs as its chemical functionality is expected to facilitate ion transport of the redox couple and methacrylate polymers are known to form stable gel systems with carbonate dielectrics.…”

“…As reported in detail elsewhere [17,18], iCVD was utilized to directly form poly(2-hydroxyethyl methacrylate) (PHEMA) inside the mesoporous TiO 2 network of the DSSC photoanode. The monomer, 2-hydroxyethyl methacrylate (HEMA, Aldrich), and a free radical initiator, di-tert-amyl peroxide (TAPO, Aldrich), were metered into an iCVD reactor as vapors using precision needle valves (0.2-0.8 sccm).…”